B B
ChapterB01:BCellularBBiology ...................................................................................................................................... 4
ChapterB02:BGenesBandBGeneticBDiseases .................................................................................................................. 13
ChapterB03:BEpigeneticsBandBDisease ........................................................................................................................ 23
UBSNBT O .................................................................................................................................................................... 23
ChapterB04:BAlteredBCellularBandBTissueBBiology ..................................................................................................... 27
HuetherB&BMcCance:BUnderstandingBPathophysiology,B6thBEdition ........................................................................ 39
ChapterB06:BInnateBImmunity:BInflammationBandBWoundBHealingBHuetherB&BMcCance:BUnderstandingBPathophysi
ology,B6thBEdition ...................................................................................................................................................... 48
ChapterB07:BAdaptiveBImmunity ................................................................................................................................ 60
ChapterB08:BInfectionBandBDefectsBinBMechanismsBofBDefenseBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ........................................................................................................................................................... 66
SINGTB.COM ............................................................................................................................................................... 74
ChapterB09:BStressBandBDisease ................................................................................................................................. 76
ChapterB10:BBiology,BClinicalBManifestations,BandBTreatmentBofBCancerBHuetherB&BMcCance:BUnderstandingBPath
ophysiology,B6thBEdition............................................................................................................................................ 81
ChapterB11:BCancerBEpidemiology ............................................................................................................................ 87
ChapterB12:BCancerBinBChildren................................................................................................................................. 91
ChapterB13:BStructureBandBFunctionBofBtheNeurologicBSystemBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ........................................................................................................................................................... 94
ChapterB14:BPain,BTemperature,BSleep,BandBSensoryBFunctionBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ......................................................................................................................................................... 105
ChapterB15:BAlterationsBinBCognitiveBSystems,BCerebralBHemodynamics,BandBMotorBFunction ............................ 116
ChapterB16:BDisordersBofBtheCentralBandBPeripheralBNervousBSystemsBandBtheNeuromuscularBJunction .............. 126
ChapterB17:BAlterationsBofBNeurologicBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPathophysiolog
y,B6thBEdition ........................................................................................................................................................... 138
ChapterB18:BMechanismsBofBHormonalBRegulation ................................................................................................. 147
ChapterB19:BAlterationsBofBHormonalBRegulation ................................................................................................... 156
ChapterB20:BStructureBandBFunctionBofBtheBHematologicBSystemBHuetherB&BMcCance:BUnderstandingBPathophysio
logy,B6thBEdition ...................................................................................................................................................... 169
ChapterB21:BAlterationsBofBHematologicBFunction .................................................................................................. 176
INGTB.COM ............................................................................................................................................................... 177
ChapterB22:BAlterationsBofBHematologicBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ......................................................................................................................................................... 192
ChapterB23:BStructureBandBFunctionBofBtheBCardiovascularBandBLymphaticBSystemsBHuetherB&BMcCance:BUnderst
andingBPathophysiology,B6thBEdition....................................................................................................................... 200
ChapterB24:BAlterationsBofBCardiovascularBFunction............................................................................................... 210
UBSNBT O .................................................................................................................................................................. 210
SINGTB.COM ............................................................................................................................................................. 223
UBSNBT O .................................................................................................................................................................. 226
UBSNBT O .................................................................................................................................................................. 228
ChapterB25:BAlterationsBofBCardiovascularBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPathophysio
logy,B6thBEdition ...................................................................................................................................................... 229
SBNBTB B O...................................................................................................................................................................... 232
ChapterB26:BStructureBandBFunctionBofBtheBPulmonaryBSystemBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ......................................................................................................................................................... 236
ChapterB27:BAlterationsBofBPulmonaryBFunction ..................................................................................................... 245
, ChapterB28:BAlterationsBofBPulmonaryBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPathophysiolog
y,B6thBEdition ........................................................................................................................................................... 257
ChapterB29:BStructureBandBFunctionBofBtheBRenalBandBUrologicBSystemsBHuetherB&BMcCance:BUnderstandingBPath
ophysiology,B6thBEdition ......................................................................................................................................... 265
ChapterB30:BAlterationsBofBRenalBandBUrinaryBTractBFunctionBHuetherB&BMcCance:BUnderstandingBPathophysiolo
gy,B6thBEdition ......................................................................................................................................................... 273
ChapterB31:BAlterationsBofBRenalBandBUrinaryBTractBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPa
thophysiology,B6thBEdition ...................................................................................................................................... 280
ChapterB32:BStructureBandBFunctionBofBtheBReproductiveBSystemsBHuetherB&BMcCance:BUnderstandingBPathophys
iology,B6thBEdition ................................................................................................................................................... 286
ChapterB33:BAlterationsBofBtheBFemaleBReproductiveBSystemBHuetherB&BMcCance:BUnderstandingBPathophysiolog
y,B6thBEdition ........................................................................................................................................................... 295
ChapterB34:BAlterationsBofBtheBMaleBReproductiveBSystem .................................................................................... 300
ChapterB35:BStructureBandBFunctionBofBtheBDigestiveBSystemBHuetherB&BMcCance:BUnderstandingBPathophysiolog
y,B6thBEdition ........................................................................................................................................................... 305
ChapterB36:BAlterationsBofBDigestiveBFunction........................................................................................................ 312
ChapterB37:BAlterationsBofBDigestiveBFunctionBinBChildren .................................................................................... 325
ChapterB38:BStructureBandBFunctionBofBtheBMusculoskeletalBSystemBHuetherB&BMcCance:BUnderstandingBPathoph
ysiology,B6thBEdition................................................................................................................................................ 334
UBSNBT O .................................................................................................................................................................. 337
ChapterB39:BAlterationsBofBMusculoskeletalBFunction............................................................................................. 342
ChapterB40:BAlterationsBofBMusculoskeletalBFunctionBinBChildrenBHuetherB&BMcCance:BUnderstandingBPathophysi
ology,B6thBEdition .................................................................................................................................................... 352
UBSNBT O .................................................................................................................................................................. 354
ChapterB41:BStructure,BFunction,BandBDisordersBofBtheBIntegumentBHuetherB&BMcCance:BUnderstandingBPathophys
iology,B6thBEdition ................................................................................................................................................... 357
ChapterB42:BAlterationsBofBtheBIntegumentBinBChildren .......................................................................................... 366
, Chapter 01: Cellular Biology
B B B
Huether & McCance: Understanding Pathophysiology, 6th Edition
B B B B B B
MULTIPLEBCHOICE
1. ABstudentBisBobservingBaBcellBunderBtheBmicroscope.BItBisBobservedBtoBhaveBsupercoiledBDN
ABwithBhistones.BWhichBofBtheBfollowingBwouldBalsoBbeBobservedBbyBtheBstudent?
a. ABsingleBcircularBchromosome
b. ABnucleus
c. Free-floatingBnuclearBmaterial
d. NoBorganelles
ANS:B B
TheBcellBdescribedBisBaBeukaryoticBcell,BsoBitBhasBhistonesBandBaBsupercoiledBDNABwithinBitsBn
ucleus;Bthus,BtheBnucleusBshouldBbeBobserved.BABsingleBcircularBchromosomeBcalledBaBprokary
oteBcontainsBfree-floatingBnuclearBmaterialBbutBhasBnoBorganelles.
REF:Bp.B2
2. ABnurseBisBinstructingBtheBstaffBaboutBcellularBfunctions.BWhichBcellularBfunctionBisBtheBnurse
BdescribingBwhenBanBisolatedBcellBabsorbsBoxygenBandBusesBitBtoBtransformBnutrientsBtoBenerg
y?
a. MetabolicBabsorption
b. Communication
c. Secretion
d. Respiration
ANS:BD
TheBcell’sBabilityBtoBabsorbBoxygenBisBreferredBtoBasBrespirationBwhileBitsBcommunicationBabilityBinv
olvesBmaintenanceBofBaBsteadyBdynamicBstate,BmetabolicBabsorptionBprovidesBnutrition,BandBsecretio
nBallowsBforBtheBsynthesizingBofBnewBsubstances.
REF:Bp.B2
3. ABeukaryoticBcellBisBundergoingBDNABreplication.BInBwhichBregionBofBtheBcellBwouldBmostBo
fBtheBgeneticBinformationBbeBcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusBCytoplasm
ANS:BC
TheBregionBofBtheBcellBthatBcontainsBgeneticBmaterial,BincludingBaBlargeBamountBofBribonucleicB
acid,BmostBofBtheBDNA,BandBDNA-
bindingBproteins,BisBtheBnucleolus,BwhichBisBlocatedBwithinBtheBcell’sBnucleus.BMitochondriaBis
BassociatedBwithBcellularBrespiration,BwhileBribosomesBareBinvolvedBwithBproteinBmanufacturin
g.BCytoplasmBisBaBfluidBfillingBthatBisBaBcomponentBofBtheBcell.
REF:Bp.B2