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Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The Practice of Medicine
1. Which principle best defines modern medical practice as
described in Harrison’s?
A. Disease-focused intervention
B. Evidence-based, patient-centered decision-making
C. Technology-driven diagnosis
D. Physician-directed care
Correct Answer: B
Rationale: Harrison emphasizes integration of evidence, clinical
expertise, and patient values as the foundation of modern
medical practice.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1


2. Promoting Good Health

,2. Which intervention has the greatest population-level impact
on reducing morbidity?
A. Advanced imaging
B. Lifestyle modification
C. Genetic screening
D. Hospital-based treatment
Correct Answer: B
Rationale: Health promotion through behavior modification
(diet, exercise, smoking cessation) yields the largest reduction
in chronic disease burden.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 2


3. Vaccine Opposition and Hesitancy
3. A major contributor to vaccine hesitancy identified in
Harrison’s is:
A. Cost of vaccines
B. Limited availability
C. Misinformation and mistrust
D. Provider shortage
Correct Answer: C
Rationale: Harrison highlights misinformation, cultural beliefs,
and distrust as central drivers of vaccine opposition.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 3

, 4. Decision-Making in Clinical Medicine
4. Which approach improves diagnostic accuracy in complex
clinical decisions?
A. Reliance on intuition
B. Pattern recognition alone
C. Bayesian reasoning
D. Defensive medicine
Correct Answer: C
Rationale: Bayesian reasoning integrates pretest probability
with new data to guide rational clinical decision-making.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 4


5. Precision Medicine and Clinical Care
5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Individualize prevention and treatment
C. Reduce healthcare costs
D. Standardize care pathways
Correct Answer: B
Rationale: Precision medicine tailors care based on genetic,
environmental, and lifestyle variability.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 5