POST UIZ 3| TOP SCORES MADE SIMPLE | TRUSTED TEST
SOLUTIONS!
A 20-year-old man presents to his primary care physician's office with complaints of
fever, fatigue and weight loss for the last month. He began to feel poorly about two
months ago but attributed his symptoms to a demanding schedule at college. He
complains of fevers and sweats at night for the last two weeks, such that he "soaks" his
sheets. His appetite is poor and he has a dry cough. He has no medical problems and
takes Tylenol as needed for the fevers.
- He has bilateral anterior cervical and supraclavicular adenopathy. The lymph nodes
are 2 cm, firm, rubbery, mobile and nontender. He has no other palpable adenopathy.
- Reed-Sternberg Cells are seen histologically
Diagnosis? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma panthognomic finding Answer: Reed-Sternberg Cells
Reed-Sternberg Cells Answer: Hodgkin's lymphoma
Bilateral anterior cervical and supraclavicular adenopathy with lymph nodes that are 2
cm, firm, rubbery, mobile and nontender
- Clinical manifestations of? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma clinical manifestations Answer: B-Symptoms:
• Fever, night sweats, weight loss
• Generalized pruritus
Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal lymph nodes and
the spleen
Hematogenous spread
• Bone marrow
• Liver
• Lung
1
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,Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal
lymph nodes and the spleen Answer: Hodgkin's lymphoma
B-Symptoms:
• Fever, night sweats, weight loss
• Generalized pruritus
Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal lymph nodes and
the spleen
Hematogenous spread
• Bone marrow
• Liver
• Lung
Clinical manifestations of? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma genetics Answer: Malignant B-cell lineage
Malignant B-cell lineage can cause what malignancy Answer: Hodgkin's lymphoma
What malignancy has a Bimodal distribution Answer: Hodgkin's lymphoma
Hodgkin's lymphoma epidemiology Answer: Bimodal distribution
- Patients ages 15 and 35 or older than 60
You are on a medical mission trip to Liberia, Africa. Your first
patient is a 12 year-old child with massive right sided facial
swelling which developed over about 10 days. He complains
of fever, difficulty swallowing and now has a cough. He is hospitalized and the jaw mass
is biopsied and shows a "starry sky" appearance
Diagnosis? Answer: Burkitt's Lymphoma
2
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, Burkitt's Lymphoma clinical manifestations Answer: - Endemic (African) form: Jaw and
facial bone tumor; Rapid spread: extranodal site including bone marrow, CNS
- Non endemic form: Massive ascites, intraabdominal spread, bone marrow, CNS
- Endemic (African) form: Jaw and facial bone tumor; Rapid spread: extranodal site
including bone marrow, CNS
- Non endemic form: Massive ascites, intraabdominal spread, bone marrow, CNS
Clinical manifestations of? Answer: Burkitt's Lymphoma
Burkitt's Lymphoma genetics Answer: t(8;14) translocation of c-myc gene
t(8;14) translocation of c-myc gene Answer: Burkitt's Lymphoma
t(8;14) Answer: Burkitt's Lymphoma
c-myc Answer: Burkitt's Lymphoma
What lymphoma is associated with EBV infection Answer: - Burkitt's Lymphoma
- Primary CNS Lymphoma
Jaw and facial bone tumor; Rapid spread: extranodal site, including bone marrow, CNS,
are the clinical manifestations of what type of Burkitt's Lymphoma Answer: Endemic
(African) form
Massive ascites, intra-abdominal spread, bone marrow, CNS are the clinical
manifestations of what type of Burkitt's Lymphoma Answer: Non-endemic form
Background of medium-sized cells with round nuclei plus macrophages containing
stainable "tingible" phagocytosed cells being degraded are seen in what Lymphoma?
Answer: Burkitt's Lymphoma
"Starry sky" appearance Answer: Burkitt's Lymphoma
Burkitt's Lymphoma histological findings Answer: "Starry sky" appearance
- Background of medium-sized cells with round nuclei plus macrophages containing
stainable "tingible" phagocytosed cells being degraded
Burkitt's Lymphoma is [aggressive/indolent] Answer: aggressive
A 70-year-old man presents to his physician's office at the insistence of his wife due to
poor energy, poor appetite and weight loss. The patient is too weak to provide further
history. His exam is significant for multiple 2-cm firm, rubbery lymph nodes in the right
supraclavicular fossa, left axilla, and right inguinal region. An axillary lymph node is
3
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SOLUTIONS!
