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USMLE Step 1 First Aid Exam – Questions with Verified Correct Solutions | 100% Guaranteed Pass | Latest 2026 Prep

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Ace your USMLE Step 1 with this comprehensive First Aid exam prep resource. Includes exam-style questions with 100% verified correct solutions, designed to reinforce high-yield concepts, clinical reasoning, and exam strategies. Perfect for self-study, practice exams, and final review, this A+ rated resource is structured to help you pass confidently on your first attempt.

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1
Usmle




Usmle Step 1 First Aid Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
Hypersensitivity vasculitis associated with hemorrhagic urticaria and
upper respiratory tract infections - diagnosis? - ANS ✓henoch-schonlein
purpura


Most common tumor of infancy - ANS ✓hemangioma



Charcot's triad of multiple sclerosis - ANS ✓nystagmus, intention
tremor, scanning speech (where the same emphasis is put on each syllable
like scanning a poem)


Most common causes of dic - ANS ✓gram-negative sepsis, obstetric
complications, cancer, burn trauma


Most common cause of myocarditis - ANS ✓coxsackie b



Kussmaul hyperpnea - diagnosis? - ANS ✓diabetic ketoacidosis



Lisch nodules - diagnosis? - ANS ✓neurofibromatosis (von
recklinghausen's disease)


Polyneuropathy, cardiac pathology, and edema - diagnosis?

Usmle Step 1 First Aid

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Usmle

- what causes it? - ANS ✓wet beriberi (vitamin b1 deficiency)


Most common malignancy associated with noninfectious fever - ANS
✓Hodgkin’s disease



Port-wine stain - diagnosis? - ANS ✓hemangioma


What is trousseau's sign of malignancy?

- possible diagnoses? - ANS ✓migratory thrombophlebitis
- visceral cancer or pancreatic adenocarcinoma


Homer wright rosettes - diagnosis? - ANS ✓neuroblastoma


What is trousseau's sign of latent tetany?

- diagnosis? - ANS ✓carpal spasm
- hypocalcemia


What is Virchow’s triad?

- predilection for what? - ANS ✓blood stasis, endothelial damage,
hypercoagulation
- pulmonary embolism


What is von recklinghausen's disease of bone? - ANS ✓osteitis fibrosa
cystica ("brown tumor")




Usmle Step 1 First Aid

, 3
Usmle

Adrenal hemorrhage associated with meningococcemia - diagnosis? -
ANS ✓waterhouse-friderichsen syndrome


Most common cause of hemochromatosis

- causes risk of? - ANS ✓multiple blood transfusions
- can cause chf and increased risk of hepatocellular carcinoma


Mechanism of action of macrolides and clindamycin? - ANS ✓bind 50s
subunit and block translocation


Most common cause of congenital adrenal hyperplasia - ANS ✓21-
hydroxylase deficiency


Most common tumor of the adrenal medulla in kids

- benign or malignant? - ANS ✓neuroblastoma - malignant



Most common cause of siadh - ANS ✓small cell carcinoma of the lung


Most common cause of cushing's syndrome

- 2nd most common? - ANS ✓corticosteroid therapy
- excess acth secretion by pituitary is 2nd


Most common cause of hypopituitarism - ANS ✓adenoma



Suboccipital lymphadenopathy - diagnosis? - ANS ✓rubella




Usmle Step 1 First Aid

, 4
Usmle

Most common vasculitis
- poses risk for?

- what causes this? - ANS ✓temporal arteritis
- risk of ipsilateral blindness - due to thrombosis of opthalmic artery


Most common cause of hepatocellular carcinoma - ANS ✓cirrhotic liver,
often due to hepatitis b and c


Most common cause of viral encephalitis - ANS ✓hsv


What is the defect in chediak-higashi syndrome?

- symptoms? - ANS ✓defect in microtubule polymerization, causing
decreased phagocytosis
- symptoms: recurrent pyogenic infections, partial albinism,
peripheral neuropathy


Most common cause of addison's

- 2nd most common? - ANS ✓autoimmune
- infection is 2nd


"smudge cell" - diagnosis? - ANS ✓cll



Most common cause of constrictive pericarditis - ANS ✓tuberculosis



Soap bubble on x-ray - diagnosis? - ANS ✓giant cell tumor of bone




Usmle Step 1 First Aid

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