APHON PRINCIPLES OF CHEMO AND
BIOTHERAPY EXAMINATION TEST 2026
QUESTIONS WITH SOLUTIONS GRADED A+
◉ immune surveillance. Answer: tumor cells express abnormal tumor
antigens on surface that can be recognized/destroyed by immune system
◉ natural killer cells. Answer: lymphocyte that recognizes/kills
malignant cells
◉ cytotoxic t cells. Answer: recognize tumor-assosiated antigens and
kills cells
◉ interferons. Answer: multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by
interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent
immunomodulatory effects
◉ cytokines. Answer: products of immune cells to enhance cytotoxic
activity of cells and increase immune response
, ◉ alpha-interferon. Answer: leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple
myeloma, cutaneous t-cell lymphoma
◉ beta-interferon. Answer: fibroblast-derived. tx MS
◉ gamma-interferon. Answer: t-lymphocyte derived. tx chronic
granulomatus disease
◉ interleukin-2. Answer: produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of
lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
◉ retinoids. Answer: immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
◉ all-trans retinoic acid (atra). Answer: tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of
coagulopathy r/t tx.
◉ isotretinoin (accutane). Answer: retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt
must register iPledge (fetal exposure). can also affect hearing & vision
BIOTHERAPY EXAMINATION TEST 2026
QUESTIONS WITH SOLUTIONS GRADED A+
◉ immune surveillance. Answer: tumor cells express abnormal tumor
antigens on surface that can be recognized/destroyed by immune system
◉ natural killer cells. Answer: lymphocyte that recognizes/kills
malignant cells
◉ cytotoxic t cells. Answer: recognize tumor-assosiated antigens and
kills cells
◉ interferons. Answer: multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by
interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative, potent
immunomodulatory effects
◉ cytokines. Answer: products of immune cells to enhance cytotoxic
activity of cells and increase immune response
, ◉ alpha-interferon. Answer: leukocyte-derived. tx: hairy cell leukemia,
melanoma, chronic myeloid leukemia, follicular lymphoma, multiple
myeloma, cutaneous t-cell lymphoma
◉ beta-interferon. Answer: fibroblast-derived. tx MS
◉ gamma-interferon. Answer: t-lymphocyte derived. tx chronic
granulomatus disease
◉ interleukin-2. Answer: produced by t-helper cells & stimulate
growth/maturation of t-cell subsets, cytotoxic t-cells, production of
lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
◉ retinoids. Answer: immunomodulators that facilitate differentiation &
suppress proliferation of cancer cells
◉ all-trans retinoic acid (atra). Answer: tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of
coagulopathy r/t tx.
◉ isotretinoin (accutane). Answer: retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt
must register iPledge (fetal exposure). can also affect hearing & vision
