WGU D027 ADVANCED PATHO
PHARMACOLOGICAL FOUNDATIONS 2025-
2026 DETAILED LATEST EXAM WITH
ACTUAL EXAM QUESTIONS AND CORRECT
ANSWERS GRADED A+
What is celiac disease? Correct Answer - Autoimmune disease
- Damages to the small intestinal epithelium when there is
ingestion of gluten
- Loss of mucosal surface and brush border enzymes leads to
severe malabsorption that is more pronounced in the duodenum
and jejunum
What strong genetic disposition does celiac disease have?
Correct Answer - Human leukocyte antigen DQ2 (HLA-DQ2) and
HLA-DQ5
What test is recommended for celiac disease? Correct Answer -
IgA-tTG
- Total IgA
- Simple, inexpensive, widely available, typically covered by
insurance, and is very accurate in untreated celiac disease
,What are the recommended tests for celiac disease? Correct
Answer - Total IgA
- IgA-tTg
- IgA-EMA
- If IgA is deficient, it is recommended that IgG/IgA-DGP also be
ordered
What are diagnostic methods of celiac disease? Correct Answer
- Serologic measurements of antiendomysial and
antitrandsglutaminase IgA antibodies and HLA-DQ2 or HLA-DQ8
- Duodenal biopsy
Why is it important to remain on a normal, gluten-containing diet
prior to testing for celiac disease? Correct Answer - Alter the
results of the test
- If the blood tests and symptoms indicate the disease, a
physician will likely suggest a biopsy for the lining of the small
intestine to confirm the diagnosis
Which part of the bowels is more affected by celiac disease?
Correct Answer - Duodenum and jejunum
What are some symptoms of celiac disease? Correct Answer -
Pale, greasy, bulky, and foul smelling diarrhea
- Easily bruises and/or bleeds
,- Abdominal pain
- Hypomagnesemia and hypocalcemia (irritability, tremors,
convulsions, tetany, bone pain, osteomalacia, and dental
abnormalities)
What is the treatment for celiac disease? Correct Answer -
Lifelong adherence to a gluten free diet
- Steroids and immunosuppressants may be required
What are some foods that are contain gluten? Correct Answer -
Wheat
- Rye
- Barley
- Malt
What is Crohn's disease? Correct Answer - A chronic
inflammatory bowel disease that affects the lining of the digestive
tract
- May cause intestinal bleeding, chronic diarrhea, abdominal pain,
cramping, fissure, malabsorption, ileus, bowel resection,
pancreatitis, mouth ulcers, kidney stones, inflammation of the
eyes
- A lot of times, they do not absorb iron and some other minerals
and vitamins, thus, patients may have issues getting all minerals
and vitamins
, What are tests are used in the diagnosing Crohn's disease?
Correct Answer - Anti-saccharomyces antibody test (ASCA)
- CBC (H/H, WBC)
- Heme-occult
- C-reactive protein (sign of inflammation)
- Electrolyte panel (K due to diarrhea)
- Erythrocyte sedimentation rate (ESR) (amount of inflammation)
- Iron and B12 levels
- KUB
- Upper endoscopy
- Barium x-rays
- CT/MRI (external view)
- Video capsule endoscopy
Which tests may show lesions for patients with Crohn's disease?
Correct Answer - Barium x-ray - in the small intestines
- Colonoscopy or sigmoidoscopy (primarily) - in the large
intestines
Which two lab tests measure inflammation? Correct Answer - C-
reactive protein
PHARMACOLOGICAL FOUNDATIONS 2025-
2026 DETAILED LATEST EXAM WITH
ACTUAL EXAM QUESTIONS AND CORRECT
ANSWERS GRADED A+
What is celiac disease? Correct Answer - Autoimmune disease
- Damages to the small intestinal epithelium when there is
ingestion of gluten
- Loss of mucosal surface and brush border enzymes leads to
severe malabsorption that is more pronounced in the duodenum
and jejunum
What strong genetic disposition does celiac disease have?
Correct Answer - Human leukocyte antigen DQ2 (HLA-DQ2) and
HLA-DQ5
What test is recommended for celiac disease? Correct Answer -
IgA-tTG
- Total IgA
- Simple, inexpensive, widely available, typically covered by
insurance, and is very accurate in untreated celiac disease
,What are the recommended tests for celiac disease? Correct
Answer - Total IgA
- IgA-tTg
- IgA-EMA
- If IgA is deficient, it is recommended that IgG/IgA-DGP also be
ordered
What are diagnostic methods of celiac disease? Correct Answer
- Serologic measurements of antiendomysial and
antitrandsglutaminase IgA antibodies and HLA-DQ2 or HLA-DQ8
- Duodenal biopsy
Why is it important to remain on a normal, gluten-containing diet
prior to testing for celiac disease? Correct Answer - Alter the
results of the test
- If the blood tests and symptoms indicate the disease, a
physician will likely suggest a biopsy for the lining of the small
intestine to confirm the diagnosis
Which part of the bowels is more affected by celiac disease?
Correct Answer - Duodenum and jejunum
What are some symptoms of celiac disease? Correct Answer -
Pale, greasy, bulky, and foul smelling diarrhea
- Easily bruises and/or bleeds
,- Abdominal pain
- Hypomagnesemia and hypocalcemia (irritability, tremors,
convulsions, tetany, bone pain, osteomalacia, and dental
abnormalities)
What is the treatment for celiac disease? Correct Answer -
Lifelong adherence to a gluten free diet
- Steroids and immunosuppressants may be required
What are some foods that are contain gluten? Correct Answer -
Wheat
- Rye
- Barley
- Malt
What is Crohn's disease? Correct Answer - A chronic
inflammatory bowel disease that affects the lining of the digestive
tract
- May cause intestinal bleeding, chronic diarrhea, abdominal pain,
cramping, fissure, malabsorption, ileus, bowel resection,
pancreatitis, mouth ulcers, kidney stones, inflammation of the
eyes
- A lot of times, they do not absorb iron and some other minerals
and vitamins, thus, patients may have issues getting all minerals
and vitamins
, What are tests are used in the diagnosing Crohn's disease?
Correct Answer - Anti-saccharomyces antibody test (ASCA)
- CBC (H/H, WBC)
- Heme-occult
- C-reactive protein (sign of inflammation)
- Electrolyte panel (K due to diarrhea)
- Erythrocyte sedimentation rate (ESR) (amount of inflammation)
- Iron and B12 levels
- KUB
- Upper endoscopy
- Barium x-rays
- CT/MRI (external view)
- Video capsule endoscopy
Which tests may show lesions for patients with Crohn's disease?
Correct Answer - Barium x-ray - in the small intestines
- Colonoscopy or sigmoidoscopy (primarily) - in the large
intestines
Which two lab tests measure inflammation? Correct Answer - C-
reactive protein
