Nuclear Medicine Technology
NMT 2710
Exam 2 (70pts)
Name:_____________________________________Date:______________
1. Which method of radiolabeling does 18F-FDG utilize?
a. Isotope exchange c. Use of bi-functional
b. Foreign label chelating agent
d. Biosynthesis
2. T/ F. Covalent bonds are formed when one atom donates an electron to another atom that is
need of an electron. These disassociate easily in a solution and are charged particles.
3. Please list the mechanism of decay for the following: (4pts)
99
Mo
133
Xe
125
I
131
I
4. Please list the following radiopharmaceuticals method of production. (3pts)
201
Tl-thallous chloride
89
Sr- strontium chloride
67
Ga-Gallium citrate
5. Dose calibrator readings show that a vial contains 329mCi of 99mTc and 45uCi of 99Mo. Please
indicate the 99Mo concentration and if it falls within acceptable limits.
6. T/ F. Hydrolyzed 99mTc is bound to the desired compound in our radiopharmaceutical
preparation.
7. A bone agent was prepared at 7:30am and a patient dose administered at 1:00pm. The patient
was scanned 2 hours post injection and the bone scan shows activity in the salivary glands
and stomach. This activity is most likely due to:
a. scanning too soon after injection of MDP
b. infiltration of the dose
c. presence of Tc-tin colloids
, d. presence of free or unbound Tc99m pertechnetate
8. What is Tc99m’s oxidation state when it is eluted from the generator?
a. -1 c. +4
b. +2 d. +7
9. Tc99m is most commonly reduced to this state for efficient tagging.
a. -1 c. +4
b. +2 d. +7
10. The presence of Mo99 in the Tc99m pertechnetate eluate is a:
a. Radionuclide impurity d. Pyrogenic impurity
b. Radiochemical impurity e. Chemical impurity
c. Colloidal impurity
11. Choose the best description for the method of localization: active transport.
a. mechanical process when particle can get stuck if too big
b. movement of materials against the concentration gradient
c. substances are broken down to yield energy for vital process while others
are synthesized
d. movement of materials along the concentration gradient
12. Testing for pyrogens is achieved by:
a. Radiochromatography
b. Limulus ameobocyte lysate assay
c. ITLC
d. Sterility
13. If a compound travels 2.6cm and the solvent front travels 38mm. Calculate the Retention
factor.
a. .068
b. .68
c. 1.46
d. 14.6
14. The structural property of a contrast agent regarding the number of particles in solution
compared with blood is known as:
a. Osmolality
b. Iconicity
c. Valence
d. Viscosity
15. When imaging 18F-FDG, the energy being imaged is
a. 3.15MeV c. 511keV
b. 635keV d. 110keV
16. Compared to 2D PET imaging, when imaging in 3D,
a. Shorter acquisition times can be used
b. A higher dose must be used
NMT 2710
Exam 2 (70pts)
Name:_____________________________________Date:______________
1. Which method of radiolabeling does 18F-FDG utilize?
a. Isotope exchange c. Use of bi-functional
b. Foreign label chelating agent
d. Biosynthesis
2. T/ F. Covalent bonds are formed when one atom donates an electron to another atom that is
need of an electron. These disassociate easily in a solution and are charged particles.
3. Please list the mechanism of decay for the following: (4pts)
99
Mo
133
Xe
125
I
131
I
4. Please list the following radiopharmaceuticals method of production. (3pts)
201
Tl-thallous chloride
89
Sr- strontium chloride
67
Ga-Gallium citrate
5. Dose calibrator readings show that a vial contains 329mCi of 99mTc and 45uCi of 99Mo. Please
indicate the 99Mo concentration and if it falls within acceptable limits.
6. T/ F. Hydrolyzed 99mTc is bound to the desired compound in our radiopharmaceutical
preparation.
7. A bone agent was prepared at 7:30am and a patient dose administered at 1:00pm. The patient
was scanned 2 hours post injection and the bone scan shows activity in the salivary glands
and stomach. This activity is most likely due to:
a. scanning too soon after injection of MDP
b. infiltration of the dose
c. presence of Tc-tin colloids
, d. presence of free or unbound Tc99m pertechnetate
8. What is Tc99m’s oxidation state when it is eluted from the generator?
a. -1 c. +4
b. +2 d. +7
9. Tc99m is most commonly reduced to this state for efficient tagging.
a. -1 c. +4
b. +2 d. +7
10. The presence of Mo99 in the Tc99m pertechnetate eluate is a:
a. Radionuclide impurity d. Pyrogenic impurity
b. Radiochemical impurity e. Chemical impurity
c. Colloidal impurity
11. Choose the best description for the method of localization: active transport.
a. mechanical process when particle can get stuck if too big
b. movement of materials against the concentration gradient
c. substances are broken down to yield energy for vital process while others
are synthesized
d. movement of materials along the concentration gradient
12. Testing for pyrogens is achieved by:
a. Radiochromatography
b. Limulus ameobocyte lysate assay
c. ITLC
d. Sterility
13. If a compound travels 2.6cm and the solvent front travels 38mm. Calculate the Retention
factor.
a. .068
b. .68
c. 1.46
d. 14.6
14. The structural property of a contrast agent regarding the number of particles in solution
compared with blood is known as:
a. Osmolality
b. Iconicity
c. Valence
d. Viscosity
15. When imaging 18F-FDG, the energy being imaged is
a. 3.15MeV c. 511keV
b. 635keV d. 110keV
16. Compared to 2D PET imaging, when imaging in 3D,
a. Shorter acquisition times can be used
b. A higher dose must be used
