DETAILED ANSWERS|LATEST UPDATE!!!!!!2026|GUARANTEED
CORRECT = 100
100
INCORRECT=0
STUDY MATERIALS.......DESIGNED TO HELP YOU SUCCEED
1
, SPOTLIGHT 1
DETAILED ANSWERS|LATEST
UPDATE!!!!!!2026|GUARANTEED PASS|GRADED
What blood values should be monitored with carbamazepine? - ANSWER Plasma
carbamazepine levels should be monitored on a regular basis. The therapeutic range is 4 to
12 mcg/L. Higher levels can lead to toxic symptoms consisting of initial adverse effects and
also hypertension, tachycardia, ECG changes, stupor, agitation, nystagmus, urinary retention,
respiratory depression, seizures, and coma. Children and elderly patient may develop
toxicity levels below 12.
CBC every 3 to 4 months
Affects RBC, WBC, Platelets
Agranulocytosis, Anemia
What is the pharmacodynamics of carbamazepine? - ANSWER Carbamazepine is
metabolized in the liver and has the unique ability to induce its own metabolism
(autoinduction). Due to autoinduction, initial concentrations within therapeutic range may
later fall despite good compliance. It also induces the metabolism of many CYP450 enzymes
and other substances. Slowly but well absorbed half life of about 30 hours, shortens to 15
hours when given repeatedly
The exact mechanism of action of carbamazepine is not known, but they are thought to
affect the sodium channels, slowing influx of sodium in the cortical neurons and slowing the
spread of abnormal activity. Carbamazepine exerts its effect by depressing transmission in
the nucleus ventralis anterior of the thalamus. This area is associated with the spread of
seizure discharge.
2
CORRECT = 100
100
INCORRECT=0
STUDY MATERIALS.......DESIGNED TO HELP YOU SUCCEED
1
, SPOTLIGHT 1
DETAILED ANSWERS|LATEST
UPDATE!!!!!!2026|GUARANTEED PASS|GRADED
What blood values should be monitored with carbamazepine? - ANSWER Plasma
carbamazepine levels should be monitored on a regular basis. The therapeutic range is 4 to
12 mcg/L. Higher levels can lead to toxic symptoms consisting of initial adverse effects and
also hypertension, tachycardia, ECG changes, stupor, agitation, nystagmus, urinary retention,
respiratory depression, seizures, and coma. Children and elderly patient may develop
toxicity levels below 12.
CBC every 3 to 4 months
Affects RBC, WBC, Platelets
Agranulocytosis, Anemia
What is the pharmacodynamics of carbamazepine? - ANSWER Carbamazepine is
metabolized in the liver and has the unique ability to induce its own metabolism
(autoinduction). Due to autoinduction, initial concentrations within therapeutic range may
later fall despite good compliance. It also induces the metabolism of many CYP450 enzymes
and other substances. Slowly but well absorbed half life of about 30 hours, shortens to 15
hours when given repeatedly
The exact mechanism of action of carbamazepine is not known, but they are thought to
affect the sodium channels, slowing influx of sodium in the cortical neurons and slowing the
spread of abnormal activity. Carbamazepine exerts its effect by depressing transmission in
the nucleus ventralis anterior of the thalamus. This area is associated with the spread of
seizure discharge.
2
