GCU 631 Final exam Advanced
pathophysiology Full Comprehensive
Questions with Verified Ans
why does cancer come back - ANSWERsmall areas of metastases can lie
dormant only to explode in growth later
Complete remission of leukemia is when less then 5% blasts in marrow and
normal CBC values
malignant neoplasm of epithelial origin are known as - ANSWERcarcinomas
Burkitt lymphoma is most closely associated with - ANSWEREpstein-Barr virus
major cause of death from leukemic disease - ANSWERinfection
myeloma - ANSWERbence jones proteins in the urine
Renal insufficiency is common
elevated Ca levels, bone fractures common
,CML chronic lymphoid leukemia - ANSWER-bcr-abl translocation
-Philadelphia chromosome
-Fatigue, weight loss, abdominal discomfort, sweats
ALL Acute lymphoid leukemia - ANSWER-best prognosis for long term disease
free survival
-Primarily affects children
-activity restriction with thrombocytopenia
-Common complication is infection
-anemia, leukocytosis, thrombocytopenia, pain in long bones, fever, painless
enlarged cervical lymph nodes
non-Hodgkin lymphoma - ANSWERthere may be gastrointestinal tract
involvement
CLL Chronic lymphoid leukemia - ANSWER
AML Acute myeloid leukemia - ANSWER
,Hemophilia A - ANSWERtreatment includes Factory VIII replacement
Hemophilia B - ANSWERdeficiency in factor IX
Final step in clot formation - ANSWERclot retraction
cause for bleeding with normal platelet cound, increased PT and INR -
ANSWERVitamin K deficiency
clotting factor deficiency from the liver
Vitamin K deficiency a newborn will present with melena, hematuria and
bleeding from umbilucs
activation of extrinsic pathway for coagulation is initiated by - ANSWERTissue
thromboplastin
PT and INR - ANSWERmeasure integrity of extrinsic pathway
PTT - ANSWERassesses the intrinsic pathway of coagulation
Von Willebrand Factor impairs - ANSWERplatelet adhesion to injured tissue
electrolyte imbalance causing clotting disorders - ANSWERhypocalcemia
oxytocin - ANSWERproduced in the hypothalamic region
, hormone that causes uterine and milk duct contraction, release during sexual
activity
How are steroid hormones transported - ANSWERdiffused through cell
membranes to activate intracellular receptors
lipid soluble hormones - ANSWERthyroid hormones
secondary endocrine disorder ex - ANSWERpituitary hyposecretion of TSH
upregulation of target cell receptors results in - ANSWERincreased target cell
responsiveness to hormone
Downregulation - ANSWERdecreased target cell sensitivity
Growth hormone - ANSWERincreases lean body mass
Stimulates liver to release IGF-1
Somatostatin supresses normal secretion of growth hormone
-infants would have normal birth length and weight
-Excess leads to acromegaly
pathophysiology Full Comprehensive
Questions with Verified Ans
why does cancer come back - ANSWERsmall areas of metastases can lie
dormant only to explode in growth later
Complete remission of leukemia is when less then 5% blasts in marrow and
normal CBC values
malignant neoplasm of epithelial origin are known as - ANSWERcarcinomas
Burkitt lymphoma is most closely associated with - ANSWEREpstein-Barr virus
major cause of death from leukemic disease - ANSWERinfection
myeloma - ANSWERbence jones proteins in the urine
Renal insufficiency is common
elevated Ca levels, bone fractures common
,CML chronic lymphoid leukemia - ANSWER-bcr-abl translocation
-Philadelphia chromosome
-Fatigue, weight loss, abdominal discomfort, sweats
ALL Acute lymphoid leukemia - ANSWER-best prognosis for long term disease
free survival
-Primarily affects children
-activity restriction with thrombocytopenia
-Common complication is infection
-anemia, leukocytosis, thrombocytopenia, pain in long bones, fever, painless
enlarged cervical lymph nodes
non-Hodgkin lymphoma - ANSWERthere may be gastrointestinal tract
involvement
CLL Chronic lymphoid leukemia - ANSWER
AML Acute myeloid leukemia - ANSWER
,Hemophilia A - ANSWERtreatment includes Factory VIII replacement
Hemophilia B - ANSWERdeficiency in factor IX
Final step in clot formation - ANSWERclot retraction
cause for bleeding with normal platelet cound, increased PT and INR -
ANSWERVitamin K deficiency
clotting factor deficiency from the liver
Vitamin K deficiency a newborn will present with melena, hematuria and
bleeding from umbilucs
activation of extrinsic pathway for coagulation is initiated by - ANSWERTissue
thromboplastin
PT and INR - ANSWERmeasure integrity of extrinsic pathway
PTT - ANSWERassesses the intrinsic pathway of coagulation
Von Willebrand Factor impairs - ANSWERplatelet adhesion to injured tissue
electrolyte imbalance causing clotting disorders - ANSWERhypocalcemia
oxytocin - ANSWERproduced in the hypothalamic region
, hormone that causes uterine and milk duct contraction, release during sexual
activity
How are steroid hormones transported - ANSWERdiffused through cell
membranes to activate intracellular receptors
lipid soluble hormones - ANSWERthyroid hormones
secondary endocrine disorder ex - ANSWERpituitary hyposecretion of TSH
upregulation of target cell receptors results in - ANSWERincreased target cell
responsiveness to hormone
Downregulation - ANSWERdecreased target cell sensitivity
Growth hormone - ANSWERincreases lean body mass
Stimulates liver to release IGF-1
Somatostatin supresses normal secretion of growth hormone
-infants would have normal birth length and weight
-Excess leads to acromegaly
