1
860 Mitochondria drug safety
Questions and Answers (100%
Correct Answers) Already Graded A+
mitochondria Ans: Evolved from Gram(-)
© 2026 Assignment
- Energy factory in eukaryotic cells
Guru01 - Stuvia
Structure (organelle) w/:
Expert
- Outer membrane w/ porins
- Intermembrane space
- Inner membrane (Electron transport chain)
- Matrix
Aerobic respiration Ans: citric acid cycle in mitochondrial
matrix to create/store energy
energy production (ATP) Ans: - NADH from citric acid cycle
(matrix)
-- Donates electrons to ETC
- Movement of electrons generates H ions from H20
- electrons received by molecular oxygen
, 2
- Membrane potential difference used to make ATP which is
exported across inner membrane
cell generates energy and stores it as ATP
Electron transport chain (ETC) Ans: creates reactive oxygen
species (superoxide, peroxide, hydroxyl)
- Small amount: cell signalling
© 2026 Assignment
- Mod amount: inflammation and immune response
Guru01 - Stuvia
-Large amount: cell injury and death
Expert
mitochondria characteristics Ans: - Divide (fission)
- Fuse (merge w/ other mitochondria)
- Extensive processes to repair structure and proteins
- Damaged or malfunctioning mitochondria can wreak havoc in
the cell
- Mitophagy (destruction of mitochondria)
Linezolid Mitotoxicity Ans: - inhibits mitochondrial protein
synthesis by binding ribosomes.
-Variations in the mtDNA (SNP’s) may affect individual
sensitivity to toxicity
• mitochondrial DNA polymorphism A2706G (lactic acidosis)
Can lead to:
860 Mitochondria drug safety
Questions and Answers (100%
Correct Answers) Already Graded A+
mitochondria Ans: Evolved from Gram(-)
© 2026 Assignment
- Energy factory in eukaryotic cells
Guru01 - Stuvia
Structure (organelle) w/:
Expert
- Outer membrane w/ porins
- Intermembrane space
- Inner membrane (Electron transport chain)
- Matrix
Aerobic respiration Ans: citric acid cycle in mitochondrial
matrix to create/store energy
energy production (ATP) Ans: - NADH from citric acid cycle
(matrix)
-- Donates electrons to ETC
- Movement of electrons generates H ions from H20
- electrons received by molecular oxygen
, 2
- Membrane potential difference used to make ATP which is
exported across inner membrane
cell generates energy and stores it as ATP
Electron transport chain (ETC) Ans: creates reactive oxygen
species (superoxide, peroxide, hydroxyl)
- Small amount: cell signalling
© 2026 Assignment
- Mod amount: inflammation and immune response
Guru01 - Stuvia
-Large amount: cell injury and death
Expert
mitochondria characteristics Ans: - Divide (fission)
- Fuse (merge w/ other mitochondria)
- Extensive processes to repair structure and proteins
- Damaged or malfunctioning mitochondria can wreak havoc in
the cell
- Mitophagy (destruction of mitochondria)
Linezolid Mitotoxicity Ans: - inhibits mitochondrial protein
synthesis by binding ribosomes.
-Variations in the mtDNA (SNP’s) may affect individual
sensitivity to toxicity
• mitochondrial DNA polymorphism A2706G (lactic acidosis)
Can lead to:
