PCB 4233 FINAL EXAM QUESTONS AND ANSWERS
Which of the following is not associated with allergy development early in life?
a) decreased animal exposure
b) decreased siblingship
c) bottle feeding
d) teething - Answers -Answer: d) teething
What is the primary immune response which is responsible for dealing with helminths?
a) Tc cell-mediated
b) TH2 cell-mediated
c) Plasma cell-mediated
d) Humoral (antibody)
e) Complement - Answers -Answer: b) TH2 cell-mediated
Infection by which of the following worm species is most associated with the developed
world?
A. - Necator americanus (Hookworm)
B. - Strongyloides stercoralis
C. - Trichuris trichiura (Whipworm)
D. - Enterobius vermicularis (Pinworm) - Answers -Answer - D
Which of the following statements correctly explains the immune response to
Schistosomes?
A. TH1 responses predominate in the early stage of infection while TH2 responses
predominate in the chronic stage of infection
B. TH1 responses predominate in the chronic stage of infection while TH2 responses
predominate in the early stage of infection
C. TH1 responses lead to increases in pathology with the worms
D. Granulomas increase upon TH1 and TH2 responses
,E. None of the above statements correctly describe this immune response - Answers -
Correct answer is (A
Exiting the thymus seems to depend on a cascade involving the transcription factor,
Foxo1, which does NOT lead to production of
A. SIPR, which allows thymic egress
B. IL-7R, which promotes survival of the cells
C. CCR7, a chemokine receptor that directs cells to lymph nodes
D. CD3, which allows cell surface T-cell receptor expression
E. It leads to all of the above. - Answers -Correct answer: D. CD3, which allows cell
surface T-cell receptor expression.
The extrinsic pathway:
a. does NOT depend on the activation of protease activity
b. depends on failure of mitochondrial integrity
c. is initiated by death receptors
d. all of the above - Answers -Correct answer is C.
The extrinsic pathway does get initiated by death receptors and DOES depend on the
activation of protease activity. But, the extrinsic pathway does not depend on failure of
mitochondrial integrity.
The Extrinsic Pathway does Not:
A) Depends on Failure of mitochondrial integrity
B) Get initiated by death receptors
C) Depend on activation of protease activity
D) Explain the phenomenon of activation induced cell death
E) All the Above - Answers -The Correct answer is A)
Which Ig is best associated with gut microbiota functions?
A) IgA
, B) IgG
C) IgD
D) IgE - Answers -Answer: A) IgA
Which of the following helminths replicates within the human host?
A. Ascariasis lumbricodes
B. Trichuris trichuria
C. Strongyloides stercoralis
D. Necator americanus - Answers -Answer is C
True or False:
The hygiene hypothesis states that those who live in cleaner environments are less
susceptible to allergy and autoimmune diseases. - Answers -Answer: False, The
hygiene hypothesis states that overly clean environments result in an under-stimulated
immune system that doesn't respond appropriately to antigens. It has been shown that
there is actually an increase of allergy and autoimmune disease in cleaner
environments, possibly because people are not exposed to certain antigens, and
therefore do not amount a specific immune response.
Which immunoglobulin is the most prominent in breast milk?
IgM
IgG
IgA
IgE - Answers -IgA
Experiment: Researchers analyzed the thymocytes from normal H-2b mice, which have
a deletion of the class II IE gene, and from H-2b mice in which the class II IA gene had
been knocked out.
Question: What MHC molecules would you find on antigen-presenting cells from the
normal H-2b mice?
***** - Answers -Answer: Class I K, D, and L molecules and class II IA molecules.
Which of the following is not associated with allergy development early in life?
a) decreased animal exposure
b) decreased siblingship
c) bottle feeding
d) teething - Answers -Answer: d) teething
What is the primary immune response which is responsible for dealing with helminths?
a) Tc cell-mediated
b) TH2 cell-mediated
c) Plasma cell-mediated
d) Humoral (antibody)
e) Complement - Answers -Answer: b) TH2 cell-mediated
Infection by which of the following worm species is most associated with the developed
world?
A. - Necator americanus (Hookworm)
B. - Strongyloides stercoralis
C. - Trichuris trichiura (Whipworm)
D. - Enterobius vermicularis (Pinworm) - Answers -Answer - D
Which of the following statements correctly explains the immune response to
Schistosomes?
A. TH1 responses predominate in the early stage of infection while TH2 responses
predominate in the chronic stage of infection
B. TH1 responses predominate in the chronic stage of infection while TH2 responses
predominate in the early stage of infection
C. TH1 responses lead to increases in pathology with the worms
D. Granulomas increase upon TH1 and TH2 responses
,E. None of the above statements correctly describe this immune response - Answers -
Correct answer is (A
Exiting the thymus seems to depend on a cascade involving the transcription factor,
Foxo1, which does NOT lead to production of
A. SIPR, which allows thymic egress
B. IL-7R, which promotes survival of the cells
C. CCR7, a chemokine receptor that directs cells to lymph nodes
D. CD3, which allows cell surface T-cell receptor expression
E. It leads to all of the above. - Answers -Correct answer: D. CD3, which allows cell
surface T-cell receptor expression.
The extrinsic pathway:
a. does NOT depend on the activation of protease activity
b. depends on failure of mitochondrial integrity
c. is initiated by death receptors
d. all of the above - Answers -Correct answer is C.
The extrinsic pathway does get initiated by death receptors and DOES depend on the
activation of protease activity. But, the extrinsic pathway does not depend on failure of
mitochondrial integrity.
The Extrinsic Pathway does Not:
A) Depends on Failure of mitochondrial integrity
B) Get initiated by death receptors
C) Depend on activation of protease activity
D) Explain the phenomenon of activation induced cell death
E) All the Above - Answers -The Correct answer is A)
Which Ig is best associated with gut microbiota functions?
A) IgA
, B) IgG
C) IgD
D) IgE - Answers -Answer: A) IgA
Which of the following helminths replicates within the human host?
A. Ascariasis lumbricodes
B. Trichuris trichuria
C. Strongyloides stercoralis
D. Necator americanus - Answers -Answer is C
True or False:
The hygiene hypothesis states that those who live in cleaner environments are less
susceptible to allergy and autoimmune diseases. - Answers -Answer: False, The
hygiene hypothesis states that overly clean environments result in an under-stimulated
immune system that doesn't respond appropriately to antigens. It has been shown that
there is actually an increase of allergy and autoimmune disease in cleaner
environments, possibly because people are not exposed to certain antigens, and
therefore do not amount a specific immune response.
Which immunoglobulin is the most prominent in breast milk?
IgM
IgG
IgA
IgE - Answers -IgA
Experiment: Researchers analyzed the thymocytes from normal H-2b mice, which have
a deletion of the class II IE gene, and from H-2b mice in which the class II IA gene had
been knocked out.
Question: What MHC molecules would you find on antigen-presenting cells from the
normal H-2b mice?
***** - Answers -Answer: Class I K, D, and L molecules and class II IA molecules.
