NR 567
Warfarin
Inhibits diet K activation of clotting factors II (prothrombin), VII, IX, and X shaped in the liver.
Promtamine Sulfate
Heparin antidote
Vitamin K and Fresh frozen plasma
warfarin antidote
vitals, hematology, PT, INR, PTT
What assessments are to be executed on a affected person the usage of anticoagulants?
PTT
regular = 20-35 seconds; on heparin remedy purpose is 1.5 - 2.5 instances this
2-3
INR intention for warfarin remedy?
PT
Normal range is eleven-13.Five secs.
Aspirin
Common anti-platelet drug that can be purchased over-the-counter, utilized in patients
Clopidogrel
anti-platelet used to lessen threat of stroke in patients with history of MI, CAD, stents, skip.
Ticlopidine
,Anti-platelet drug reserved for patients allergic to aspirin; inhibits the binding of fibrinogen to
platelets all through the primary level of the clotting cascade. Used in sufferers that have already
had thrombotic stroke.
Dipyridamole
• Inhibits cyclic nucleotide phosphodiesterase and reuptake of adenosine, each actions result in
reduced platelet aggregation and reactivity.
Heparin
First-line anticoagulant used for STEMI; administered with ASA, clopidogrel, and a statin
Enoxaparin
can be used if the patient isn't always being referred for percutaneous coronary intervention, at
some point of an MI
Morphine
Alleviates pain no longer relieved with nitrates
Produces moderate vasodilation
Atorvastatin 80 mg loading dose, then daily.
Statin that is given at some stage in MI and the dose
Beta blocker
oral ______ ________ therapy inside 24 hours of cardiac event except contraindicated
Calcium Channel Blockers
If beta-blockers aren't tolerated, take into account
verapamil and dilatiazem
Examples of calcium channel blockers
162-325 MG
Aspirin loading dose for an NSTEMI
, 600 mg, 75mg each day
Loading dose of PLAVIX
Eptifibatide
Indicated for Acute coronary syndrome and used in mixture with heparin, aspirin, ticlid and
plavix; unfavourable reactions: bleeding, hypotension, thrombocytopenia, acute toxicity: reduced
muscle tone, dyspnea, lack of righting reflex; baseline PT/aPTT, H&H, platelet be counted
advert display; watch for bleeding; quick reversible so emergency approaches may additionally
nevertheless be carried out rapidly after discontinuing infusion
Tirofiban
Glycoprotein IIb/IIIa inhibitor used for high risk sufferers with deliberate PCTA
ACEs and ARBs
Reduces cardiac transforming publish-MI, Improves affected person survival in people with
coronary heart failure or anterior myocardial infarction
Reteplase
thrombolytic agent, Similar consequences as alteplase in terms of mortality NSTEMI
Easier to manage
Initial Bolus over 2 minutes, then repeat the equal dose bolus at 30 minutes
Alteplase
Initiates local fibrinolysis by way of binding to fibrin in a thrombus, converting plasminogen to
plasmin
Given as initial intravenous bolus, accompanied by separate infusions
Short 1/2-lifestyles
Administer with concurrent aspirin, clopidogrel, and anticoagulant therapy (unfractionated
heparin, enoxaparin, fondaparinux)
Tenecteplase
Similar efficacy to Alteplase
Lower price of non-cerebral bleeding occasions
Easier to useSingle bolus, weight-based totally
Fibrinolytic remedy
Warfarin
Inhibits diet K activation of clotting factors II (prothrombin), VII, IX, and X shaped in the liver.
Promtamine Sulfate
Heparin antidote
Vitamin K and Fresh frozen plasma
warfarin antidote
vitals, hematology, PT, INR, PTT
What assessments are to be executed on a affected person the usage of anticoagulants?
PTT
regular = 20-35 seconds; on heparin remedy purpose is 1.5 - 2.5 instances this
2-3
INR intention for warfarin remedy?
PT
Normal range is eleven-13.Five secs.
Aspirin
Common anti-platelet drug that can be purchased over-the-counter, utilized in patients
Clopidogrel
anti-platelet used to lessen threat of stroke in patients with history of MI, CAD, stents, skip.
Ticlopidine
,Anti-platelet drug reserved for patients allergic to aspirin; inhibits the binding of fibrinogen to
platelets all through the primary level of the clotting cascade. Used in sufferers that have already
had thrombotic stroke.
Dipyridamole
• Inhibits cyclic nucleotide phosphodiesterase and reuptake of adenosine, each actions result in
reduced platelet aggregation and reactivity.
Heparin
First-line anticoagulant used for STEMI; administered with ASA, clopidogrel, and a statin
Enoxaparin
can be used if the patient isn't always being referred for percutaneous coronary intervention, at
some point of an MI
Morphine
Alleviates pain no longer relieved with nitrates
Produces moderate vasodilation
Atorvastatin 80 mg loading dose, then daily.
Statin that is given at some stage in MI and the dose
Beta blocker
oral ______ ________ therapy inside 24 hours of cardiac event except contraindicated
Calcium Channel Blockers
If beta-blockers aren't tolerated, take into account
verapamil and dilatiazem
Examples of calcium channel blockers
162-325 MG
Aspirin loading dose for an NSTEMI
, 600 mg, 75mg each day
Loading dose of PLAVIX
Eptifibatide
Indicated for Acute coronary syndrome and used in mixture with heparin, aspirin, ticlid and
plavix; unfavourable reactions: bleeding, hypotension, thrombocytopenia, acute toxicity: reduced
muscle tone, dyspnea, lack of righting reflex; baseline PT/aPTT, H&H, platelet be counted
advert display; watch for bleeding; quick reversible so emergency approaches may additionally
nevertheless be carried out rapidly after discontinuing infusion
Tirofiban
Glycoprotein IIb/IIIa inhibitor used for high risk sufferers with deliberate PCTA
ACEs and ARBs
Reduces cardiac transforming publish-MI, Improves affected person survival in people with
coronary heart failure or anterior myocardial infarction
Reteplase
thrombolytic agent, Similar consequences as alteplase in terms of mortality NSTEMI
Easier to manage
Initial Bolus over 2 minutes, then repeat the equal dose bolus at 30 minutes
Alteplase
Initiates local fibrinolysis by way of binding to fibrin in a thrombus, converting plasminogen to
plasmin
Given as initial intravenous bolus, accompanied by separate infusions
Short 1/2-lifestyles
Administer with concurrent aspirin, clopidogrel, and anticoagulant therapy (unfractionated
heparin, enoxaparin, fondaparinux)
Tenecteplase
Similar efficacy to Alteplase
Lower price of non-cerebral bleeding occasions
Easier to useSingle bolus, weight-based totally
Fibrinolytic remedy
