1
NR 566 Midterm Exam Study Guide
Advanced Pharmacology for Care of the
Family Questions and Answers
Chamberlain College A+ Already
Passed
Which non-amphetamines are FDA approved for weight loss that
have lower abuse risk? <<Answer>> Phentermine and
Diethylpropion
How does Phentermine and Diethylpropion promote weight loss?
<<Answer>> -Promote weight loss by decreasing appetite
-They are central nervous system (CNS) stimulants that suppress
appetite by increasing the availability of norepinephrine at
receptors in the brain
What is the maximum recommended duration of use for
non-amphetamines? <<Answer>> 3 months or less
What drug schedule are Phentermine and Diethylpropion under?
<<Answer>> Schedule IV
What labs should be monitored with Phentermine and
Diethylpropion? What condition should we screen for?
<<Answer>> -baseline CMP (watch electrolytes and creatinine)
-screen for depression
Phentermine adverse effects <<Answer>> -increase HR and BP
-dry mouth and constipation
What is role of topiramate in weight loss? <<Answer>> Increases
satiety
What are some Phentermine/topiramate contraindications for
use? <<Answer>> not approved in children and contraindicated
,2
with severe hepatic impairment
How should we educate patient to take Phentermine/topiramate
to avoid insomnia? <<Answer>> given before 1600
What are some high-risk patient conditions that we should use
Phentermine/topiramate with caution? <<Answer>> hx drug
abuse, glaucoma, pregnant, HTN, hyperthyroidism
Phentermine/topiramate adverse effects <<Answer>> insomnia,
nervousness, anxiety, depression, blurred vision
Which of the following would be a contraindication to prescribing
phentermine/topiramate? Select all that apply. <<Answer>> A)
Glaucoma
B) Hypothyroidism
C) Hypertension
D) Hyperthyroidism
E) Vitamin D Deficiency
F) A, B, E
ANSWER: A,C,D
Orlistat is a lipase inhibitor that acts on the and reduces
absorption of fat by 30%. <<Answer>> GI tract
Take multivitamin hours before/after to supplement fat-soluble
vitamins that may not be absorbed well when taking Orlistat.
<<Answer>> 2
Orlistat is OTC as 60 mg TID with meals. Not approved in
children < .
<<Answer>> 12
Orlistat results in the least amount of weight loss of all. How
much? <<Answer>> 2-3% body weight (7 lbs in year)
Orlistat adverse effects <<Answer>> Fecal incontinence, oily
rectal leakage, flatus, abdominal cramps. liver damage (light-
,3
colored stools, dark urine, fatigue, jaundice, anorexia)
When is Orlistat contraindicated? <<Answer>> In those with
malabsorption syndrome or cholestasis
What vitamin deficiency are we concerned about when taking
Orlistat...especially if the patient is on coumadin? <<Answer>>
Monitor Coumadin as Vitamin K deficiency may occur and
intensify effect of Coumadin.
A patient with a BMI of 27 would be considered: <<Answer>>
overweight
Lorcaserin adverse effects <<Answer>> headache, URI, back
pain, hypoglycemia (in DM), blood dyscrasias, cognitive
impairment, psychiatric disorders, priapism, pulmonary
hypertension, and valvular heart disease
Lorcaserin MOA <<Answer>> Reduces waist circumference,
fasting glucose, insulin, total cholesterol, LDL, triglycerides
When is Lorcaserin contraindicated? <<Answer>> CrCl <30
-Not approved in children
Lorcaserin drug interactions <<Answer>> -MAOI inhibitors,
SSRIs, SNRIs, St. Johns wart, and triptans
-Increased risk for serotonin syndrome
Naltrexone and Bupropion black box warning <<Answer>>
increased risk for suicidal ideation and suicide attempts in
children, adolescents, and young adults
Do not take Naltrexone and Bupropion within weeks of
taking a . <<Answer>> - two
-MAOI
Due to Naltrexone and Bupropion antagonist effects, it can
reduce effects of what? <<Answer>> opioids
Naltrexone and Bupropion contraindications <<Answer>> HTN,
, 4
seizure disorders, eating disorders, alcohol or drug withdrawal
Liraglutide MOA <<Answer>> -promotes weight loss by slowing
gastric emptying
-increases satiety
-Not approved children.
When taking Liraglutide, it is not unusual for baseline HR to
increase
bp
m <<Answer>> 10-20
-monitor for tachycardia
When taking Liraglutide, monitor for in patients with
diabetes <<Answer>> hypoglycemia
Baseline labs for Liraglutide <<Answer>> lipids, CMP, HgA1C q 6
months, triglycerides
Liraglutide black box warning <<Answer>> associated with a risk
for thyroid C-cell tumors based on studies in rodents
-Contraindicated in people with multiple endocrine neoplasia
syndrome type 2 (MEN 2) or personal/family history of medullary
thyroid carcinoma
Those trying to LOSE weight should exercise at least
min/week or
more <<Answer>> 150
What BMI is bariatric surgery considered? <<Answer>> 35 or
more
Common procedures:
-Gastric Bypass Surgery (Roux-en-Y procedure)
-Laparoscopic implantation of an adjustable gastric band
What is typical weight loss for those who diligently adhere to
medication and lifestyle therapy? % whereas > % is
NR 566 Midterm Exam Study Guide
Advanced Pharmacology for Care of the
Family Questions and Answers
Chamberlain College A+ Already
Passed
Which non-amphetamines are FDA approved for weight loss that
have lower abuse risk? <<Answer>> Phentermine and
Diethylpropion
How does Phentermine and Diethylpropion promote weight loss?
