Lehne's Pharmacology for Nursing Care -
Elsevier e-Book on VitalSource, 12th
Edition
by Jacqueline Rosenjack Burchum, DNSc,
FNP-BC, CNE and Laura D. Rosenthal, DNP,
RN, ACNP-BC, FAANP
TEST BANK
UNIT I: INTRODUCTION
Chapter 1 – Orientation to Pharmacology
Lehne’s Pharmacology for Nursing Care, 12th Edition
1. Which term describes the study of what drugs do to the
body?
A. Pharmacokinetics
B. Pharmacodynamics
C. Therapeutics
D. Toxicology
,Correct Answer: B
Rationale: Pharmacodynamics examines the biochemical and
physiologic effects of drugs and their mechanisms of action.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
– Orientation to Pharmacology
2. Which process is included in pharmacokinetics?
A. Receptor binding
B. Drug–receptor affinity
C. Absorption, distribution, metabolism, and excretion
D. Therapeutic index determination
Correct Answer: C
Rationale: Pharmacokinetics describes how the body affects a
drug through absorption, distribution, metabolism, and
excretion (ADME).
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
3. A drug that produces the maximum possible response
regardless of dose is classified as a(n):
A. Partial agonist
B. Antagonist
C. Full agonist
D. Competitive inhibitor
,Correct Answer: C
Rationale: A full agonist has high intrinsic activity and can
produce maximal therapeutic effect.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
4. Which factor most directly affects the intensity of a drug’s
response?
A. Drug potency
B. Drug efficacy
C. Route of elimination
D. Drug color
Correct Answer: B
Rationale: Efficacy refers to the maximum effect a drug can
produce and determines the intensity of response.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
5. A medication with a narrow therapeutic index requires:
A. Routine discontinuation
B. Minimal monitoring
C. Careful monitoring of plasma drug levels
D. Larger loading doses
Correct Answer: C
Rationale: Drugs with a narrow therapeutic index have a small
margin between therapeutic and toxic doses, requiring close
, monitoring.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
6. Which statement best describes a drug antagonist?
A. Produces a maximal response
B. Binds to receptors and blocks activation
C. Enhances intrinsic activity
D. Increases receptor sensitivity
Correct Answer: B
Rationale: Antagonists bind to receptors but do not activate
them, thereby blocking agonist effects.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
7. A nurse administering an oral medication understands that
first-pass metabolism occurs in the:
A. Kidneys
B. Lungs
C. Liver
D. Intestines only
Correct Answer: C
Rationale: First-pass metabolism occurs primarily in the liver,
reducing the amount of active drug reaching systemic
circulation.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
Elsevier e-Book on VitalSource, 12th
Edition
by Jacqueline Rosenjack Burchum, DNSc,
FNP-BC, CNE and Laura D. Rosenthal, DNP,
RN, ACNP-BC, FAANP
TEST BANK
UNIT I: INTRODUCTION
Chapter 1 – Orientation to Pharmacology
Lehne’s Pharmacology for Nursing Care, 12th Edition
1. Which term describes the study of what drugs do to the
body?
A. Pharmacokinetics
B. Pharmacodynamics
C. Therapeutics
D. Toxicology
,Correct Answer: B
Rationale: Pharmacodynamics examines the biochemical and
physiologic effects of drugs and their mechanisms of action.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
– Orientation to Pharmacology
2. Which process is included in pharmacokinetics?
A. Receptor binding
B. Drug–receptor affinity
C. Absorption, distribution, metabolism, and excretion
D. Therapeutic index determination
Correct Answer: C
Rationale: Pharmacokinetics describes how the body affects a
drug through absorption, distribution, metabolism, and
excretion (ADME).
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
3. A drug that produces the maximum possible response
regardless of dose is classified as a(n):
A. Partial agonist
B. Antagonist
C. Full agonist
D. Competitive inhibitor
,Correct Answer: C
Rationale: A full agonist has high intrinsic activity and can
produce maximal therapeutic effect.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
4. Which factor most directly affects the intensity of a drug’s
response?
A. Drug potency
B. Drug efficacy
C. Route of elimination
D. Drug color
Correct Answer: B
Rationale: Efficacy refers to the maximum effect a drug can
produce and determines the intensity of response.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
5. A medication with a narrow therapeutic index requires:
A. Routine discontinuation
B. Minimal monitoring
C. Careful monitoring of plasma drug levels
D. Larger loading doses
Correct Answer: C
Rationale: Drugs with a narrow therapeutic index have a small
margin between therapeutic and toxic doses, requiring close
, monitoring.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
6. Which statement best describes a drug antagonist?
A. Produces a maximal response
B. Binds to receptors and blocks activation
C. Enhances intrinsic activity
D. Increases receptor sensitivity
Correct Answer: B
Rationale: Antagonists bind to receptors but do not activate
them, thereby blocking agonist effects.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
7. A nurse administering an oral medication understands that
first-pass metabolism occurs in the:
A. Kidneys
B. Lungs
C. Liver
D. Intestines only
Correct Answer: C
Rationale: First-pass metabolism occurs primarily in the liver,
reducing the amount of active drug reaching systemic
circulation.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
