Alteplase (tPA)
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Fibrinolytic therapy also known as tissue plasminogen activator (tPA). Must
be given within 3 to 4.5 hours of the initial symptoms
Paresis
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Muscular weakness
Parasthesia
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Tingling or prickling sensation, often in arms, hands, legs or feet
Thrombotic CVA
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Occlusion of a vessel by a thrombus. Most common > age 50, during sleep
TIA S/S
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Temporary vision loss, transient hemiparesis, vertigo & confusion, typically
last less than 1 hour
Diagnostics
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Neuro exam, CT scan (Initially for hemorrhage), MRI, MR Angiography, Intr-
Arterial Digital Subtraction Angiography (DSA), Transcranial Doppler (TCD),
Ultrasonography, Lumbar puncture, LICOX Monitoring, Cerebral
Arteriography (Patency of vessels)
, Patho of a hemorrhagic stroke
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Emboli lodges in vessels and weaken it causing the vessel to rupture. Blood
enters the brain tissue, cerebral ventricles, and subarachnoid space,
compressing adjacent tissue and causing blood spasms and cerebral
edema
Meds-Acute Stroke
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To prevent further thrombosis formation, increase blood flow
-Anticoagulant (coumadin-PT/INR), heparin-PTT, warfarin)
-Fibrinolytic (tPA-protein involved in the breakdown of clots)
-Antithromotics (ASA, plavix)
-Corticosteroids (prednisone)
-Anticonvulsants (dilantin, phenytoin, lamotrigine, topamax)
-Diuretics-CVA w/ ^ICP(lasix, aldactone)
Modifiable Risk Factors
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Smoking, HTN, Heart Disease, ^Cholesterol, Excessive alcohol and drug
use, obesity, lack of exercise, Sleep apnea, DM, Poor Diet
Give this one a try later!
Fibrinolytic therapy also known as tissue plasminogen activator (tPA). Must
be given within 3 to 4.5 hours of the initial symptoms
Paresis
Give this one a try later!
Muscular weakness
Parasthesia
,Give this one a try later!
Tingling or prickling sensation, often in arms, hands, legs or feet
Thrombotic CVA
Give this one a try later!
Occlusion of a vessel by a thrombus. Most common > age 50, during sleep
TIA S/S
Give this one a try later!
Temporary vision loss, transient hemiparesis, vertigo & confusion, typically
last less than 1 hour
Diagnostics
Give this one a try later!
Neuro exam, CT scan (Initially for hemorrhage), MRI, MR Angiography, Intr-
Arterial Digital Subtraction Angiography (DSA), Transcranial Doppler (TCD),
Ultrasonography, Lumbar puncture, LICOX Monitoring, Cerebral
Arteriography (Patency of vessels)
, Patho of a hemorrhagic stroke
Give this one a try later!
Emboli lodges in vessels and weaken it causing the vessel to rupture. Blood
enters the brain tissue, cerebral ventricles, and subarachnoid space,
compressing adjacent tissue and causing blood spasms and cerebral
edema
Meds-Acute Stroke
Give this one a try later!
To prevent further thrombosis formation, increase blood flow
-Anticoagulant (coumadin-PT/INR), heparin-PTT, warfarin)
-Fibrinolytic (tPA-protein involved in the breakdown of clots)
-Antithromotics (ASA, plavix)
-Corticosteroids (prednisone)
-Anticonvulsants (dilantin, phenytoin, lamotrigine, topamax)
-Diuretics-CVA w/ ^ICP(lasix, aldactone)
Modifiable Risk Factors
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Smoking, HTN, Heart Disease, ^Cholesterol, Excessive alcohol and drug
use, obesity, lack of exercise, Sleep apnea, DM, Poor Diet
