Test Bank for Pharmacotherapeutics for Advanced Practice Nurse Prescribers, 6th Ed.
By Teri Moser Woo and Wendy L. Wright.
All Chapters | 100% Verified Answers with Detailed Rationales | Latest AACN/NONPF, NCLEX-Aligned Edition
,I. THE FOUNDATION
1. The Role of the Nurse Practitioner as Prescriber
2. Review of the Basic Principles of Pharmacology
3. Rational Drug Selection
4. Legal and Professional Issues in Prescribing
5. Adverse Drug Reactions
6. An Introduction to Pharmacogenetics
7. Nutrition and Neutraceuticals
8. Herbal Therapies
9. Cannabis
10. Pharmacoeconomics
II. PHARMACOTHERAPEUTICS WITH SINGLE DRUGS
11. Drugs Affecting the Autonomic Nervous System
12. Drugs Affecting the Central Nervous System
13. Drugs Affecting the Cardiovascular and Renal Systems
14. Drugs Affecting the Respiratory System
15. Drugs Affecting the Hematological System
16. Drugs Affecting the Immune System: Immunizations
17. Drugs Affecting the Immune System: Immunomodulators
18. Drugs Affecting the Gastrointestinal System
19. Drugs Affecting the Endocrine System: Pancreatic Hormones and Antidiabetic Drugs
20. Drugs Affecting the Endocrine System: Pituitary, Thyroid, and Adrenal Drugs
21. Drugs Affecting the Reproductive System
22. Drugs Affecting the Bones and Joints
23. Drugs Affecting the Integumentary System
24. Drugs Used to Treat Bacterial Infections
25. Drugs Used to Treat Viral, Fungal, and Protozoal Infections
26. Drugs Used to Treat Inflammatory Processes
27. Drugs Used to Treat Eye and Ear Disorders
III. PHARMACOTHERAPEUTICS WITH MULTIPLE DRUGS
28. Anemia
29. Anxiety and Depression
30. Attention Deficit Hyperactivity Disorder
31. Asthma and Allergy
32. Chronic Obstructive Pulmonary Disease
33. Contraception
34. COVID-19: Acute and Chronic
35. Dermatological Conditions
36. Diabetes Management
37. Gastroesophageal Reflux and Peptic Ulcer Disease
38. Headaches
39. Heart Failure
40. Human Immunodeficiency Virus Disease and Acquired Immunodeficiency Syndrome
41. Menopausal Hormone Therapy
42. Hyperlipidemia
43. Hypertension
44. Hyperthyroidism and Hypothyroidism
45. Obesity
46. Pain Management: Acute and Chronic Pain
47. Pneumonia
48. Sexually Transmitted Diseases and Vaginitis
49. Substance Use Disorder
50. Tuberculosis
51. Upper Respiratory Infection, Pharyngitis, Sinusitis, Otitis Media, and Otitis Externa
52. Urinary Tract Infection
IV. SPECIAL DRUG TREATMENT CONSIDERATIONS
53. Women as Patients
54. Men as Patients
55. Pediatric Patients
56. Transgender Persons as Patients
57. Geriatric Patients
,Chapter 1. The Role of the Advanced Practice Nurse as Prescriber
MULTIPLE CHOICE
1. Nurse practitioner prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing for each state
D. The State Board of Pharmacy
Answer: C PTS: 1
2. The benefits to the patient of having an advanced practice registered nurse (APRN) prescriber include:
A. Nurses know more about pharmacology than other prescribers because they take it both in their basic
nursing program and in their APRN program.
B. Nurses care for the patient from a holistic approach and include the patient in decision-making
regarding their care.
C. APRNs are less likely to prescribe narcotics and other controlled substances.
D. APRNs are able to prescribe independently in all states, whereas a physician’s assistant needs to have a
physician supervising their practice.