A 20-year-old man presents to his primary care physician's office with complaints of
fever, fatigue and weight loss for the last month. He began to feel poorly about two
months ago but attributed his symptoms to a demanding schedule at college. He
complains of fevers and sweats at night for the last two weeks, such that he "soaks" his
sheets. His appetite is poor and he has a dry cough. He has no medical problems and
takes Tylenol as needed for the fevers.
- He has bilateral anterior cervical and supraclavicular adenopathy. The lymph nodes
are 2 cm, firm, rubbery, mobile and nontender. He has no other palpable adenopathy.
- Reed-Sternberg Cells are seen histologically
Diagnosis? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma panthognomic finding Answer: Reed-Sternberg Cells
Reed-Sternberg Cells Answer: Hodgkin's lymphoma
Bilateral anterior cervical and supraclavicular adenopathy with lymph nodes that are 2
cm, firm, rubbery, mobile and nontender
- Clinical manifestations of? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma clinical manifestations Answer: B-Symptoms:
• Fever, night sweats, weight loss
• Generalized pruritus
Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal lymph nodes and
the spleen
Hematogenous spread
• Bone marrow
• Liver
• Lung
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
,Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal
lymph nodes and the spleen Answer: Hodgkin's lymphoma
B-Symptoms:
• Fever, night sweats, weight loss
• Generalized pruritus
Painless enlargement of lymph nodes
• Usually in starting in the neck or mediastinum
• Usually spreads to contiguous lymph nodes including retroperitoneal lymph nodes and
the spleen
Hematogenous spread
• Bone marrow
• Liver
• Lung
Clinical manifestations of? Answer: Hodgkin's lymphoma
Hodgkin's lymphoma genetics Answer: Malignant B-cell lineage
Malignant B-cell lineage can cause what malignancy Answer: Hodgkin's lymphoma
What malignancy has a Bimodal distribution Answer: Hodgkin's lymphoma
Hodgkin's lymphoma epidemiology Answer: Bimodal distribution
- Patients ages 15 and 35 or older than 60
You are on a medical mission trip to Liberia, Africa. Your first
patient is a 12 year-old child with massive right sided facial
swelling which developed over about 10 days. He complains
of fever, difficulty swallowing and now has a cough. He is hospitalized and the jaw mass
is biopsied and shows a "starry sky" appearance
Diagnosis? Answer: Burkitt's Lymphoma
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
, Burkitt's Lymphoma clinical manifestations Answer: - Endemic (African) form: Jaw and
facial bone tumor; Rapid spread: extranodal site including bone marrow, CNS
- Non endemic form: Massive ascites, intraabdominal spread, bone marrow, CNS
- Endemic (African) form: Jaw and facial bone tumor; Rapid spread: extranodal site
including bone marrow, CNS
- Non endemic form: Massive ascites, intraabdominal spread, bone marrow, CNS
Clinical manifestations of? Answer: Burkitt's Lymphoma
Burkitt's Lymphoma genetics Answer: t(8;14) translocation of c-myc gene
t(8;14) translocation of c-myc gene Answer: Burkitt's Lymphoma
t(8;14) Answer: Burkitt's Lymphoma
c-myc Answer: Burkitt's Lymphoma
What lymphoma is associated with EBV infection Answer: - Burkitt's Lymphoma
- Primary CNS Lymphoma
Jaw and facial bone tumor; Rapid spread: extranodal site, including bone marrow, CNS,
are the clinical manifestations of what type of Burkitt's Lymphoma Answer: Endemic
(African) form
Massive ascites, intra-abdominal spread, bone marrow, CNS are the clinical
manifestations of what type of Burkitt's Lymphoma Answer: Non-endemic form
Background of medium-sized cells with round nuclei plus macrophages containing
stainable "tingible" phagocytosed cells being degraded are seen in what Lymphoma?
Answer: Burkitt's Lymphoma
"Starry sky" appearance Answer: Burkitt's Lymphoma
Burkitt's Lymphoma histological findings Answer: "Starry sky" appearance
- Background of medium-sized cells with round nuclei plus macrophages containing
stainable "tingible" phagocytosed cells being degraded
Burkitt's Lymphoma is [aggressive/indolent] Answer: aggressive
A 70-year-old man presents to his physician's office at the insistence of his wife due to
poor energy, poor appetite and weight loss. The patient is too weak to provide further
history. His exam is significant for multiple 2-cm firm, rubbery lymph nodes in the right
supraclavicular fossa, left axilla, and right inguinal region. An axillary lymph node is
3
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