NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS QUESTIONS AND CORRECT ANSWERS RATED A+

NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS
QUESTIONS AND CORRECT ANSWERS RATED A+

QUESTION
What is pharmacokinetics?

CORRECT ANSWER
The process by which drugs are absorbed, distributed within the body, metabolized, and
excreted.



QUESTION
What is pharmacodynamics?

CORRECT ANSWER
The study of what the drug does to the body.



QUESTION
What factors affect drug absorption?

CORRECT ANSWER
Rate of dissolution, surface area, blood flow, lipid solubility, and pH partitioning.



QUESTION
What factors affect drug distribution?

CORRECT ANSWER
Blood flow to tissues, ability to exit the vascular system, blood-brain barrier, and protein-binding
capacity.



QUESTION
What are xenobiotics?

, CORRECT ANSWER
Substances that are foreign to the body, usually synthetic chemical compounds; medications are
a common example.



QUESTION
What is Cytochrome P450 (CYP450)?

CORRECT ANSWER
Xenobiotic-metabolizing enzymes necessary for cholesterol and steroid production,
detoxification of chemicals, and drug metabolism.



QUESTION

What is the function of Cytochrome P450 (CYP450)?

CORRECT ANSWER
Responsible for phase 1 metabolism in which drugs are oxidized, reduced, or hydrolyzed.



QUESTION
What occurs during Phase 1 metabolism of drugs via P450?

CORRECT ANSWER
Oxidation, reduction, and hydrolysis.



QUESTION
What are the three possible outcomes of Phase 1 drug metabolism?

CORRECT ANSWER
The drug becomes completely inactive; the drug becomes partially inactive with one or more
active metabolites; or the original drug is inactive but an active metabolite remains.



QUESTION
What are CYP450 inducers?

CORRECT ANSWER