Answer: B PTS: 1
3. Clinical judgment in prescribing includes:
A. Factoring in the cost to the patient of the medication prescribed
B. Always prescribing the newest medication available for the disease process
C. Handing out drug samples to poor patients
D. Prescribing all generic medications to cut costs
Answer: A PTS: 1
,4. The process for choosing an effective drug for a disorder includes:
A. Asking the patient what drug they think would work best for them
B. Consulting nationally recognized guidelines for disease management
C. Prescribing medications that are available as samples before writing a prescription
D. Following U.S. Drug Enforcement Administration guidelines for prescribing
Answer: B PTS: 1
5. Nonintentional non adherence of drug therapy may occur due to:
A. Belief that medication does not work
B. Adverse drug reactions
C. Chronic conditions that require daily therapy
D. Forgetfulness or distraction
Answer: D PTS: 1
,Chapter 2. Review of Basic Principles of Pharmacology MULTIPLE CHOICE
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
A. Distribution of drugs to target tissue may be affected.
B. The solubility of the drug will not match the site of absorption.
C. There will be less free drug available to generate an effect.
D. Drugs bound to albumin are readily excreted by the kidneys.
Answer: A PTS: 1
2. Drugs that have a significant first-pass effect:
A. Must be given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little, if any, desired action
D. Are converted by the liver to more active and fat-soluble forms
Answer: C PTS: 1
3. The route of excretion of a volatile drug will likely be the:
A. Kidneys
B. Lungs
C. Bile and feces
D. Skin
Answer: B PTS: 1
,4. A major disadvantage to IV administration is that:
A. First-pass metabolism is eliminated.
B. Needles and sterility are required.
C. Absorption of the drug cannot be slowed after administration.
D. It is significantly more expensive than other routes.
Answer: C PTS: 1
5. The nurse practitioner (NP) chooses to give cephalexin every 8 hours based on knowledge of the
drug’s:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
Answer: B PTS: 1
6. Deferasirox is a chelating agent used to treat iron overload by binding iron to render it biologically
inactive. This is best characterized as a(n):
A. Nonreceptor mechanism
B. Partial agonist
C. Full agonist
D. Noncompetitive antagonist
Answer: A PTS: 1
,7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is
the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
Answer: C PTS: 1
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
A. When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor sites
D. To determine if a drug is in the therapeutic range
Answer: D PTS: 1
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
A. Concentration will produce therapeutic effects.
B. Concentration will produce an adverse response.
C. Time between doses must be shortened.
D. Duration of action of the drug is too long.
Answer: B PTS: 1
10. Drugs that are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
,C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
Answer: C PTS: 1
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
Answer: B PTS: 1
12. Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
Answer: C PTS: 1
13. Drugs administered via IV:
A. Need to be lipid soluble in order to be easily absorbed
B. Begin distribution into the body immediately
C. Are easily absorbed if they are nonionized
D. May use pinocytosis to be absorbed
Answer: B PTS: 1
,14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
A. The sum of the effects of each drug individually
B. Greater than the sum of the effects of each drug individually
C. Less than the effect of each drug individually
D. Not predictable, as it varies with each individual
Answer: B PTS: 1
15. Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained-
release mechanisms.
B. All brands of a drug have the same bioavailability.
C. Drugs that are administered more than once a day have greater bioavailability than drugs given once
daily.
D. Combining an active drug with an inert substance does not affect bioavailability.
Answer: A PTS: 1
16. Which of the following statements about the major distribution barriers (blood–brain or fetal–
placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood–brain barrier slows the passage of many drugs into and out of brain cells.
C. The fetal–placental barrier protects the fetus from drugs taken by the mother.
D. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women.
Answer: B PTS: 1
, 17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of
these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion
Answer: C PTS: 1
18. Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally “deactivated” so they are excreted without any effect
D. All of the above
Answer: D PTS: 1
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to
excrete drugs via the renal system would be increased by:
A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site from another drug
D. Increased renal blood flow
Answer: D PTS: 1
20. Steady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the peak and trough remain constant
C. When the amount of drug in the body stays below the minimum toxic concentration
By Teri Moser Woo and Wendy L. Wright.
All Chapters | 100% Verified Answers with Detailed Rationales | Latest AACN/NONPF, NCLEX-Aligned Edition
,I. THE FOUNDATION
1. The Role of the Nurse Practitioner as Prescriber
2. Review of the Basic Principles of Pharmacology
3. Rational Drug Selection
4. Legal and Professional Issues in Prescribing
5. Adverse Drug Reactions
6. An Introduction to Pharmacogenetics
7. Nutrition and Neutraceuticals
8. Herbal Therapies
9. Cannabis
10. Pharmacoeconomics
II. PHARMACOTHERAPEUTICS WITH SINGLE DRUGS
11. Drugs Affecting the Autonomic Nervous System
12. Drugs Affecting the Central Nervous System
13. Drugs Affecting the Cardiovascular and Renal Systems
14. Drugs Affecting the Respiratory System
15. Drugs Affecting the Hematological System
16. Drugs Affecting the Immune System: Immunizations
17. Drugs Affecting the Immune System: Immunomodulators
18. Drugs Affecting the Gastrointestinal System
19. Drugs Affecting the Endocrine System: Pancreatic Hormones and Antidiabetic Drugs
20. Drugs Affecting the Endocrine System: Pituitary, Thyroid, and Adrenal Drugs
21. Drugs Affecting the Reproductive System
22. Drugs Affecting the Bones and Joints
23. Drugs Affecting the Integumentary System
24. Drugs Used to Treat Bacterial Infections
25. Drugs Used to Treat Viral, Fungal, and Protozoal Infections
26. Drugs Used to Treat Inflammatory Processes
27. Drugs Used to Treat Eye and Ear Disorders
III. PHARMACOTHERAPEUTICS WITH MULTIPLE DRUGS
28. Anemia
29. Anxiety and Depression
30. Attention Deficit Hyperactivity Disorder
31. Asthma and Allergy
32. Chronic Obstructive Pulmonary Disease
33. Contraception
34. COVID-19: Acute and Chronic
35. Dermatological Conditions
36. Diabetes Management
37. Gastroesophageal Reflux and Peptic Ulcer Disease
38. Headaches
39. Heart Failure
40. Human Immunodeficiency Virus Disease and Acquired Immunodeficiency Syndrome
41. Menopausal Hormone Therapy
42. Hyperlipidemia
43. Hypertension
44. Hyperthyroidism and Hypothyroidism
45. Obesity
46. Pain Management: Acute and Chronic Pain
47. Pneumonia
48. Sexually Transmitted Diseases and Vaginitis
49. Substance Use Disorder
50. Tuberculosis
51. Upper Respiratory Infection, Pharyngitis, Sinusitis, Otitis Media, and Otitis Externa
52. Urinary Tract Infection
IV. SPECIAL DRUG TREATMENT CONSIDERATIONS
53. Women as Patients
54. Men as Patients
55. Pediatric Patients
56. Transgender Persons as Patients
57. Geriatric Patients
,Chapter 1. The Role of the Advanced Practice Nurse as Prescriber
MULTIPLE CHOICE
1. Nurse practitioner prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing for each state
D. The State Board of Pharmacy
Answer: C PTS: 1
2. The benefits to the patient of having an advanced practice registered nurse (APRN) prescriber include:
A. Nurses know more about pharmacology than other prescribers because they take it both in their basic
nursing program and in their APRN program.
B. Nurses care for the patient from a holistic approach and include the patient in decision-making
regarding their care.
C. APRNs are less likely to prescribe narcotics and other controlled substances.
D. APRNs are able to prescribe independently in all states, whereas a physician’s assistant needs to have a
physician supervising their practice.
