NR 565 Week 1, 2 3, 4, 5, 6, 7, Quiz and Midterm
Questions And Answers Latest Update 2026
package
3 possible outcomes of phase 1 metabolism - - answerOxidized (most
common)
Reduced
Hydrolyzed
Oxidation - - answerDrug becomes completely inactive
Reduction - - answerDrug becomes partially inactive; one or more
metabolites remain active
Hydrolization - - answerOriginal drug is not pharmacologically active;
one metabolite remains active
Alteration in CYP450 metabolism causes ___ - - answerMedication
interactions
,Substrate - - answerXenobiotics that require the metabolic process of
the body to activate or de-activate the substance
Understanding substrates, inhibitors, and induces is crucial when
prescribing ___ - - answerMedications for seizures, depression, and
psychosis
Inhibitors - - answerMedications that inhibit metabolic activity of one
or more CYP450 enzymes
Slows/blocks enzyme's metabolic activity that other medications are
dependent on
Dangers of inhibitors - - answerCan cause increased levels of other
meds, prolonged pharmacological effect, and potential toxicity
Inhibitors: VISA CK GQ - - answerValproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit
Quinidine
, Inducers - - answerXenobiotics (medications and environmental agents)
that elevate CYP450 enzyme activity by increasing enzyme synthesis
Additional sites for biotransformation = increased medication
metabolism
Rifampin - - answerInducer with short half-life
Phenobarbital - - answerInducer with long half-life
Carbamazepine - - answerPotent inducer; metabolized by the same
CYP450 enzyme it induces
Start at low dose, increase weekly due to steady decrease in half-life
over time
Inducers: CRAP GPS - - answerCarbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
Questions And Answers Latest Update 2026
package
3 possible outcomes of phase 1 metabolism - - answerOxidized (most
common)
Reduced
Hydrolyzed
Oxidation - - answerDrug becomes completely inactive
Reduction - - answerDrug becomes partially inactive; one or more
metabolites remain active
Hydrolization - - answerOriginal drug is not pharmacologically active;
one metabolite remains active
Alteration in CYP450 metabolism causes ___ - - answerMedication
interactions
,Substrate - - answerXenobiotics that require the metabolic process of
the body to activate or de-activate the substance
Understanding substrates, inhibitors, and induces is crucial when
prescribing ___ - - answerMedications for seizures, depression, and
psychosis
Inhibitors - - answerMedications that inhibit metabolic activity of one
or more CYP450 enzymes
Slows/blocks enzyme's metabolic activity that other medications are
dependent on
Dangers of inhibitors - - answerCan cause increased levels of other
meds, prolonged pharmacological effect, and potential toxicity
Inhibitors: VISA CK GQ - - answerValproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit
Quinidine
, Inducers - - answerXenobiotics (medications and environmental agents)
that elevate CYP450 enzyme activity by increasing enzyme synthesis
Additional sites for biotransformation = increased medication
metabolism
Rifampin - - answerInducer with short half-life
Phenobarbital - - answerInducer with long half-life
Carbamazepine - - answerPotent inducer; metabolized by the same
CYP450 enzyme it induces
Start at low dose, increase weekly due to steady decrease in half-life
over time
Inducers: CRAP GPS - - answerCarbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
