GMS 6504 LATEST 2026 EXAM QUESTIONS AND ANSWERS
SCORED A+
✔✔after addition of an agonist, you measure an increase in mRNA from the
whatchamacallit gene. this is an example of a group ___ assay.
•1
•2
•3 - ✔✔3
✔✔you have cells that express fluorescent beta-arrestin. upon addition of an agonist
that binds to GPCRs, would you expect fluorescence located at the cell membrane to
increase or decrease after giving time for the system to equilibrate?
•increase
•decrease - ✔✔decrease
✔✔an antagonist that has a concentration where addition of more antagonist will have
no additional measurable effect is called...
•saturable
•unsaturable
•surmountable
•unsurmountable - ✔✔saturable
✔✔a more potent antagonist will have a ___ pA2.
•higher
•lower - ✔✔lower
✔✔a schind analysis reveals a graph that resembles a y=x^2 graph. this antagonist is
most likely...
•noncompetitive
•competitive
•cooperative
•interacting with heterogenous receptors
•not at equilibrium - ✔✔noncompetitive
✔✔a reversible inverse agonist applied to a system that does not contain activity will
appear to behave most like a[n] ___ antagonist.
•noncompetitive
•competitive
, •allosteric - ✔✔competitive
✔✔it is possible for a competitive antagonist and an allosteric modulator to have
synergistic effects in blocking agonist binding.
•true
•false - ✔✔true
✔✔an allosteric modulator with alpha>1, beta=1 is best classified as a...
•NAM
•PAM
•PAM-antagonist - ✔✔PAM
✔✔an allosteric modulator that increases affinity while decreasing efficacy is best
classified as a...
•NAM
•PAM
•PAM-antagonist - ✔✔PAM-antagonist
✔✔an allosteric modulator may be a NAM when applied with one agonist and a PAM
when applied with a different agonist.
•true
•false - ✔✔true
✔✔in which model of allosterism does the ligand actively cause a conformational
change in the receptor?
•concerted model
•sequential model - ✔✔sequential model
✔✔an allosteric ligand that increases binding of an orthosteric ligand will also increase
efficacy of that orthosteric ligand.
•true
•false - ✔✔false
✔✔which of the following types of kinase inhibitors does not inhibit ATP binding to the
kinase?
•orthosteric
•direct allosteric
SCORED A+
✔✔after addition of an agonist, you measure an increase in mRNA from the
whatchamacallit gene. this is an example of a group ___ assay.
•1
•2
•3 - ✔✔3
✔✔you have cells that express fluorescent beta-arrestin. upon addition of an agonist
that binds to GPCRs, would you expect fluorescence located at the cell membrane to
increase or decrease after giving time for the system to equilibrate?
•increase
•decrease - ✔✔decrease
✔✔an antagonist that has a concentration where addition of more antagonist will have
no additional measurable effect is called...
•saturable
•unsaturable
•surmountable
•unsurmountable - ✔✔saturable
✔✔a more potent antagonist will have a ___ pA2.
•higher
•lower - ✔✔lower
✔✔a schind analysis reveals a graph that resembles a y=x^2 graph. this antagonist is
most likely...
•noncompetitive
•competitive
•cooperative
•interacting with heterogenous receptors
•not at equilibrium - ✔✔noncompetitive
✔✔a reversible inverse agonist applied to a system that does not contain activity will
appear to behave most like a[n] ___ antagonist.
•noncompetitive
•competitive
, •allosteric - ✔✔competitive
✔✔it is possible for a competitive antagonist and an allosteric modulator to have
synergistic effects in blocking agonist binding.
•true
•false - ✔✔true
✔✔an allosteric modulator with alpha>1, beta=1 is best classified as a...
•NAM
•PAM
•PAM-antagonist - ✔✔PAM
✔✔an allosteric modulator that increases affinity while decreasing efficacy is best
classified as a...
•NAM
•PAM
•PAM-antagonist - ✔✔PAM-antagonist
✔✔an allosteric modulator may be a NAM when applied with one agonist and a PAM
when applied with a different agonist.
•true
•false - ✔✔true
✔✔in which model of allosterism does the ligand actively cause a conformational
change in the receptor?
•concerted model
•sequential model - ✔✔sequential model
✔✔an allosteric ligand that increases binding of an orthosteric ligand will also increase
efficacy of that orthosteric ligand.
•true
•false - ✔✔false
✔✔which of the following types of kinase inhibitors does not inhibit ATP binding to the
kinase?
•orthosteric
•direct allosteric
