HUETHER AND MCCANCE'S UNDERSTANDING PATHOPHYSIOLOGY, CANADIAN EDITION BY
KELLY POWER-KEAN RN, BN, MHS, NP, STEPHANIE ZETTEL BN, B.SC, MN, MOHAMED TOUFIC
EL-HUSSEIN RN, PHD, NP, SUE E. HUETHER MS, PHD, KATHRYN L. MCCANCE MS, PHD (2022)
||CURRENT EDITION
2nd Edition
,Table of Contents
PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGY .............................................................. 5
Unit 1: The Cell .................................................................................... 5
Chapter 01: Cellular Biology........................................................................................................ 5
Chapter 02: Genes and Genetic Diseases ................................................................................. 19
Chapter 03: Epigenetics and Disease ........................................................................................ 34
Chapter 04: Altered Cellular and Tissue Biology ....................................................................... 40
Chapter 05: Fluids and Electrolytes, Acids and Bases ............................................................... 58
Unit 2: Mechanisms of Self-Defense ............................................................................................. 72
Chapter 06: Innate Immunity: Inflammation and Wound Healing ........................................... 72
Chapter 07: Adaptive Immunity ................................................................................................ 90
Chapter 08: Infection and Defects in Mechanisms of Defence............................................... 100
Chapter 09: Stress and Disease ............................................................................................... 116
Unit 3: Cellular Proliferation: Cancer ............................................. 123
Chapter 10: Biology of Cancer ................................................................................................ 123
Chapter 11: Cancer Epidemiology........................................................................................... 133
Chapter 12: Cancer in Children and Adolescents ................................................................... 139
PART TWO: BODY SYSTEMS AND DISEASES ................................................................................ 144
Unit 4: The Neurologic System ....................................................... 144
Chapter 13: Structure and Function of the Neurological System ........................................... 144
Chapter 14: Pain, Temperature, Sleep, and Sensory Function ............................................... 161
Chapter 15: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
................................................................................................................................................. 179
Chapter 16: Disorders of the Central and Peripheral Nervous Systems and Neuromuscular
Junction ................................................................................................................................... 195
Chapter 17: Developmental Alterations of Neurological Function ......................................... 213
Unit 5: The Endocrine System ........................................................ 225
Chapter 18: Mechanisms of Hormonal Regulation ................................................................. 225
Chapter 19: Alterations of Hormonal Regulation ................................................................... 239
, Unit 6: The Hematologic System .................................................... 259
Chapter 20: Structure and Function of the Hematological System ........................................ 259
Chapter 21: Alterations of Hematological Function ............................................................... 270
Chapter 22: Developmental Alterations of Hematological Function ...................................... 295
Unit 7: The Cardiovascular and Lymphatic Systems ..................... 307
Chapter 23: Structure and Function of the Cardiovascular and Lymphatic Systems .............. 307
Chapter 24: Alterations of Cardiovascular Function ............................................................... 324
Chapter 25: Developmental Alterations of Cardiovascular Function ..................................... 354
Unit 8: The Pulmonary System ....................................................... 364
Chapter 26: Structure and Function of the Pulmonary System .............................................. 364
Chapter 27: Alterations of Pulmonary Function ..................................................................... 377
Chapter 28: Developmental Alterations of Pulmonary Function............................................ 397
Unit 9: The Renal and Urologic Systems ....................................... 408
Chapter 29: Structure and Function of the Renal and Urological Systems ............................. 408
Chapter 30: Alterations of Renal and Urinary Tract Function ................................................. 420
Chapter 31: Developmental Alterations of Renal and Urinary Tract Function ....................... 431
Unit 10: The Reproductive Systems ............................................... 440
Chapter 32: Structure and Function of the Reproductive Systems ........................................ 440
Chapter 33: Alterations of the Female Reproductive System ................................................. 454
Chapter 34: Alterations of the Male Reproductive System .................................................... 462
Unit 11: The Digestive System ....................................................... 469
Chapter 35: Structure and Function of the Digestive System ................................................. 469
Chapter 36: Alterations of Digestive Function ........................................................................ 481
Chapter 37: Developmental Alterations of Digestive Function .............................................. 501
Unit 12: The Musculoskeletal and Integumentary Systems ......... 513
Chapter 38: Structure and Function of the Musculoskeletal System ..................................... 513
Chapter 39: Alterations of Musculoskeletal Function............................................................. 526
Chapter 40: Developmental Alterations of Musculoskeletal Function ................................... 541
, Chapter 41: Structure, Function, and Disorders of the Integument ....................................... 549
Chapter 42: Alterations of the Integument in Children .......................................................... 564
Chapter 43. Co-morbidity and Multi-morbidities ................................................................... 572