Answer: B PTS: 1
3. Clinical judgment in prescribing includes:
A. Factoring in the cost to the patient of the medication prescribed
B. Always prescribing the newest medication available for the disease process
C. Handing out drug samples to poor patients
D. Prescribing all generic medications to cut costs
Answer: A PTS: 1
,4. The process for choosing an effective drug for a disorder includes:
A. Asking the patient what drug they think would work best for them
B. Consulting nationally recognized guidelines for disease management
C. Prescribing medications that are available as samples before writing a prescription
D. Following U.S. Drug Enforcement Administration guidelines for prescribing
Answer: B PTS: 1
5. Nonintentional non adherence of drug therapy may occur due to:
A. Belief that medication does not work
B. Adverse drug reactions
C. Chronic conditions that require daily therapy
D. Forgetfulness or distraction
Answer: D PTS: 1
,Chapter 2. Review of Basic Principles of Pharmacology MULTIPLE CHOICE
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
A. Distribution of drugs to target tissue may be affected.
B. The solubility of the drug will not match the site of absorption.
C. There will be less free drug available to generate an effect.
D. Drugs bound to albumin are readily excreted by the kidneys.
Answer: A PTS: 1
2. Drugs that have a significant first-pass effect:
A. Must be given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little, if any, desired action
D. Are converted by the liver to more active and fat-soluble forms
Answer: C PTS: 1
3. The route of excretion of a volatile drug will likely be the:
A. Kidneys
B. Lungs
C. Bile and feces
D. Skin
Answer: B PTS: 1
,4. A major disadvantage to IV administration is that:
A. First-pass metabolism is eliminated.
B. Needles and sterility are required.
C. Absorption of the drug cannot be slowed after administration.
D. It is significantly more expensive than other routes.
Answer: C PTS: 1
5. The nurse practitioner (NP) chooses to give cephalexin every 8 hours based on knowledge of the
drug’s:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
Answer: B PTS: 1
6. Deferasirox is a chelating agent used to treat iron overload by binding iron to render it biologically
inactive. This is best characterized as a(n):
A. Nonreceptor mechanism
B. Partial agonist
C. Full agonist
D. Noncompetitive antagonist
Answer: A PTS: 1
,7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is
the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
Answer: C PTS: 1
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
A. When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor sites
D. To determine if a drug is in the therapeutic range
Answer: D PTS: 1
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
A. Concentration will produce therapeutic effects.
B. Concentration will produce an adverse response.
C. Time between doses must be shortened.
D. Duration of action of the drug is too long.
Answer: B PTS: 1
10. Drugs that are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
,C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
Answer: C PTS: 1
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
Answer: B PTS: 1
12. Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
Answer: C PTS: 1
13. Drugs administered via IV:
A. Need to be lipid soluble in order to be easily absorbed
B. Begin distribution into the body immediately
C. Are easily absorbed if they are nonionized
D. May use pinocytosis to be absorbed
Answer: B PTS: 1
,14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
A. The sum of the effects of each drug individually
B. Greater than the sum of the effects of each drug individually
C. Less than the effect of each drug individually
D. Not predictable, as it varies with each individual
Answer: B PTS: 1
15. Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained-
release mechanisms.
B. All brands of a drug have the same bioavailability.
C. Drugs that are administered more than once a day have greater bioavailability than drugs given once
daily.
D. Combining an active drug with an inert substance does not affect bioavailability.
Answer: A PTS: 1
16. Which of the following statements about the major distribution barriers (blood–brain or fetal–
placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood–brain barrier slows the passage of many drugs into and out of brain cells.
C. The fetal–placental barrier protects the fetus from drugs taken by the mother.
D. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women.
Answer: B PTS: 1
, 17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of
these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion
Answer: C PTS: 1
18. Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally “deactivated” so they are excreted without any effect
D. All of the above
Answer: D PTS: 1
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to
excrete drugs via the renal system would be increased by:
A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site from another drug
D. Increased renal blood flow
Answer: D PTS: 1
20. Steady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the peak and trough remain constant
C. When the amount of drug in the body stays below the minimum toxic concentration
