NR 565 Advanced Pharmacology Final Newest Exam
Preparation Newest With Complete Questions And
Correct Detailed Answers| Brand New Version
antacid drugs - - answer --Aluminum hydroxide, magnesium hydroxide
Antacid adverse effects - - answer --constipation (aluminum hydroxide) diarrhea
(magnesium hydroxide), sodium loading - be cautious giving to patients with HF,
HTN, and renal failure.
Histamine 2 receptor antagonists examples - - answer --Cimetidine
Ranitidine
Famotidine
Nizatidine
Histamine 2 Receptor Antagonists MOA - - answer --*reversibly* inhibit H2
receptors, which *decreases* gastric acid secretions
Cimetidine: Therapeutic Goal - - answer --To relieve pain, promote healing,
prevent ulcer recurrence, and prevent complications of PUD.
Cimetidine adverse effects - - answer --Decreased libido, impotence and CNS
effects (lethargy, depression and confusion), PNA, gynecomastia
,NSAID induced ulcer prophylaxis - - answer --PPI is preferred. Do not give H2
receptor blockers or antacids or Sucralfate. Misoprostol is the only approved
medication as prophylaxis against NSAID associated ulcers.
Misoprostol (Cytotec) - - answer --Prostaglandin E analog
Used w/ NSAIDs to prevent gastric ulcers
Can induce labor
Can cause diarrhea, abdominal pain, dysmenorrhea, spotting
Take w/ meals and at bedtime
laxative use during pregnancy - - answer --Use with caution - can induce labor
Osmotic laxatives examples - - answer --magnesium hydroxide, magnesium
citrate, polyethylene glycol, lactulose
Osmotic laxatives MOA - - answer --Provide osmotic load to draw water into the
GI lumen, which increases peristalsis, and causes fecal mass to swell and soften.
Osmotic laxatives contraindications - - answer --Sodium phosphate can increase
fluid retention, avoid in HF, edema, HTN. No magnesium salts with renal
impairment. All can cause substantial loss of water.
Lubiprostone MOA - - answer --Activates chloride channels in the gut, leading to
increased fluid in the gut and peristalsis
, Lubiprostone indications - - answer --Chronic constipation (idiopathic, IBS, opioid-
induced)
Opioids for diarrhea MOA - - answer --Activate opioid receptors in the intestinal
tract; slows peristalsis in the colon; decrease secretion of fluid I. The intestines.
Opioid examples for diarrhea - - answer --paregoric (tincture of opium- C3),
diphenoxylate or Lamotil, lopermide or Imodium,
Immunosuppressants for GI disorders - - answer --Used as long term therapy for
ulcerative colitis and crohn disease. Include drugs such as mercaptopurine,
influximab, azathioprine
Infliximab - - answer --anti TNF alpha mab - used for chronic inflammation
diseases. Monoclonal antibody. IV. Infections and transfusion reactions are most
common side effect.
Sulfasalazine (Azulfidine) indications - - answer --ulcerative colitis, may also
benefit patients with crohns.
Sulfasalazine MOA - - answer --A combination of sulfapyridine (antibacterial) and
5-aminosalicylic acid (anti-inflammatory). Activated by colonic bacteria.
Alosetron MOA - - answer --5-HT3 receptor antagonist in the intestines; increases
colonic transit time, decreases secretion of fluid into the intestines, increases
reabsorbtion of fluids and electrolytes to increase stool firmness and decrease
fecal urgency and frequency
Preparation Newest With Complete Questions And
Correct Detailed Answers| Brand New Version
antacid drugs - - answer --Aluminum hydroxide, magnesium hydroxide
Antacid adverse effects - - answer --constipation (aluminum hydroxide) diarrhea
(magnesium hydroxide), sodium loading - be cautious giving to patients with HF,
HTN, and renal failure.
Histamine 2 receptor antagonists examples - - answer --Cimetidine
Ranitidine
Famotidine
Nizatidine
Histamine 2 Receptor Antagonists MOA - - answer --*reversibly* inhibit H2
receptors, which *decreases* gastric acid secretions
Cimetidine: Therapeutic Goal - - answer --To relieve pain, promote healing,
prevent ulcer recurrence, and prevent complications of PUD.
Cimetidine adverse effects - - answer --Decreased libido, impotence and CNS
effects (lethargy, depression and confusion), PNA, gynecomastia
,NSAID induced ulcer prophylaxis - - answer --PPI is preferred. Do not give H2
receptor blockers or antacids or Sucralfate. Misoprostol is the only approved
medication as prophylaxis against NSAID associated ulcers.
Misoprostol (Cytotec) - - answer --Prostaglandin E analog
Used w/ NSAIDs to prevent gastric ulcers
Can induce labor
Can cause diarrhea, abdominal pain, dysmenorrhea, spotting
Take w/ meals and at bedtime
laxative use during pregnancy - - answer --Use with caution - can induce labor
Osmotic laxatives examples - - answer --magnesium hydroxide, magnesium
citrate, polyethylene glycol, lactulose
Osmotic laxatives MOA - - answer --Provide osmotic load to draw water into the
GI lumen, which increases peristalsis, and causes fecal mass to swell and soften.
Osmotic laxatives contraindications - - answer --Sodium phosphate can increase
fluid retention, avoid in HF, edema, HTN. No magnesium salts with renal
impairment. All can cause substantial loss of water.
Lubiprostone MOA - - answer --Activates chloride channels in the gut, leading to
increased fluid in the gut and peristalsis
, Lubiprostone indications - - answer --Chronic constipation (idiopathic, IBS, opioid-
induced)
Opioids for diarrhea MOA - - answer --Activate opioid receptors in the intestinal
tract; slows peristalsis in the colon; decrease secretion of fluid I. The intestines.
Opioid examples for diarrhea - - answer --paregoric (tincture of opium- C3),
diphenoxylate or Lamotil, lopermide or Imodium,
Immunosuppressants for GI disorders - - answer --Used as long term therapy for
ulcerative colitis and crohn disease. Include drugs such as mercaptopurine,
influximab, azathioprine
Infliximab - - answer --anti TNF alpha mab - used for chronic inflammation
diseases. Monoclonal antibody. IV. Infections and transfusion reactions are most
common side effect.
Sulfasalazine (Azulfidine) indications - - answer --ulcerative colitis, may also
benefit patients with crohns.
Sulfasalazine MOA - - answer --A combination of sulfapyridine (antibacterial) and
5-aminosalicylic acid (anti-inflammatory). Activated by colonic bacteria.
Alosetron MOA - - answer --5-HT3 receptor antagonist in the intestines; increases
colonic transit time, decreases secretion of fluid into the intestines, increases
reabsorbtion of fluids and electrolytes to increase stool firmness and decrease
fecal urgency and frequency
