PCB4233 EXAM 2 QUESTIONS WITH VERIFIED
ACCURATE ANSWERS
False - Answers - Diacylglycerol (DAG) is one of two products generated when PLC-γ
cleaves the membrane phospholipid, PIP2. This small lipid mediator remains associated
with the plasma membrane and induce calcium entry into the cell
Overexpression of GEFs - Answers - Which of the following alterations would result in
increased signaling activity of Ras?
NFAT - Answers - When T cells express defective ER calcium sensor protein, they
secrete very little IL-2 because activation of one of the following transcription is
compromised. That transcription factor is:
LFA-1 conversion to a high affinity binding state - Answers - Integrin- dependent T cell
adhesion to antigen presenting cells increases substantially following TCR stimulation.
This increased integrin- dependent adhesion is mediated in part by:
True - Answers - Like TCR signaling, B cel receptor (BCR) signaling is initiated by
kinase phosphorylating tyrosine resides in ITAM motids of BCR signaling subunit
The phosphoinositide, (PIP3) - Answers - Lymphocyte activation leads to robust
proliferation and effector cell differentiation. The metabolic demands of these processes
are met, in part, by up-regulation of glycolytic enzymes and nutrient transporters on the
activated cell membrane. A key intermediate in the signaling pathway leading to
enhanced glucose metabolism following antigen receptor stimulation is:
CD28 - Answers - What is the receptor on T cell surface that binds to B7 family
molecules on a professional antigen-presenting cell?
Which of the following statements is the best example of a primary lymphoid organ? -
Answers - Thymus
Pre-B cell - Answers - V-J recombination occurs during which phase of a B-cell's
development?
False - Answers - During B-cell development, pre-B receptors receive signals from self-
antigens for the lymphocytes to survive and proliferate
False - Answers - In negative selection, B-cells that interact weakly with self-antigens
will either go anergic or enter a state of immunological ignorance. In both cases, the B
cells are unresponsive to the antigens, so anergy and immunological ignorance are to
names for the same phenomena
ACCURATE ANSWERS
False - Answers - Diacylglycerol (DAG) is one of two products generated when PLC-γ
cleaves the membrane phospholipid, PIP2. This small lipid mediator remains associated
with the plasma membrane and induce calcium entry into the cell
Overexpression of GEFs - Answers - Which of the following alterations would result in
increased signaling activity of Ras?
NFAT - Answers - When T cells express defective ER calcium sensor protein, they
secrete very little IL-2 because activation of one of the following transcription is
compromised. That transcription factor is:
LFA-1 conversion to a high affinity binding state - Answers - Integrin- dependent T cell
adhesion to antigen presenting cells increases substantially following TCR stimulation.
This increased integrin- dependent adhesion is mediated in part by:
True - Answers - Like TCR signaling, B cel receptor (BCR) signaling is initiated by
kinase phosphorylating tyrosine resides in ITAM motids of BCR signaling subunit
The phosphoinositide, (PIP3) - Answers - Lymphocyte activation leads to robust
proliferation and effector cell differentiation. The metabolic demands of these processes
are met, in part, by up-regulation of glycolytic enzymes and nutrient transporters on the
activated cell membrane. A key intermediate in the signaling pathway leading to
enhanced glucose metabolism following antigen receptor stimulation is:
CD28 - Answers - What is the receptor on T cell surface that binds to B7 family
molecules on a professional antigen-presenting cell?
Which of the following statements is the best example of a primary lymphoid organ? -
Answers - Thymus
Pre-B cell - Answers - V-J recombination occurs during which phase of a B-cell's
development?
False - Answers - During B-cell development, pre-B receptors receive signals from self-
antigens for the lymphocytes to survive and proliferate
False - Answers - In negative selection, B-cells that interact weakly with self-antigens
will either go anergic or enter a state of immunological ignorance. In both cases, the B
cells are unresponsive to the antigens, so anergy and immunological ignorance are to
names for the same phenomena
