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15th EditionbyBertram G.Katzung,Verified
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Chapters 1 – 66 gh g h gh gh
,Table of Contents gh gh
1. Introduction: The Nature of Drugs & Drug Development & Regulation gh gh gh gh gh gh gh gh gh
2. Drug Receptors & Pharmacodynamics
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3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action gh gh gh gh gh gh gh gh gh gh gh
4. Drug Biotransformation
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5. Pharmacogenomics
6. Introduction to Autonomic Pharmacology gh gh gh
7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs gh gh gh
8. Cholinoceptor-Blocking Drugs gh
9. Adrenoceptor Agonists & Sympathomimetic Drugs gh gh gh gh
10. Adrenoceptor Antagonist Drugs gh gh
11. Antihypertensive Agents gh
12. Vasodilators & the Treatment of Angina Pectoris gh gh gh gh gh gh
13. Drugs Used in Heart Failure
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14. Agents Used in Cardiac Arrhythmias
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15. Diuretic Agents gh
16. Histamine, Serotonin, & the Ergot Alkaloids gh gh gh gh gh
17. Vasoactive Peptides gh
18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds
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19. Nitric Oxide gh
20. Drugs Used in Asthma
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21. Introduction to the Pharmacology of CNS Drugs gh gh gh gh gh gh
22. Sedative-Hypnotic Drugs gh
23. The Alcohols
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24. Antiseizure Drugs gh
25. General Anesthetics gh
26. Local Anesthetics
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27. Skeletal Muscle Relaxants gh gh
28. Pharmacologic Management of Parkinsonism & Other Movement Disorders gh gh gh gh gh gh gh
29. Antipsychotic Agents & Lithium gh gh gh
30. Antidepressant Agents gh
31. Opioid Agonists & Antagonists
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32. Drugs of Abuse gh gh
33. Agents Used in Cytopenias; Hematopoietic Growth Factors
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34. Drugs Used in Disorders of Coagulation
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35. Agents Used in Dyslipidemia
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36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid
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gAnalgesics, &
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Drugs Used in Gout
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37. Hypothalamic & Pituitary Hormones gh gh gh
38. Thyroid & Antithyroid Drugs gh gh gh
39. Adrenocorticosteroids & Adrenocortical Antagonists gh gh gh
40. The Gonadal Hormones & Inhibitors
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41. Pancreatic Hormones & Antidiabetic Drugs gh gh gh gh
42. Agents That Affect Bone Mineral Homeostasis
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43. Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics gh gh gh gh gh gh gh
,44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones
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45. Aminoglycosides & Spectinomycin gh gh
46. Sulfonamides, Trimethoprim, & Quinolones gh gh gh
47. Antimycobacterial Drugs gh
48. Antifungal Agents gh
49. Antiviral Agents gh
50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants
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51. Clinical Use of Antimicrobial Agents
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52. Antiprotozoal Drugs gh
53. Clinical Pharmacology of the Antihelminthic Drugs
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54. Cancer Chemotherapy
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55. Immunopharmacology
56. Introduction to Toxicology: Occupational & Environmental gh gh gh gh gh
57. Heavy Metal Intoxication & Chelators
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58. Management of the Poisoned Patient gh gh gh gh
59. Special Aspects of Perinatal & Pediatric Pharmacology
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60. Special Aspects of Geriatric Pharmacology
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61. Dermatologic Pharmacology gh
62. Drugs Used in the Treatment of Gastrointestinal Diseases
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63. Therapeutic & Toxic Potential of Over-the-Counter Agents
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64. Dietary Supplements & Herbal Medications
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65. Rational Prescribing & Prescription Writing
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66. Important Drug Interactions & Their Mechanisms
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1. A nurse working in radiology administers iodine to a patient who is
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ghaving a computed tomography (CT) scan. The nurse working on the
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oncology unit administers chemotherapy to patients who have cancer.
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At the Public Health Department, a nurse administers a measles-
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mumps- rubella (MMR) vaccine toa 14-month-old child as a routine g h gh gh gh gh gh gh gh gh
immunization. Which branch of pharmacology best describes the actions
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g of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
, Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses gh gh gh gh gh gh gh gh gh gh
g are involved with clinical pharmacology or pharmacotherapeutics,
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g which is a branch of pharmacology that deals with the uses of drugs
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to treat, prevent, and diagnose disease. The radiology nurse is
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gadministering a drug to help diagnose a disease. The oncology nurse
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is administering a drug to help treat adisease. Pharmacoeconomics
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includes any costs involved in drug therapy.
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Pharmacodynamics involves how a drug affects the body gh gh gh gh gh gh gh
andpharmacokinetics is how the body acts on the body.
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2. When involved in phase III drug evaluation studies, what
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gresponsibilitieswould the nurse have?
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A) Working with animals who are given experimental drugs gh gh gh gh gh gh g h
B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects gh gh gh gh gh gh g h
D) Conducting research to determine effectiveness of the drug gh gh gh gh gh gh g h
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in
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gwhichpatients are asked to record any symptoms they experience
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g while taking thedrugs. Nurses may be responsible for helping collect
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gand analyze the information to be shared with the Food and Drug
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Administration (FDA) butwould not conduct research independently
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gbecause nurses do not prescribe medications. Use of animals in drug
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gtesting is done in the preclinical trials. Select patients who are
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involved in phase II studies to participate in studies where the
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participants have the disease the drug is intended to treat. These
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patients are monitored closely for drug action and adverse effects.
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Phase I studies involve healthy human volunteers who are usually
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paid for their participation. Nurses may observe for adverse effects
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and toxicity.
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