Hematology Complete Exam Study Guide
2026 | 130+ Questions & Answers with
Detailed Explanations | Guaranteed Pass
Exam Prep
Description
This complete exam study guide contains 130+ carefully structured
questions and answers designed to help students master the most
important exam topics and achieve outstanding results. Each question is
accompanied by a clear and detailed explanation, making it easier to
understand key concepts and strengthen exam preparation.
The guide is organized in a simple and student-friendly format,
allowing learners to review essential material quickly while practicing
realistic exam-style questions. By working through these 130+ Q&A,
students can reinforce their knowledge, identify important topics, and
improve their confidence before taking the exam.
This resource is ideal for final exam revision, self-testing, and
comprehensive exam preparation, making it a valuable tool for
students who want a reliable study guide and a higher chance of
passing their exam successfully.
List three ways to describe the genetic abnormality in CML? -answer ✅✅✅✅922 -
BCR-ABL gene - Philadelphia chromosome
What leukemia would lymphoblast be associated with? -answer ✅✅✅✅ALL (Blasts =
Acute)
,What leukemia would myeloblasts be associated with? -answer ✅✅✅✅AML (Blasts =
Acute)
What gene mutation is associated with polycythemia vera? -answer ✅✅✅✅JAK2
mutation
TTP symptom Mnemonic: FAT-RN. What dose FAT-RN stand for? -answer
✅✅✅✅Fever - Anemia - Thrombocytopenia - Renal failure - Neurologic involvement
List two conditions which predispose a patient to antiphospholipid syndrome. -answer
✅✅✅✅Systemic Lupus Erythematosus - Women with recurrent abortions
What disorder is a hemoglobin electrophoresis result of "SA" indicative of? -answer
✅✅✅✅Sickle cell trait
What disorder is a hemoglobin electrophoresis result of "SS" indicative of? -answer
✅✅✅✅Sickle cell disease
What type of anemia are cephalosporins PCN NSAIDS methyldopa associated with? -
answer ✅✅✅✅Immune hemolytic anemia
Erythropoietin analogs should be suspended once the hemoglobin is >_____? -answer
✅✅✅✅11 mg/dl
Erythropoietin analogs should only be initiated if the hemoglobin is < ____? -answer
✅✅✅✅10 mg/dl
What two types of anemia have macroovalocytes? -answer ✅✅✅✅B12 and folate
deficiency
Which anemia has a decreased MCV, decreased MCH (hypochromic) yet normal TIBC
and ferritin? -answer ✅✅✅✅Thalassemia
Acute chest syndrome occurs during the acute phase of which anemia? -answer
✅✅✅✅Hemolytic sickle cell crisis
What are some common oxidative events which may trigger hemolysis in G6PD
deficiency? -answer ✅✅✅✅Antimalarials - Sulfa drugs - Aspirin - Febrile Illness -
Acidosis - Fava beans
What type of anemia does a + osmotic fragility test indicate? -answer
✅✅✅✅Hereditary Spherocytosis
, What do an increased LDH, decreased Haptoglobin and an increased indirect Bilirubin
represent? -answer ✅✅✅✅Hemolysis
What type of anemia does a + direct coombs indicate? -answer ✅✅✅✅Autoimmune
hemolytic anemia
What does a > 50% reduction in platelet count within 7-10 days of exposure to heparin
define? -answer ✅✅✅✅Heparin Induced Thrombocytopenia (HIT) syndrome
Which type of anemia is most likely with associated leukopenia and thrombocytopenia?
-answer ✅✅✅✅Aplastic anemia
How would you expect TIBC and ferritin to present in anemia of chronic disease? -
answer ✅✅✅✅Decreased TIBC - Normal/increased Ferritin
Anemia of renal failure is defined by decreased levels of which hormone? -answer
✅✅✅✅Erythropoietin
Can oral B12 be used as an initial treatment in a B12 deficient patient? -answer
✅✅✅✅Yes - Oral B12 is considered initial therapy - Other routes if oral fails or
pernicious anemia is diagnosed
Which route is best for administering B12 to a deficient patient? -answer
✅✅✅✅Sublingual IM or deep subcutaneous
What tests other than a Schilling test are used to diagnose pernicious anemia? -answer
✅✅✅✅Increased Methylmalonic acid levels - + Intrinsic factor and parietal cell
antibodies
Increased MCV with smooth tongue, loss of proprioception and vibratory sense is likely
which type of anemia? -answer ✅✅✅✅B12 deficiency
List 5 common causes of folate deficiency. -answer ✅✅✅✅EtOH abuse - Advancing
age - Gastric bypass - Pregnancy - Methotrexate
What symptom differentiates B12 from folate deficiency ? -answer ✅✅✅✅Neuropathy
occurs with B12 deficiency but not with folate deficiency
Slowly decreasing MCV in an elderly patient? -answer ✅✅✅✅Occult GI blood loss
Pica is a specific symptom of which type of anemia? -answer ✅✅✅✅Iron deficiency
anemia
Decreased Ferritin and Increased TIBC? -answer ✅✅✅✅Iron deficiency anemia
2026 | 130+ Questions & Answers with
Detailed Explanations | Guaranteed Pass
Exam Prep
Description
This complete exam study guide contains 130+ carefully structured
questions and answers designed to help students master the most
important exam topics and achieve outstanding results. Each question is
accompanied by a clear and detailed explanation, making it easier to
understand key concepts and strengthen exam preparation.
