PRINCIPLES OF INTERNAL MEDICINE SELF
ASSESSMENT FINAL PAPER 2026 QUESTIONS
WITH ANSWERS GRADED A+
◉ Factitious hypoglycemia. Answer: Artificially induced low blood
sugar levels, often caused by surreptitious insulin use or ingestion of
sulfonylurea drugs.
◉ Sulfonylurea drug screen. Answer: A test to detect the presence of
sulfonylurea drugs in the body, used to confirm artificially induced
hypoglycemia.
◉ Whipple triad. Answer: A set of symptoms indicating hypoglycemia,
including low plasma glucose concentration, and relief of symptoms
with increased blood glucose levels.
◉ Counterregulatory hormones. Answer: Hormones such as glucagon,
epinephrine, cortisol, and growth hormone, which help raise blood
glucose levels in response to low blood sugar (hypoglycemia).
◉ HMG-CoA reductase inhibitors. Answer: Medications that lower
cholesterol levels by inhibiting the enzyme HMG-CoA reductase,
, including various drugs such as lovastatin, pravastatin, simvastatin,
fluvastatin, atorvastatin, rosuvastatin, and pitavastatin.
◉ Cholesterol absorption inhibitor. Answer: A drug that reduces the
absorption of cholesterol in the intestine, exemplified by ezetimibe.
◉ Bile acid sequestrants. Answer: Medications that bind to bile acids in
the intestine, reducing cholesterol reabsorption, including
cholestyramine, colestipol, and colesevelam.
◉ PCSK9 inhibitors. Answer: Antibodies that bind to proprotein
convertase subtilisin/kexin type 9 (PCSK9) and reduce LDL cholesterol
levels, such as evolocumab and alirocumab.
◉ MTP inhibitor. Answer: A substance that inhibits microsomal
triglyceride transfer protein, for instance, lomitapide.
◉ ApoB inhibitor. Answer: A medication that inhibits apolipoprotein B,
for example, mipomersen.
◉ LDL-C. Answer: Low-density lipoprotein cholesterol, a type of
cholesterol linked to increased cardiovascular risk.
◉ Elevated LDL-C. Answer: High levels of low-density lipoprotein
cholesterol, associated with increased cardiovascular risk.
ASSESSMENT FINAL PAPER 2026 QUESTIONS
WITH ANSWERS GRADED A+
◉ Factitious hypoglycemia. Answer: Artificially induced low blood
sugar levels, often caused by surreptitious insulin use or ingestion of
sulfonylurea drugs.
◉ Sulfonylurea drug screen. Answer: A test to detect the presence of
sulfonylurea drugs in the body, used to confirm artificially induced
hypoglycemia.
◉ Whipple triad. Answer: A set of symptoms indicating hypoglycemia,
including low plasma glucose concentration, and relief of symptoms
with increased blood glucose levels.
◉ Counterregulatory hormones. Answer: Hormones such as glucagon,
epinephrine, cortisol, and growth hormone, which help raise blood
glucose levels in response to low blood sugar (hypoglycemia).
◉ HMG-CoA reductase inhibitors. Answer: Medications that lower
cholesterol levels by inhibiting the enzyme HMG-CoA reductase,
, including various drugs such as lovastatin, pravastatin, simvastatin,
fluvastatin, atorvastatin, rosuvastatin, and pitavastatin.
◉ Cholesterol absorption inhibitor. Answer: A drug that reduces the
absorption of cholesterol in the intestine, exemplified by ezetimibe.
◉ Bile acid sequestrants. Answer: Medications that bind to bile acids in
the intestine, reducing cholesterol reabsorption, including
cholestyramine, colestipol, and colesevelam.
◉ PCSK9 inhibitors. Answer: Antibodies that bind to proprotein
convertase subtilisin/kexin type 9 (PCSK9) and reduce LDL cholesterol
levels, such as evolocumab and alirocumab.
◉ MTP inhibitor. Answer: A substance that inhibits microsomal
triglyceride transfer protein, for instance, lomitapide.
◉ ApoB inhibitor. Answer: A medication that inhibits apolipoprotein B,
for example, mipomersen.
◉ LDL-C. Answer: Low-density lipoprotein cholesterol, a type of
cholesterol linked to increased cardiovascular risk.
◉ Elevated LDL-C. Answer: High levels of low-density lipoprotein
cholesterol, associated with increased cardiovascular risk.
