· Describe . A
M O.
Of ACE inhibitors and ARBs
· Clinical use of ACE inhibitors and ARBs
· side effects
both
·
compare and contrast the effects of drugs
Renin-Angiotensin-Aldosterone system
Angiotensin converting enzyme
·
Catalysing the conversion of Angl to Ang 11
· Breaks down bradykinin
ACE inhibitors
·
captopril >
-
heart failure
2nd line treatment
Ramipril >
hypertension (1st or
-
·
·
Enalapril -
prophylactic in ischaemic heart disease
side effect/intolerance
·
persistent dry cough > increased levels
-
of bradykinin sensitises airways
·
Angioedma >
-
increased levels of bradykin > increases
-
vascular permeability
more common for women and those of African descent