NURS 5334 Advanced Pharmacology Final
Assessment Questions and Answers
1.
Which term describes how the body affects a drug?
A. Pharmacodynamics
B. Pharmacokinetics
B. Bioavailability
C. Therapeutics
Rationale: Pharmacokinetics = absorption, distribution, metabolism, excretion.
Pharmacodynamics = drug effect on body.
2.
Which antibiotic is contraindicated in children due to tooth discoloration?
A. Penicillin
B. Tetracycline
B. Cephalosporin
C. Macrolide
Rationale: Tetracyclines bind calcium in developing teeth → permanent discoloration.
3.
First-line therapy for hypertension in African American patients (without CKD)?
A. ACE inhibitors
B. Thiazide diuretics or CCBs
B. Beta-blockers
C. ARBs
Rationale: Evidence shows thiazides/CCBs more effective in this population.
4.
Which drug requires monitoring of INR?
A. Heparin
B. Warfarin
B. Dabigatran
C. Aspirin
Rationale: Warfarin’s effect measured by INR; heparin monitored with aPTT.
5.
Which opioid antagonist reverses respiratory depression?
A. Morphine
B. Methadone
C. Naloxone
C. Buprenorphine
Rationale: Naloxone competitively blocks opioid receptors.
, 6.
Which drug class is most associated with dry cough?
A. ARBs
B. ACE inhibitors
B. Beta-blockers
C. Calcium channel blockers
Rationale: ACE inhibitors ↑ bradykinin → cough.
7.
Which insulin has the fastest onset?
A. NPH
B. Regular insulin
C. Lispro (Humalog)
C. Glargine
Rationale: Lispro is rapid-acting, onset ~15 min.
8.
Which drug is contraindicated in asthma?
A. CCBs
B. ACE inhibitors
C. Non-selective beta-blockers
C. ARBs
Rationale: Non-selective beta-blockers block β2 → bronchospasm.
9.
Which antibiotic is safe in pregnancy?
A. Tetracycline
B. Fluoroquinolone
C. Penicillin
C. Aminoglycoside
Rationale: Penicillins are safe; tetracyclines/fluoroquinolones contraindicated.
10.
Which drug is used for status epilepticus?
A. Phenytoin
B. Lorazepam
B. Carbamazepine
C. Valproic acid
Rationale: Benzodiazepines (lorazepam/diazepam) are first-line.
11.
Which antidepressant has the highest risk of serotonin syndrome when combined with
MAOIs?
A. TCA
B. SSRI
B. SNRI
Assessment Questions and Answers
1.
Which term describes how the body affects a drug?
A. Pharmacodynamics
B. Pharmacokinetics
B. Bioavailability
C. Therapeutics
Rationale: Pharmacokinetics = absorption, distribution, metabolism, excretion.
Pharmacodynamics = drug effect on body.
2.
Which antibiotic is contraindicated in children due to tooth discoloration?
A. Penicillin
B. Tetracycline
B. Cephalosporin
C. Macrolide
Rationale: Tetracyclines bind calcium in developing teeth → permanent discoloration.
3.
First-line therapy for hypertension in African American patients (without CKD)?
A. ACE inhibitors
B. Thiazide diuretics or CCBs
B. Beta-blockers
C. ARBs
Rationale: Evidence shows thiazides/CCBs more effective in this population.
4.
Which drug requires monitoring of INR?
A. Heparin
B. Warfarin
B. Dabigatran
C. Aspirin
Rationale: Warfarin’s effect measured by INR; heparin monitored with aPTT.
5.
Which opioid antagonist reverses respiratory depression?
A. Morphine
B. Methadone
C. Naloxone
C. Buprenorphine
Rationale: Naloxone competitively blocks opioid receptors.
, 6.
Which drug class is most associated with dry cough?
A. ARBs
B. ACE inhibitors
B. Beta-blockers
C. Calcium channel blockers
Rationale: ACE inhibitors ↑ bradykinin → cough.
7.
Which insulin has the fastest onset?
A. NPH
B. Regular insulin
C. Lispro (Humalog)
C. Glargine
Rationale: Lispro is rapid-acting, onset ~15 min.
8.
Which drug is contraindicated in asthma?
A. CCBs
B. ACE inhibitors
C. Non-selective beta-blockers
C. ARBs
Rationale: Non-selective beta-blockers block β2 → bronchospasm.
9.
Which antibiotic is safe in pregnancy?
A. Tetracycline
B. Fluoroquinolone
C. Penicillin
C. Aminoglycoside
Rationale: Penicillins are safe; tetracyclines/fluoroquinolones contraindicated.
10.
Which drug is used for status epilepticus?
A. Phenytoin
B. Lorazepam
B. Carbamazepine
C. Valproic acid
Rationale: Benzodiazepines (lorazepam/diazepam) are first-line.
11.
Which antidepressant has the highest risk of serotonin syndrome when combined with
MAOIs?
A. TCA
B. SSRI
B. SNRI
