Advanced Pharmacology Across the Lifespan Exam 1
Study online at https://quizlet.com/_7y49f2
1. Four phases of pharmacokinetics: absorption, distribution, metabolism, excretion
2. Pharmicokinetics: The study of the effect the body has on a medication
3. Age • Pregnancy • Hepatic or renal disease • Drug interaction: medications,
food, herbal supplements • Ethnicity • Metabolism • GI surgeries • Nutrition
status: Pharmicokinetic factors
4. Bioavailability: The fraction or percentage of a drug that reaches the systemic circulation
5. Allosteric site: A binding site for substrates not active in initiating a response; a substrate the binds to an
allosteric site may induce a conformational change in the structure of the active site, rendering it more or less susceptible
to response from a substrate.
6. Affinity: The attraction between a drug and a receptor
7. First pass effect: the phenomenon by which a drug first passes through the liver for degradation before
distribution to the tissues
8. Ligand: Any chemical, endogenous or exogenous, that interacts with a receptor
9. Pharmacodynamics: Processes through which drugs affect the body
10. Pharcokinetics: Processes through whtich the body affects drugs
11. Prodrug: A drug that is transformed from an inactive parent drug into an active metabolite; in effect, a precursor
to the active drug
12. Second messenger: A chemical produced intracellularly in response to a receptor signal; this second
messenger initiates a change in the intracellular response.
13. Upregulation: Increased availability of receptors
14. Downregulation: Decreased availability of drug receptors
15. Half-life: The time required for half of a total drug amount to be eliminated from the body
16. Post-marketing research: What is another name for Phase IV clinical trials in the United States?
17. Albumin: Pharmacodynamics involves the biological effects of a drug that is exerted on a living system. This
occurs by ligand complexes with all of the following except a. Membrane receptors
b. Enzymes
c. Albumin
d. Intracelluar receptors
18. Metoprolol. Beta blocker. It blocks.: Which is an example of a drug that has affinity for a receptor
but does not elicit a response?
19. Anaphylaxis: Type I reaction, called immediate hypersensitivity reaction
1/4
Study online at https://quizlet.com/_7y49f2
1. Four phases of pharmacokinetics: absorption, distribution, metabolism, excretion
2. Pharmicokinetics: The study of the effect the body has on a medication
3. Age • Pregnancy • Hepatic or renal disease • Drug interaction: medications,
food, herbal supplements • Ethnicity • Metabolism • GI surgeries • Nutrition
status: Pharmicokinetic factors
4. Bioavailability: The fraction or percentage of a drug that reaches the systemic circulation
5. Allosteric site: A binding site for substrates not active in initiating a response; a substrate the binds to an
allosteric site may induce a conformational change in the structure of the active site, rendering it more or less susceptible
to response from a substrate.
6. Affinity: The attraction between a drug and a receptor
7. First pass effect: the phenomenon by which a drug first passes through the liver for degradation before
distribution to the tissues
8. Ligand: Any chemical, endogenous or exogenous, that interacts with a receptor
9. Pharmacodynamics: Processes through which drugs affect the body
10. Pharcokinetics: Processes through whtich the body affects drugs
11. Prodrug: A drug that is transformed from an inactive parent drug into an active metabolite; in effect, a precursor
to the active drug
12. Second messenger: A chemical produced intracellularly in response to a receptor signal; this second
messenger initiates a change in the intracellular response.
13. Upregulation: Increased availability of receptors
14. Downregulation: Decreased availability of drug receptors
15. Half-life: The time required for half of a total drug amount to be eliminated from the body
16. Post-marketing research: What is another name for Phase IV clinical trials in the United States?
17. Albumin: Pharmacodynamics involves the biological effects of a drug that is exerted on a living system. This
occurs by ligand complexes with all of the following except a. Membrane receptors
b. Enzymes
c. Albumin
d. Intracelluar receptors
18. Metoprolol. Beta blocker. It blocks.: Which is an example of a drug that has affinity for a receptor
but does not elicit a response?
19. Anaphylaxis: Type I reaction, called immediate hypersensitivity reaction
1/4
