Medical-Surgical Nursing MCQ Study Guide & Practice Question Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




Nursing Examination MCQs
Harrison’s Principles of Internal Medicine, 22nd ed.
Chapters 1–13


1. Practice of Medicine
Which principle best defines evidence-based medical practice
as described in Harrison’s?
A. Reliance on expert opinion alone
B. Application of randomized trials without patient input
C. Integration of best evidence with clinical expertise and
patient values
D. Use of guidelines as mandatory rules
Correct Answer: C
Rationale: Evidence-based medicine integrates scientific
evidence, clinician expertise, and patient preferences to guide

,care decisions.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 – The Practice of Medicine


2. Promoting Good Health
Which intervention has the strongest population-level impact
on morbidity and mortality?
A. Advanced diagnostic testing
B. Lifestyle and behavioral modification
C. Precision pharmacotherapy
D. Specialty referral
Correct Answer: B
Rationale: Health promotion through behavioral modification
(diet, activity, smoking cessation) yields the greatest long-term
benefit.
Citation: Harrison’s, 22nd ed., Ch. 2 – Promoting Good Health


3. Vaccine Opposition and Hesitancy
Which factor most strongly contributes to vaccine hesitancy
according to Harrison’s?
A. Scientific uncertainty about efficacy
B. Access limitations alone
C. Mistrust and misinformation
D. Cost of vaccination

, Correct Answer: C
Rationale: Vaccine hesitancy is largely driven by
misinformation, distrust of institutions, and perceived risk
rather than scientific evidence.
Citation: Harrison’s, 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy


4. Clinical Decision-Making
Which cognitive bias increases diagnostic error by prematurely
settling on an initial diagnosis?
A. Availability bias
B. Anchoring bias
C. Confirmation bias
D. Framing effect
Correct Answer: B
Rationale: Anchoring bias occurs when clinicians rely too
heavily on early information and fail to adjust with new data.
Citation: Harrison’s, 22nd ed., Ch. 4 – Decision-Making in
Clinical Medicine


5. Precision Medicine
Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Eliminate clinical judgment