Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1.
Which principle best defines evidence-based medical practice
as described in Harrison’s?
A. Reliance on expert opinion over patient values
B. Use of randomized trials only for decision-making
C. Integration of best evidence with clinical expertise and
patient preferences
D. Prioritization of cost containment over outcomes
Correct Answer: C
Rationale: Harrison’s emphasizes that evidence-based
medicine integrates high-quality research evidence with
clinician expertise and individual patient values to guide care
,decisions.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 – The Practice of Medicine
2.
A nurse educating a patient on lifestyle modification is directly
supporting which level of disease prevention?
A. Tertiary
B. Secondary
C. Primary
D. Quaternary
Correct Answer: C
Rationale: Primary prevention focuses on reducing disease risk
before onset through health promotion and behavioral
interventions.
Citation: Harrison’s, 22nd ed., Ch. 2 – Promoting Good Health
3.
Which factor is most strongly associated with vaccine
hesitancy according to Harrison’s?
A. Limited vaccine availability
B. Distrust in health care institutions
C. High health literacy
D. Prior immunization compliance
,Correct Answer: B
Rationale: Harrison’s identifies mistrust of medical systems
and institutions as a key driver of vaccine opposition and
hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4.
When a patient lacks decision-making capacity, which
standard should guide clinical decisions?
A. Provider preference
B. Institutional policy
C. Substituted judgment or best-interest standard
D. Legal counsel only
Correct Answer: C
Rationale: Harrison’s states that decisions should reflect the
patient’s known wishes (substituted judgment) or best
interests if wishes are unknown.
Citation: Harrison’s, 22nd ed., Ch. 4 – Decision-Making in
Clinical Medicine
5.
Which concept is central to precision medicine?
, A. Uniform treatment protocols
B. Population-based averages
C. Genetic and molecular variability
D. Symptom-based algorithms
Correct Answer: C
Rationale: Precision medicine tailors prevention and
treatment strategies based on individual genetic,
environmental, and lifestyle differences.
Citation: Harrison’s, 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6.
Which screening principle improves the benefit-to-harm ratio
of preventive testing?
A. Screening all populations equally
B. Screening only symptomatic individuals
C. Targeting high-risk populations
D. Using the most sensitive test available
Correct Answer: C
Rationale: Harrison’s emphasizes targeted screening in high-
risk groups to maximize benefit and reduce unnecessary harm.
Citation: Harrison’s, 22nd ed., Ch. 6 – Screening and
Prevention of Disease
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1.
Which principle best defines evidence-based medical practice
as described in Harrison’s?
A. Reliance on expert opinion over patient values
B. Use of randomized trials only for decision-making
C. Integration of best evidence with clinical expertise and
patient preferences
D. Prioritization of cost containment over outcomes
Correct Answer: C
Rationale: Harrison’s emphasizes that evidence-based
medicine integrates high-quality research evidence with
clinician expertise and individual patient values to guide care
,decisions.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 – The Practice of Medicine
2.
A nurse educating a patient on lifestyle modification is directly
supporting which level of disease prevention?
A. Tertiary
B. Secondary
C. Primary
D. Quaternary
Correct Answer: C
Rationale: Primary prevention focuses on reducing disease risk
before onset through health promotion and behavioral
interventions.
Citation: Harrison’s, 22nd ed., Ch. 2 – Promoting Good Health
3.
Which factor is most strongly associated with vaccine
hesitancy according to Harrison’s?
A. Limited vaccine availability
B. Distrust in health care institutions
C. High health literacy
D. Prior immunization compliance
,Correct Answer: B
Rationale: Harrison’s identifies mistrust of medical systems
and institutions as a key driver of vaccine opposition and
hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4.
When a patient lacks decision-making capacity, which
standard should guide clinical decisions?
A. Provider preference
B. Institutional policy
C. Substituted judgment or best-interest standard
D. Legal counsel only
Correct Answer: C
Rationale: Harrison’s states that decisions should reflect the
patient’s known wishes (substituted judgment) or best
interests if wishes are unknown.
Citation: Harrison’s, 22nd ed., Ch. 4 – Decision-Making in
Clinical Medicine
5.
Which concept is central to precision medicine?
, A. Uniform treatment protocols
B. Population-based averages
C. Genetic and molecular variability
D. Symptom-based algorithms
Correct Answer: C
Rationale: Precision medicine tailors prevention and
treatment strategies based on individual genetic,
environmental, and lifestyle differences.
Citation: Harrison’s, 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6.
Which screening principle improves the benefit-to-harm ratio
of preventive testing?
A. Screening all populations equally
B. Screening only symptomatic individuals
C. Targeting high-risk populations
D. Using the most sensitive test available
Correct Answer: C
Rationale: Harrison’s emphasizes targeted screening in high-
risk groups to maximize benefit and reduce unnecessary harm.
Citation: Harrison’s, 22nd ed., Ch. 6 – Screening and
Prevention of Disease
