Immunity and Hematoligic Disorders NSG 5003 Week 2
Study online at https://quizlet.com/_ggbx96
1. innate immunity: Immunity that is present before exposure and effective from birth. Responds to a broad
range of pathogens.
2. adaptive immunity: immunity or resistance to a specific pathogen; slower to respond, has memory
component
3. Antigens: foreign substances that trigger the attack of antibodies in the immune response.
4. antibody: a substance produced by the body that destroys or inactivates an antigen that has entered the body
5. Thymus: Gland in the thoracic cavity above the heart where T lymphocytes mature.
6. Basophils: A circulating leukocyte that produces histamine. Binds IgE Ex. anaphylaxis
7. Neutrophils: Most abundant white blood cell., The most abundant type of white blood cell. Phagocytic and
tend to self-destruct as they destroy foreign invaders, limiting their life span to a few days. First to attack infection
8. Eosinophils: a white blood cell containing granules that are readily stained by eosin. WBC involved in allergic
reactions and parsitic infections.
9. Monocytes: *A type of white blood cell that transforms into macrophages, extends pseudopods, and engulfs
huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a macrophage.
10. B cells: Cells manufactured in the bone marrow that create antibodies for isolating and destroying invading
bacteria and viruses. Prevents reinfection, immediate inflammatory response
11. memory b cells function: circulate the body, proliferate, and response quickly (via antibody synthesis)
to eliminate subsequent invasion by same antigen. (2ndary response - takes less time, ~5 days)
12. plasma cells: Cells that develop from B cells and produce antibodies.
13. T cells: Cells created in the thymus that produce substances that attack infected cells in the body.
14. Killer T cells: Lymphocytes that use enzymes to destroy the cell membranes of bacteria and other foreign
invaders.
15. Helper T cells: Activate macrophages, B cells and T cells.
16. innate immunity: Physical and chemical barriers that protect against all invaders *skin/dermis #1 barrier,
mucosa, chemical
17. inflammatory response: nonspecific defense reaction to tissue damage caused by injury or infection
and can begin shortly after injury and can last hours to days
18. vascular response: -facilitated by chemical mediators
-induces vasodilation and increases capillary permeability
-objective is to get more blood flowing to the injured area
* erythema, edema, heat, pain
1/8
, Immunity and Hematoligic Disorders NSG 5003 Week 2
Study online at https://quizlet.com/_ggbx96
19. mast cells: Cells that release chemicals (such as histamine) that promote inflammation.
20. Leukotrienes: mediator of mast cells, causes vasodilation and increases vascular permability
21. Cytokines: proteins secreted by cytotoxic T cells to aid in antigen destruction by antibody devlopment and wbc
recruitment
22. Prostaglandins: inhibit platelet aggregation causes pain, bronchoconstriction, and increased vascular per-
mability
23. Heparin: promotes new blood vessel growth, anticoagulant
24. Interferons: small proteins released from infected cells by viruses and stop the spread of virus to new cells.
25. Cellular Immunity (T cells): Cell mediated immunity, cells target virus infected cell
26. humoral immunity: specific immunity produced by B cells that produce antibodies that circulate in body
fluids
27. IgG: crosses placenta, main defense against bacteria. Passive immunity
28. IgM: first antibody made by the fetus, fights blood infections
29. IgA: found in membranes of gi tract and respiratory tract. important in local immunity
30. IgE: Protects body through presence in mucus membranes and skin. Responds to parasites and triggers allergic
reaction
31. IgD: Present in blood serum (in small amounts) and on B-cell surfaces; receptor for antigens; helps anchor cell
membranes.
32. nautral active immunity: pathogens enter body and cause illness
33. artificial active immunity: Production of one's own antibodies or T cells as a result of vaccination against
disease
34. natural passive immunity: Through antibody transfer across the placenta or in breast milk
35. artificial passive immunity: immunity which results from the administration of antibodies from
another animal against a dangerous pathogen.
36. Live vaccines: attenuated organisms used to stimulate cell-mediated immunity and create long term pro-
tection
37. Inactivated vaccines: Pathogen has been completely killed. Frequently requires boosters.
38. Type 1 IgE mediated: Immediate onset (mins): ingestion, injection, or direct contact
IgE formation: histamine and leukotriene release
s/s: erythema, edema, pruritus, contraction of bronchial smooth muscle, increased mucous secretion
2/8
Study online at https://quizlet.com/_ggbx96
1. innate immunity: Immunity that is present before exposure and effective from birth. Responds to a broad
range of pathogens.
