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confidence
293 ALT for
/ questions & answers for quick study and test prep.
NR 293 ALT
Absorbed in intestines
Pass through liver to be metabolized (first pass)
Inactive matbolites
Absorption
Transports of a drug by the bloodstream to its site of action
Distribution
Heart
Liver
Kidneys
Areas of rapid distribution
Muscle
pg. 1
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293 ALT for
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Skin
Fat
Areas of slow distribution
Excretion
The elimination of drugs from the body and the main organ responsible is the
kidney
Metabolism
Involves the alteration of a drug into either an inactive metabolite, a more soluble
compound, a more present active metabolite, or a less active metabolite
Liver
Organ most responsible for metabolism
Hepatic metabolism
Involves enzymes cytochrome 450 which target lipid soluble drugs
pg. 2
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293 ALT for
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Renal excretion
Accomplished through glomerular filtration active tubular reabsorption, and
active tubular secretion
Biliary excretion
Drugs though this route are metabolized by the liver and released as bile and
eliminated in feces
Which medications route are absorbed the slower
Which medication routes are absorbed the fastest
Half-life
Described the tie required for half of a given drug to be removed from the body
pg. 3
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293 ALT for
/ questions & answers for quick study and test prep.
I.e. a drug at peak level would be 100g after 8 hours would be reduced to 50g, 8
hours would be the half life
5 half lives
Considered to be removed from the body
Steady state
State in which the amount of drug removed via elimination is equal to the amount
of drug absorbed
1. Be sure to rotate area
2. Need to be applied at the same time each day
3. Clean site f old patch and new patch before admin
4. Activate it by holding your hand on the patch for about 10 sec
Transdermal patches
pg. 4
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NR 293 ALTandNR
confidence
293 ALT for
/ questions & answers for quick study and test prep.
NR 293 ALT
Absorbed in intestines
Pass through liver to be metabolized (first pass)
Inactive matbolites
Absorption
Transports of a drug by the bloodstream to its site of action
Distribution
Heart
Liver
Kidneys
Areas of rapid distribution
Muscle
pg. 1
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,Page 2 of 81 / Ideal for students seeking high-yield, exam-ready preparation
NR 293 ALTandNR
confidence
293 ALT for
/ questions & answers for quick study and test prep.
Skin
Fat
Areas of slow distribution
Excretion
The elimination of drugs from the body and the main organ responsible is the
kidney
Metabolism
Involves the alteration of a drug into either an inactive metabolite, a more soluble
compound, a more present active metabolite, or a less active metabolite
Liver
Organ most responsible for metabolism
Hepatic metabolism
Involves enzymes cytochrome 450 which target lipid soluble drugs
pg. 2
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,Page 3 of 81 / Ideal for students seeking high-yield, exam-ready preparation
NR 293 ALTandNR
confidence
293 ALT for
/ questions & answers for quick study and test prep.
Renal excretion
Accomplished through glomerular filtration active tubular reabsorption, and
active tubular secretion
Biliary excretion
Drugs though this route are metabolized by the liver and released as bile and
eliminated in feces
Which medications route are absorbed the slower
Which medication routes are absorbed the fastest
Half-life
Described the tie required for half of a given drug to be removed from the body
pg. 3
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, Page 4 of 81 / Ideal for students seeking high-yield, exam-ready preparation
NR 293 ALTandNR
confidence
293 ALT for
/ questions & answers for quick study and test prep.
I.e. a drug at peak level would be 100g after 8 hours would be reduced to 50g, 8
hours would be the half life
5 half lives
Considered to be removed from the body
Steady state
State in which the amount of drug removed via elimination is equal to the amount
of drug absorbed
1. Be sure to rotate area
2. Need to be applied at the same time each day
3. Clean site f old patch and new patch before admin
4. Activate it by holding your hand on the patch for about 10 sec
Transdermal patches
pg. 4
NR 293 ALT NR 293 ALT.pdf rank higher on Stuvia
