NBME CBSE ACTUAL TEST QUESTIONS AND ANSWERS
2025/2026 (Quiz bank with all the correct answers)
(usmle step 1)Medical examination
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following?
Correct Answer: Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion
about the effect of exercise on the risk of hip fracture?
Correct Answer: Statistically Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of action?
Correct Answer: Increased nitric oxide concentration
62 year old man –abdominal pain – interviewed by physician – used single word and sarcastic
answers. No eye contact – FROWNS - tells physician third time he has been asked question-
Correct Answer: Appropriate response?
You Sound Upset. Tell me a little more about that.
54-year-old – ECG shows P wave and R wave no relation between the two. Which is the most
likely diagnosis?
Correct Answer: Third Degree AV Block
,42 year old – constipation, abdominal discomfort, mild fatigue, CA increased, P04 decreased,
treated for renal calculus – PE shows now abnormalities – Most likely cause of patients
condition is a small well defined nodule in which location?
Correct Answer: Parathyroid Gland
72 year old – ER – stroke symptoms – slurred speech and difficulty walking – left sided
hemiparesis – Tongue deviates to right when protruded – proprioception and sensation to light
touch are absent over the left upper and lower extremity – Which site in brain stem is damaged
Correct Answer: Area Labeled C
24 year old woman – spilled hot grease on her left leg while working at a fast-food restaurant.
Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was
most likely caused by increased activity of which?
Correct Answer: Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture – increased
serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin’s effect is due to the activation of which of the following?
Correct Answer: Adenylyl Cyclase
,Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest exam
shows intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The
infectious agent most likely has which of the following properties?
Correct Answer: Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but no
difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this
patient?
Correct Answer: B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of
fatigue. He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy
and pharyngeal erythema with a creamy exudate. DX?
Correct Answer: Infectious Mononucleosis
57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite therapy,
tumor increases in size and he dies 6 months later. The progressive tumor growth is due to a
defect in cell cycle arrest in which of the following phases of cell cycle?
Correct Answer: G1
, 28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX?
Correct Answer: Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two
gene deletion. If the two gene is trans – what percentage of offspring will have a two gene
deletion?
Correct Answer: 50%
previously healthy 40 year brought to emergency department by her husband – 2 day history of
fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower
extremities – 3+ polychromasia and 3+ schistocytes and Low platelets Dx?
Correct Answer: Thrombotic Thrombocytopenia Purpura
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest. An
X-ray of the chest shows an air-fluid level in the left side of the chest, partial collapse of the left
lung, and the elevation of the stomach bubble. The mediastinum is midline. DX?
Correct Answer: Hemopneumpothorax under tension
2025/2026 (Quiz bank with all the correct answers)
(usmle step 1)Medical examination
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following?
Correct Answer: Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion
about the effect of exercise on the risk of hip fracture?
Correct Answer: Statistically Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of action?
Correct Answer: Increased nitric oxide concentration
62 year old man –abdominal pain – interviewed by physician – used single word and sarcastic
answers. No eye contact – FROWNS - tells physician third time he has been asked question-
Correct Answer: Appropriate response?
You Sound Upset. Tell me a little more about that.
54-year-old – ECG shows P wave and R wave no relation between the two. Which is the most
likely diagnosis?
Correct Answer: Third Degree AV Block
,42 year old – constipation, abdominal discomfort, mild fatigue, CA increased, P04 decreased,
treated for renal calculus – PE shows now abnormalities – Most likely cause of patients
condition is a small well defined nodule in which location?
Correct Answer: Parathyroid Gland
72 year old – ER – stroke symptoms – slurred speech and difficulty walking – left sided
hemiparesis – Tongue deviates to right when protruded – proprioception and sensation to light
touch are absent over the left upper and lower extremity – Which site in brain stem is damaged
Correct Answer: Area Labeled C
24 year old woman – spilled hot grease on her left leg while working at a fast-food restaurant.
Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was
most likely caused by increased activity of which?
Correct Answer: Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture – increased
serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin’s effect is due to the activation of which of the following?
Correct Answer: Adenylyl Cyclase
,Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest exam
shows intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The
infectious agent most likely has which of the following properties?
Correct Answer: Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but no
difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this
patient?
Correct Answer: B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of
fatigue. He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy
and pharyngeal erythema with a creamy exudate. DX?
Correct Answer: Infectious Mononucleosis
57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite therapy,
tumor increases in size and he dies 6 months later. The progressive tumor growth is due to a
defect in cell cycle arrest in which of the following phases of cell cycle?
Correct Answer: G1
, 28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX?
Correct Answer: Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two
gene deletion. If the two gene is trans – what percentage of offspring will have a two gene
deletion?
Correct Answer: 50%
previously healthy 40 year brought to emergency department by her husband – 2 day history of
fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower
extremities – 3+ polychromasia and 3+ schistocytes and Low platelets Dx?
Correct Answer: Thrombotic Thrombocytopenia Purpura
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest. An
X-ray of the chest shows an air-fluid level in the left side of the chest, partial collapse of the left
lung, and the elevation of the stomach bubble. The mediastinum is midline. DX?
Correct Answer: Hemopneumpothorax under tension
