Medical-Surgical Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




Harrison’s Principles of Internal Medicine, 22nd ed.
Chapters 1–12 | Integrated Nursing Test Bank (20 MCQs)


1. Which principle best defines the practice of medicine as
described in Harrison’s?
A. Application of standardized protocols
B. Use of diagnostic technology
C. Integration of science, clinical judgment, and humanism
D. Reliance on population-based guidelines
Correct Answer: C
Rationale: Harrison’s emphasizes medicine as a professional
discipline combining biomedical science, clinical reasoning,
ethical responsibility, and compassionate care—not protocol
use alone.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 The Practice of Medicine

,2. A nurse counseling a patient on health promotion should
prioritize which intervention for the greatest population
health impact?
A. Genetic testing
B. Lifestyle modification
C. Advanced diagnostics
D. Pharmacologic prophylaxis
Correct Answer: B
Rationale: Harrison’s identifies lifestyle behaviors (nutrition,
physical activity, tobacco avoidance) as the most powerful
determinants of preventable disease burden.
Citation: Harrison’s, 22nd ed., Ch. 2 Promoting Good Health


3. Vaccine hesitancy is most strongly associated with which
factor?
A. Limited vaccine availability
B. Cultural distrust and misinformation
C. High adverse event rates
D. Genetic susceptibility
Correct Answer: B
Rationale: Harrison’s highlights misinformation, distrust of
institutions, and perceived risk as central drivers of vaccine
opposition—not lack of access alone.

, Citation: Harrison’s, 22nd ed., Ch. 3 Vaccine Opposition and
Hesitancy


4. Which cognitive bias most commonly contributes to
diagnostic error?
A. Anchoring bias
B. Random error
C. Confirmation bias
D. Availability bias
Correct Answer: A
Rationale: Anchoring—fixating on an initial diagnosis despite
new evidence—is cited as a leading cause of diagnostic failure
in clinical medicine.
Citation: Harrison’s, 22nd ed., Ch. 4 Decision-Making in Clinical
Medicine


5. Precision medicine primarily seeks to:
A. Replace clinical judgment
B. Standardize treatment protocols
C. Tailor care based on individual variability
D. Reduce health care costs
Correct Answer: C
Rationale: Harrison’s defines precision medicine as
individualized care informed by genetic, environmental, and