CMN 548 Unit 5 UPDATED ACTUAL Questions and CORRECT
Answers
Potency refers to the relative dose required to achieve certain effects, not to the efficacy
of a drug
Agonist (full agonist) A drug that binds to a specific receptor producing an effect identical to that
usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics The time course and intensity of a drug's effect/what the drug does to the body
Pharmacokinetics What the body does to a drug
Tolerance Develops over time a need to use increased doses of a medication/drug to
maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome A systemic, immune-mediated reaction that can be fatal or result in permanent
scarring or blindness
Antagonist A compound that blinds to a receptor that blocks or reduces the action of
another substance at the receptor site
Hyponatremia Common symptoms of this medication side effect include confusion, agitation,
and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index ratio of the median toxic dose to the median effective dose
Somnolence Daytime sleepiness
Black Box Warning This warning reflects that a medication may cause a serious or even life-
threatening side effect
Partial or Mixed Agonist A compound that elicits a partial pharmacological response at the receptor site
involved
Remission The degree of improvement to below the syndromal threshold of a disorder
Paradoxical A response to a drug that represents the clinical effect opposite of what is
expected
Inverse agonist An agent that binds to the same receptor site as an agonist but produces the
opposite pharmacological effect
4 major transmitters Dopamine, Serotonin, GABA, Norepinephrine
, Dopamine transmitter affects? affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? Depression, aggression, OCD, Panic, GAD, Social Anxiety, PTSD, Violence, Sexual
dysfunction, substance addiction
Norepinephrine affects? Affects mood, anxiety, psychosis, ADHD (part), drug withdrawal
GABA affects? Fear, anxiety, worry
Irreversible MAOIs Types MAOa and MAOb
Irreversible MAOIs medications Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of because they irreversibly inactivate MAOs, the therapeutic effect of a single dose
MAO for how long? of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? orthostatic hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? Moclobemide (Maerix)
How long will it take to recover MAO activity after a final MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
dose of RIMA?
Answers
Potency refers to the relative dose required to achieve certain effects, not to the efficacy
of a drug
Agonist (full agonist) A drug that binds to a specific receptor producing an effect identical to that
usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics The time course and intensity of a drug's effect/what the drug does to the body
Pharmacokinetics What the body does to a drug
Tolerance Develops over time a need to use increased doses of a medication/drug to
maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a drug
Stevens-Johnson Syndrome A systemic, immune-mediated reaction that can be fatal or result in permanent
scarring or blindness
Antagonist A compound that blinds to a receptor that blocks or reduces the action of
another substance at the receptor site
Hyponatremia Common symptoms of this medication side effect include confusion, agitation,
and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index ratio of the median toxic dose to the median effective dose
Somnolence Daytime sleepiness
Black Box Warning This warning reflects that a medication may cause a serious or even life-
threatening side effect
Partial or Mixed Agonist A compound that elicits a partial pharmacological response at the receptor site
involved
Remission The degree of improvement to below the syndromal threshold of a disorder
Paradoxical A response to a drug that represents the clinical effect opposite of what is
expected
Inverse agonist An agent that binds to the same receptor site as an agonist but produces the
opposite pharmacological effect
4 major transmitters Dopamine, Serotonin, GABA, Norepinephrine
, Dopamine transmitter affects? affects mood, Psychosis, ADHD, Addiction
Serotonin transmitter affects? Depression, aggression, OCD, Panic, GAD, Social Anxiety, PTSD, Violence, Sexual
dysfunction, substance addiction
Norepinephrine affects? Affects mood, anxiety, psychosis, ADHD (part), drug withdrawal
GABA affects? Fear, anxiety, worry
Irreversible MAOIs Types MAOa and MAOb
Irreversible MAOIs medications Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of because they irreversibly inactivate MAOs, the therapeutic effect of a single dose
MAO for how long? of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? orthostatic hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? Moclobemide (Maerix)
How long will it take to recover MAO activity after a final MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
dose of RIMA?
