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Black eschar on face of patient with diabetic ketoacidosis
Mucor or Rhizopus fungal infection
Travels through cribiform plate
vessels
Blue sclera
Osteogenesis Imperfecta (Type I collagen defect forming
triple helix) Blue due to exposure of choroidal veins
,Bluish line on gingiva and basophilic stippling
Burton line (lead poisoning)
Basophilic stippling (rRNA
remnants) Constipation, anemia,
CNS impairment
Bone pain, bone enlargement (hat size or hearing loss), arthritis
Paget disease of bone (Increased osteoclastic, then osteoblastic activity)
Osteosarcoma or heart failure
,Bounding pulses, wide pulse pressure, diastolic heart murmur, head bobbing
Aortic Regurgitation
"Butterfly" facial rash or discoid rash and Raynaud phenomenon in a young
female
Systemic lupus erythematosus
Type III Hypersensitivity (antigen-antibody complexes deposit) with
glomerulonephritis Type II hypersensitivity with autoimmune hemolysis
Carcinoma spread
Lymphatics to lymph nodes (except HCC, Renal cell, follicular thyroid and
choriocarcinoma which spread hematogenously)
Sarcoma spread
Hematogenously
Cafe-au-lait spots, Lisch nodules (iris hemartoma), cutaneous neurofibromas
Neurofibromatosis Type I, pheochromocytoma, optic gliomas
, Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious puberty,
multiple endocrine abnormalities
McCune-Albright syndrome (mosaicism, G-protein signaling mutation)
Calf pseudohypertrophy
Muscular dystrophy (Duchenne, due to X-linked frameshift > truncated
dystrophin) Dilated cardiomyopathy
High CK