Quiz 1: NURS 5461 / NURS5461
(Latest Update ) Adult
Gerontology Management Across the
Continuum of Care | Questions &
Answers | Grade A | 100% Correct -
UTA
Question:
Distribution• With age,
Answer:
Increased body fat and decreased lean body mass• Alters distribution so that
fat-soluble drugs are distributed more widely and water-soluble drugs less
widely• Increased distribution of fat-soluble drugs can prolong elimination
and increase duration of action• Hypnotics; analgesics
Question:
How does aging affect the volume of distribution for water-soluble drugs?
Answer:
The volume of distribution for water-soluble drugs is less in the elderly.
,Question:
What is the effect of aging on the dose required to reach a plasma target level?
Answer:
The dose required to reach a plasma target level is less in the elderly.
Question:
How does aging affect the loading dose of antibiotics?
Answer:
The loading dose of antibiotics is less in the elderly.
Question:
What is the impact of aging on albumin levels?
Answer:
Albumin levels are lower in the elderly, especially during illness.
Question:
What is the consequence of lower albumin levels in elderly patients during
illness?
Answer:
Lower albumin levels result in higher levels of free (unbound) acidic drugs,
increasing potential toxicity.
,Question:
Which drugs are mentioned as potentially toxic due to aging-related changes?
Answer:
Digoxin, Coumadin, and Dilantin.
Question:
What is Phase I Metabolism?
Answer:
It involves the oxidation and reduction of drugs, primarily catalyzed through
the cytochrome P450 system.
Question:
Where does Phase I Metabolism primarily occur?
Answer:
In the endoplasmic reticulum of hepatocytes.
Question:
How does age affect Phase I Metabolism?
Answer:
Phase I Metabolism decreases with age.
, Question:
What is a consequence of drugs undergoing Phase I Metabolism?
Answer:
Drugs metabolized this way have longer half-lives.
Question:
Name a drug that undergoes Phase I Metabolism.
Answer:
Tylenol.
Question:
Name a class of drugs that undergo Phase I Metabolism.
Answer:
Tricyclic antidepressants (TCAs).
Question:
Name a sedative that undergoes Phase I Metabolism.
Answer:
Valium.
(Latest Update ) Adult
Gerontology Management Across the
Continuum of Care | Questions &
Answers | Grade A | 100% Correct -
UTA
Question:
Distribution• With age,
Answer:
Increased body fat and decreased lean body mass• Alters distribution so that
fat-soluble drugs are distributed more widely and water-soluble drugs less
widely• Increased distribution of fat-soluble drugs can prolong elimination
and increase duration of action• Hypnotics; analgesics
Question:
How does aging affect the volume of distribution for water-soluble drugs?
Answer:
The volume of distribution for water-soluble drugs is less in the elderly.
,Question:
What is the effect of aging on the dose required to reach a plasma target level?
Answer:
The dose required to reach a plasma target level is less in the elderly.
Question:
How does aging affect the loading dose of antibiotics?
Answer:
The loading dose of antibiotics is less in the elderly.
Question:
What is the impact of aging on albumin levels?
Answer:
Albumin levels are lower in the elderly, especially during illness.
Question:
What is the consequence of lower albumin levels in elderly patients during
illness?
Answer:
Lower albumin levels result in higher levels of free (unbound) acidic drugs,
increasing potential toxicity.
,Question:
Which drugs are mentioned as potentially toxic due to aging-related changes?
Answer:
Digoxin, Coumadin, and Dilantin.
Question:
What is Phase I Metabolism?
Answer:
It involves the oxidation and reduction of drugs, primarily catalyzed through
the cytochrome P450 system.
Question:
Where does Phase I Metabolism primarily occur?
Answer:
In the endoplasmic reticulum of hepatocytes.
Question:
How does age affect Phase I Metabolism?
Answer:
Phase I Metabolism decreases with age.
, Question:
What is a consequence of drugs undergoing Phase I Metabolism?
Answer:
Drugs metabolized this way have longer half-lives.
Question:
Name a drug that undergoes Phase I Metabolism.
Answer:
Tylenol.
Question:
Name a class of drugs that undergo Phase I Metabolism.
Answer:
Tricyclic antidepressants (TCAs).
Question:
Name a sedative that undergoes Phase I Metabolism.
Answer:
Valium.
