Nurs 316 Final Exam 1 – Questions With
Comprehensive Solutions
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Terms in this set (85)
Potency the AMOUNT of drug necessary to produce the
desired effect
Efficacy the ABILITY of the drug to achieve the desired effect
What is the FDA? When was it
empowered? What was it empowered
to enforce? What are the primary
responsibilities of the FDA?
What are the four (4) processes 1. Absorption
involved with the movement of drugs 2. Distribution
inside the body? 3. Metabolism
4. Excretion
How does the route of administration • Drugs that are administered IM or SQ are absorbed
effect the action of a drug in a by the small capillaries fairly rapidly
patient? • Drugs that are administered oral take the longest to
be absorbed
• Drugs that are administered IV do not need to be
absorbed and are instantly absorbed
What does the amount of protein • The % of drug bound to albumin is determined by
binding have to do with a drugs rate strength of attraction between them
of distribution? Rate of excretion? • Only un-bound (free) drugs can leave the vascular
space and reach target tissues
• The portion of the drug that is protein bound is
inactive
• Only free drugs are active drugs that can exert a
pharmacological effect
, Which type of drug is excreted by the • Lipid soluble drugs are converted by the liver to
kidney with greater ease? (fat-soluble water soluble forms for renal excretion
or water-soluble) • In kidneys, drugs in a lipid-soluble state will be
reabsorbed back into the blood
• ***So, water soluble drugs are excreted by the
kidney with greater ease
What is the primary organ responsible Liver
for drug metabolism?
Which drug will need to be dosed One with a short life span, because those are the
more frequently, one with a long half- light protein bound
life or one with a short half-life? Why?
What is the primary organ responsible Kidney
for drug excretion?
Glomerular filtration: is the process that your kidneys use to filter excess
fluid and waste products out of the blood into the
urine collecting tubules of the kidney, so they may be
eliminated from your body.
Tubular reabsorption: the process by which solutes and water are removed
from the tubular fluid and transported into the blood.
Tubular secretion: the transfer of materials from peritubular capillaries
to renal tubular lumen
How will drug excretion by affected in If patient has renal failure, then drug stays in the
a patient with renal dysfunction? What body longer and the patient is at risk for drug toxicity
risk does this place on the patient?
If someone has head trauma, will yes they will pass the BBB more easily
drugs pass the BBB easily or no?
Comprehensive Solutions
Save
Terms in this set (85)
Potency the AMOUNT of drug necessary to produce the
desired effect
Efficacy the ABILITY of the drug to achieve the desired effect
What is the FDA? When was it
empowered? What was it empowered
to enforce? What are the primary
responsibilities of the FDA?
What are the four (4) processes 1. Absorption
involved with the movement of drugs 2. Distribution
inside the body? 3. Metabolism
4. Excretion
How does the route of administration • Drugs that are administered IM or SQ are absorbed
effect the action of a drug in a by the small capillaries fairly rapidly
patient? • Drugs that are administered oral take the longest to
be absorbed
• Drugs that are administered IV do not need to be
absorbed and are instantly absorbed
What does the amount of protein • The % of drug bound to albumin is determined by
binding have to do with a drugs rate strength of attraction between them
of distribution? Rate of excretion? • Only un-bound (free) drugs can leave the vascular
space and reach target tissues
• The portion of the drug that is protein bound is
inactive
• Only free drugs are active drugs that can exert a
pharmacological effect
, Which type of drug is excreted by the • Lipid soluble drugs are converted by the liver to
kidney with greater ease? (fat-soluble water soluble forms for renal excretion
or water-soluble) • In kidneys, drugs in a lipid-soluble state will be
reabsorbed back into the blood
• ***So, water soluble drugs are excreted by the
kidney with greater ease
What is the primary organ responsible Liver
for drug metabolism?
Which drug will need to be dosed One with a short life span, because those are the
more frequently, one with a long half- light protein bound
life or one with a short half-life? Why?
What is the primary organ responsible Kidney
for drug excretion?
Glomerular filtration: is the process that your kidneys use to filter excess
fluid and waste products out of the blood into the
urine collecting tubules of the kidney, so they may be
eliminated from your body.
Tubular reabsorption: the process by which solutes and water are removed
from the tubular fluid and transported into the blood.
Tubular secretion: the transfer of materials from peritubular capillaries
to renal tubular lumen
How will drug excretion by affected in If patient has renal failure, then drug stays in the
a patient with renal dysfunction? What body longer and the patient is at risk for drug toxicity
risk does this place on the patient?
If someone has head trauma, will yes they will pass the BBB more easily
drugs pass the BBB easily or no?
