PATHOPHYSIOLOGY OF
CHRONIC DISEASES
Mechanisms, Clinical
Mechanisms, Markers, and
Clinical Markers, and Long-Term
Long-Term Impacts
Impacts of
of
Hypertension and
Hypertension and Diabetes
Diabetes
,
1. Introduction
1. Introduction to Pathophysiology
to Pathophysiology
athophysiology is the study of the disordered
P
physiological processes associated with disease or
injury. Unlike pharmacology, which focuses on the
treatment, pathophysiology focuses on the
mechanisms by which diseases like Hypertension
and Diabetes disrupt the body's homeostatic
balance. Understanding these mechanisms is
essential for clinical diagnosis and effective patient
management.
2
2.. Hypertension:
Hypertension: The
The "Silent
"Silent Killer"
Killer"
ypertension (High Blood Pressure) occurs when the
H
force of the blood against the artery walls is too high. It
is a progressive disease that impacts the entire
circulatory system.
A.. The
A The Mechanics
Mechanics of
of Blood
Blood Pressure
Pressure
Blood pressure is determined by the equation: