Medical-Surgical Nursing MCQs Study Guide & Practice Test Bank (Harrison’s-Based)

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. (Practice of Medicine)
A core principle emphasized in modern medical practice is that
optimal patient outcomes are best achieved through:
A. Isolated physician decision-making
B. Technology-driven care without bedside assessment
C. Integration of scientific evidence with patient values
D. Strict adherence to protocols regardless of context
Correct Answer: C
Rationale: Harrison’s emphasizes evidence-based medicine
integrated with patient preferences and clinical context.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1


2. (Promoting Good Health)
Which intervention has the greatest population-level impact on
reducing chronic disease burden?
A. Genetic screening

,B. Lifestyle modification and prevention
C. Advanced pharmacotherapy
D. Surgical intervention
Correct Answer: B
Rationale: Health promotion and prevention strategies yield the
largest public health benefit.
Citation: Harrison’s, 22nd ed., Ch. 2


3. (Vaccine Opposition and Hesitancy)
A nurse addressing vaccine hesitancy should prioritize:
A. Dismissing patient concerns
B. Providing transparent, evidence-based information
C. Emphasizing mandates over education
D. Limiting discussion to adverse effects
Correct Answer: B
Rationale: Trust-building through respectful, factual
communication is central to addressing hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3


4. (Decision-Making in Clinical Medicine)
Shared decision-making is most appropriate when:
A. Evidence strongly favors one option
B. Patient lacks decisional capacity

, C. Multiple reasonable options exist
D. Emergency intervention is required
Correct Answer: C
Rationale: Harrison’s highlights shared decision-making when
benefits and risks vary by patient values.
Citation: Harrison’s, 22nd ed., Ch. 4


5. (Precision Medicine)
Precision medicine primarily aims to:
A. Replace clinical judgment
B. Standardize all treatments
C. Tailor care based on individual variability
D. Focus solely on genetic testing
Correct Answer: C
Rationale: Precision medicine integrates genetics, environment,
and lifestyle to individualize care.
Citation: Harrison’s, 22nd ed., Ch. 5


6. (Screening and Prevention)
An effective screening test should have:
A. High cost and complexity
B. High sensitivity for early disease
C. Utility only in symptomatic patients
D. Minimal impact on outcomes