2. adaptive immunity: immunity or resistance to a specific pathogen; slower to respond, has memory
component
3. Antigens: foreign substances that trigger the attack of antibodies in the immune response.
4. antibody: a substance produced by the body that destroys or inactivates an antigen that has entered the body
5. Thymus: Gland in the thoracic cavity above the heart where T lymphocytes mature.
6. Basophils: A circulating leukocyte that produces histamine. Binds IgE Ex. anaphylaxis
7. Neutrophils: Most abundant white blood cell., The most abundant type of white blood cell. Phagocytic and
tend to self-destruct as they destroy foreign invaders, limiting their life span to a few days. First to attack infection
8. Eosinophils: a white blood cell containing granules that are readily stained by eosin. WBC involved in allergic
reactions and parsitic infections.
9. Monocytes: *A type of white blood cell that transforms into macrophages, extends pseudopods, and engulfs
huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a macrophage.
10. B cells: Cells manufactured in the bone marrow that create antibodies for isolating and destroying invading
bacteria and viruses. Prevents reinfection, immediate inflammatory response
11. memory b cells function: circulate the body, proliferate, and response quickly (via antibody synthesis)
to eliminate subsequent invasion by same antigen. (2ndary response - takes less time, ~5 days)
12. plasma cells: Cells that develop from B cells and produce antibodies.
13. T cells: Cells created in the thymus that produce substances that attack infected cells in the body.
14. Killer T cells: Lymphocytes that use enzymes to destroy the cell membranes of bacteria and other foreign
invaders.
15. Helper T cells: Activate macrophages, B cells and T cells.
16. innate immunity: Physical and chemical barriers that protect against all invaders *skin/dermis #1 barrier,
mucosa, chemical
17. inflammatory response: nonspecific defense reaction to tissue damage caused by injury or infection
and can begin shortly after injury and can last hours to days
18. vascular response: -facilitated by chemical mediators
-induces vasodilation and increases capillary permeability
-objective is to get more blood flowing to the injured area
* erythema, edema, heat, pain
1/8
, Immunity and Hematoligic Disorders NSG 5003 Week 2
Study online at https://quizlet.com/_ggbx96
19. mast cells: Cells that release chemicals (such as histamine) that promote inflammation.
20. Leukotrienes: mediator of mast cells, causes vasodilation and increases vascular permability
21. Cytokines: proteins secreted by cytotoxic T cells to aid in antigen destruction by antibody devlopment and wbc
recruitment
22. Prostaglandins: inhibit platelet aggregation causes pain, bronchoconstriction, and increased vascular per-
mability
23. Heparin: promotes new blood vessel growth, anticoagulant
24. Interferons: small proteins released from infected cells by viruses and stop the spread of virus to new cells.
25. Cellular Immunity (T cells): Cell mediated immunity, cells target virus infected cell
26. humoral immunity: specific immunity produced by B cells that produce antibodies that circulate in body
fluids
27. IgG: crosses placenta, main defense against bacteria. Passive immunity
28. IgM: first antibody made by the fetus, fights blood infections
29. IgA: found in membranes of gi tract and respiratory tract. important in local immunity
30. IgE: Protects body through presence in mucus membranes and skin. Responds to parasites and triggers allergic
reaction
31. IgD: Present in blood serum (in small amounts) and on B-cell surfaces; receptor for antigens; helps anchor cell
membranes.
32. nautral active immunity: pathogens enter body and cause illness
33. artificial active immunity: Production of one's own antibodies or T cells as a result of vaccination against
disease
34. natural passive immunity: Through antibody transfer across the placenta or in breast milk
35. artificial passive immunity: immunity which results from the administration of antibodies from
another animal against a dangerous pathogen.
36. Live vaccines: attenuated organisms used to stimulate cell-mediated immunity and create long term pro-
tection
37. Inactivated vaccines: Pathogen has been completely killed. Frequently requires boosters.
38. Type 1 IgE mediated: Immediate onset (mins): ingestion, injection, or direct contact
IgE formation: histamine and leukotriene release
s/s: erythema, edema, pruritus, contraction of bronchial smooth muscle, increased mucous secretion
2/8