<<Answer>> -Promote weight loss by decreasing appetite
-They are central nervous system (CNS) stimulants that suppress
appetite by increasing the availability of norepinephrine at
receptors in the brain
What is the maximum recommended duration of use for
non-amphetamines? <<Answer>> 3 months or less
What drug schedule are Phentermine and Diethylpropion under?
<<Answer>> Schedule IV
What labs should be monitored with Phentermine and
Diethylpropion? What condition should we screen for?
<<Answer>> -baseline CMP (watch electrolytes and creatinine)
-screen for depression
Phentermine adverse effects <<Answer>> -increase HR and BP
-dry mouth and constipation
What is role of topiramate in weight loss? <<Answer>> Increases
satiety
What are some Phentermine/topiramate contraindications for
use? <<Answer>> not approved in children and contraindicated
,2
with severe hepatic impairment
How should we educate patient to take Phentermine/topiramate
to avoid insomnia? <<Answer>> given before 1600
What are some high-risk patient conditions that we should use
Phentermine/topiramate with caution? <<Answer>> hx drug
abuse, glaucoma, pregnant, HTN, hyperthyroidism
Phentermine/topiramate adverse effects <<Answer>> insomnia,
nervousness, anxiety, depression, blurred vision
Which of the following would be a contraindication to prescribing
phentermine/topiramate? Select all that apply. <<Answer>> A)
Glaucoma
B) Hypothyroidism
C) Hypertension
D) Hyperthyroidism
E) Vitamin D Deficiency
F) A, B, E
ANSWER: A,C,D
Orlistat is a lipase inhibitor that acts on the and reduces
absorption of fat by 30%. <<Answer>> GI tract
Take multivitamin hours before/after to supplement fat-soluble
vitamins that may not be absorbed well when taking Orlistat.
<<Answer>> 2
Orlistat is OTC as 60 mg TID with meals. Not approved in
children < .
<<Answer>> 12
Orlistat results in the least amount of weight loss of all. How
much? <<Answer>> 2-3% body weight (7 lbs in year)
Orlistat adverse effects <<Answer>> Fecal incontinence, oily
rectal leakage, flatus, abdominal cramps. liver damage (light-
,3
colored stools, dark urine, fatigue, jaundice, anorexia)
When is Orlistat contraindicated? <<Answer>> In those with
malabsorption syndrome or cholestasis
What vitamin deficiency are we concerned about when taking
Orlistat...especially if the patient is on coumadin? <<Answer>>
Monitor Coumadin as Vitamin K deficiency may occur and
intensify effect of Coumadin.
A patient with a BMI of 27 would be considered: <<Answer>>
overweight
Lorcaserin adverse effects <<Answer>> headache, URI, back
pain, hypoglycemia (in DM), blood dyscrasias, cognitive
impairment, psychiatric disorders, priapism, pulmonary
hypertension, and valvular heart disease
Lorcaserin MOA <<Answer>> Reduces waist circumference,
fasting glucose, insulin, total cholesterol, LDL, triglycerides
When is Lorcaserin contraindicated? <<Answer>> CrCl <30
-Not approved in children
Lorcaserin drug interactions <<Answer>> -MAOI inhibitors,
SSRIs, SNRIs, St. Johns wart, and triptans
-Increased risk for serotonin syndrome
Naltrexone and Bupropion black box warning <<Answer>>
increased risk for suicidal ideation and suicide attempts in
children, adolescents, and young adults
Do not take Naltrexone and Bupropion within weeks of
taking a . <<Answer>> - two
-MAOI
Due to Naltrexone and Bupropion antagonist effects, it can
reduce effects of what? <<Answer>> opioids
Naltrexone and Bupropion contraindications <<Answer>> HTN,
, 4
seizure disorders, eating disorders, alcohol or drug withdrawal
Liraglutide MOA <<Answer>> -promotes weight loss by slowing
gastric emptying
-increases satiety
-Not approved children.
When taking Liraglutide, it is not unusual for baseline HR to
increase
bp
m <<Answer>> 10-20
-monitor for tachycardia
When taking Liraglutide, monitor for in patients with
diabetes <<Answer>> hypoglycemia
Baseline labs for Liraglutide <<Answer>> lipids, CMP, HgA1C q 6
months, triglycerides
Liraglutide black box warning <<Answer>> associated with a risk
for thyroid C-cell tumors based on studies in rodents
-Contraindicated in people with multiple endocrine neoplasia
syndrome type 2 (MEN 2) or personal/family history of medullary
thyroid carcinoma
Those trying to LOSE weight should exercise at least
min/week or
more <<Answer>> 150
What BMI is bariatric surgery considered? <<Answer>> 35 or
more
Common procedures:
-Gastric Bypass Surgery (Roux-en-Y procedure)
-Laparoscopic implantation of an adjustable gastric band
What is typical weight loss for those who diligently adhere to
medication and lifestyle therapy? % whereas > % is
