PSY 627 COMPREHENSIVE STUDY GUIDE 2026 FULL
QUESTIONS AND SOLUTIONS GRADED A+
● Enteral. Answer: via the gastrointestinal tract SLOWER onset because it must pass
through stomach and liver where it is metabolized
● Parenteral. Answer: avoids the GI tract and first pass metabolism FASTER onset 4 Types:
1. Inhaled 2. Transmucosal 3. Injected 4. Transdermal
● If a receptor is in a resting state, adding a partial agonist will have a net. Answer:
partial agonist effect
● If a receptor is fully active, adding a partial agonist will have a net. Answer: antagonist
effect
● If an antagonist is present, adding a partial agonist will. Answer: diminish the
antagonistic effect
● Psychotic symptoms, including the positive symptoms of schizophrenia, are
associated with hyperactivity of dopamine (DA) in which pathway?. Answer:
Mesolimbic/mesostriatal pathway
● Cognitive, negative and affective symptoms are associated with hypoactivity of
dopamine (DA) in which pathway?. Answer: Mesocortical dopamine pathway
● Serotonin hyperactivity/imbalance at 5-HT2A receptors on one population of Glu
neurons in the cortex projecting to DA neurons the mesencephalon causes
_____________________________.. Answer: positive symptoms and psychosis in general.
● Amenorrhea and galactorrhea may be caused by antagonism of D2 receptors in
which pathway?. Answer: The Tuberoinfundibular Dopamine Pathway
● What are the two types of abnormal muscle movements caused by D2 antagonists?.
Answer: 1. Acute dystonia 2. drug induced parkinsons
● What are the symptoms/signs of akathisia? Can it be a serious SE for some patients?
Is its exact pathophysiology fully known? It has been most commonly associated with
the use of drugs with antipsychotic effects, but it may be caused by other classes of
drugs.. Answer: restlessness, pacing, anxiety, agitation - Patients often do not tell doctors
QUESTIONS AND SOLUTIONS GRADED A+
● Enteral. Answer: via the gastrointestinal tract SLOWER onset because it must pass
through stomach and liver where it is metabolized
● Parenteral. Answer: avoids the GI tract and first pass metabolism FASTER onset 4 Types:
1. Inhaled 2. Transmucosal 3. Injected 4. Transdermal
● If a receptor is in a resting state, adding a partial agonist will have a net. Answer:
partial agonist effect
● If a receptor is fully active, adding a partial agonist will have a net. Answer: antagonist
effect
● If an antagonist is present, adding a partial agonist will. Answer: diminish the
antagonistic effect
● Psychotic symptoms, including the positive symptoms of schizophrenia, are
associated with hyperactivity of dopamine (DA) in which pathway?. Answer:
Mesolimbic/mesostriatal pathway
● Cognitive, negative and affective symptoms are associated with hypoactivity of
dopamine (DA) in which pathway?. Answer: Mesocortical dopamine pathway
● Serotonin hyperactivity/imbalance at 5-HT2A receptors on one population of Glu
neurons in the cortex projecting to DA neurons the mesencephalon causes
_____________________________.. Answer: positive symptoms and psychosis in general.
● Amenorrhea and galactorrhea may be caused by antagonism of D2 receptors in
which pathway?. Answer: The Tuberoinfundibular Dopamine Pathway
● What are the two types of abnormal muscle movements caused by D2 antagonists?.
Answer: 1. Acute dystonia 2. drug induced parkinsons
● What are the symptoms/signs of akathisia? Can it be a serious SE for some patients?
Is its exact pathophysiology fully known? It has been most commonly associated with
the use of drugs with antipsychotic effects, but it may be caused by other classes of
drugs.. Answer: restlessness, pacing, anxiety, agitation - Patients often do not tell doctors