The guide is organized in a simple and student-friendly format,
allowing learners to review essential material quickly while practicing
realistic exam-style questions. By working through these 130+ Q&A,
students can reinforce their knowledge, identify important topics, and
improve their confidence before taking the exam.
This resource is ideal for final exam revision, self-testing, and
comprehensive exam preparation, making it a valuable tool for
students who want a reliable study guide and a higher chance of
passing their exam successfully.
List three ways to describe the genetic abnormality in CML? -answer ✅✅✅✅922 -
BCR-ABL gene - Philadelphia chromosome
What leukemia would lymphoblast be associated with? -answer ✅✅✅✅ALL (Blasts =
Acute)
,What leukemia would myeloblasts be associated with? -answer ✅✅✅✅AML (Blasts =
Acute)
What gene mutation is associated with polycythemia vera? -answer ✅✅✅✅JAK2
mutation
TTP symptom Mnemonic: FAT-RN. What dose FAT-RN stand for? -answer
✅✅✅✅Fever - Anemia - Thrombocytopenia - Renal failure - Neurologic involvement
List two conditions which predispose a patient to antiphospholipid syndrome. -answer
✅✅✅✅Systemic Lupus Erythematosus - Women with recurrent abortions
What disorder is a hemoglobin electrophoresis result of "SA" indicative of? -answer
✅✅✅✅Sickle cell trait
What disorder is a hemoglobin electrophoresis result of "SS" indicative of? -answer
✅✅✅✅Sickle cell disease
What type of anemia are cephalosporins PCN NSAIDS methyldopa associated with? -
answer ✅✅✅✅Immune hemolytic anemia
Erythropoietin analogs should be suspended once the hemoglobin is >_____? -answer
✅✅✅✅11 mg/dl
Erythropoietin analogs should only be initiated if the hemoglobin is < ____? -answer
✅✅✅✅10 mg/dl
What two types of anemia have macroovalocytes? -answer ✅✅✅✅B12 and folate
deficiency
Which anemia has a decreased MCV, decreased MCH (hypochromic) yet normal TIBC
and ferritin? -answer ✅✅✅✅Thalassemia
Acute chest syndrome occurs during the acute phase of which anemia? -answer
✅✅✅✅Hemolytic sickle cell crisis
What are some common oxidative events which may trigger hemolysis in G6PD
deficiency? -answer ✅✅✅✅Antimalarials - Sulfa drugs - Aspirin - Febrile Illness -
Acidosis - Fava beans
What type of anemia does a + osmotic fragility test indicate? -answer
✅✅✅✅Hereditary Spherocytosis
, What do an increased LDH, decreased Haptoglobin and an increased indirect Bilirubin
represent? -answer ✅✅✅✅Hemolysis
What type of anemia does a + direct coombs indicate? -answer ✅✅✅✅Autoimmune
hemolytic anemia
What does a > 50% reduction in platelet count within 7-10 days of exposure to heparin
define? -answer ✅✅✅✅Heparin Induced Thrombocytopenia (HIT) syndrome
Which type of anemia is most likely with associated leukopenia and thrombocytopenia?
-answer ✅✅✅✅Aplastic anemia
How would you expect TIBC and ferritin to present in anemia of chronic disease? -
answer ✅✅✅✅Decreased TIBC - Normal/increased Ferritin
Anemia of renal failure is defined by decreased levels of which hormone? -answer
✅✅✅✅Erythropoietin
Can oral B12 be used as an initial treatment in a B12 deficient patient? -answer
✅✅✅✅Yes - Oral B12 is considered initial therapy - Other routes if oral fails or
pernicious anemia is diagnosed
Which route is best for administering B12 to a deficient patient? -answer
✅✅✅✅Sublingual IM or deep subcutaneous
What tests other than a Schilling test are used to diagnose pernicious anemia? -answer
✅✅✅✅Increased Methylmalonic acid levels - + Intrinsic factor and parietal cell
antibodies
Increased MCV with smooth tongue, loss of proprioception and vibratory sense is likely
which type of anemia? -answer ✅✅✅✅B12 deficiency
List 5 common causes of folate deficiency. -answer ✅✅✅✅EtOH abuse - Advancing
age - Gastric bypass - Pregnancy - Methotrexate
What symptom differentiates B12 from folate deficiency ? -answer ✅✅✅✅Neuropathy
occurs with B12 deficiency but not with folate deficiency
Slowly decreasing MCV in an elderly patient? -answer ✅✅✅✅Occult GI blood loss
Pica is a specific symptom of which type of anemia? -answer ✅✅✅✅Iron deficiency
anemia
Decreased Ferritin and Increased TIBC? -answer ✅✅✅✅Iron deficiency anemia
