Nagelhout Pharmacology Exam 1 Review Questions With Correct Answers

Nagelhout Pharmacology Exam 1 Review Questions
With Correct Answers

Pharmacology |- |CORRECT |ANSWER✔✔-the |study |of |the |effect |of |chemicals |on |living |tissue



Pharmacokinetics |- |CORRECT |ANSWER✔✔-the |study |of |the |absorption, |distribution, |
metabolism |and |excretion |of |drugs



Pharmaceutics |- |CORRECT |ANSWER✔✔-the |formulation |and |preparation |of |drugs



pharmacoeconomics |- |CORRECT |ANSWER✔✔-the |study |of |the |economic |impact |of |drugs



toxicology |- |CORRECT |ANSWER✔✔-the |study |of |the |harmful |effects |of |chemicals



pharmacognosy |- |CORRECT |ANSWER✔✔-the |study |of |the |medicinal |uses |of |naturally |
occurring |compounds



pharmacy |- |CORRECT |ANSWER✔✔-the |preparation |and |dispensing |of |drugs



pharmacogenetics |- |CORRECT |ANSWER✔✔-genetic |influences |by |and |on |drugs



pharmacodynamics |- |CORRECT |ANSWER✔✔-physiological |and |biochemical |mechanism |of |
action |of |drugs

(e.g. |receptor |theory)



pharmacogenomics |- |CORRECT |ANSWER✔✔-identifies |discrete |genetic |differences |among |
individuals |that |play |a |critical |role |in |drug |response

,pharmacoepidemiology |- |CORRECT |ANSWER✔✔-is |the |study |of |the |use |and |effects |of |drugs |
on |large |groups |of |people



ED50 |- |CORRECT |ANSWER✔✔-Effective |dose |in |50% |of |the |population



TD50 |- |CORRECT |ANSWER✔✔-Toxic |Dose |in |50% |of |the |population



LD50 |- |CORRECT |ANSWER✔✔-Lethal |Dose |in |50% |of |the |population



Therapeutic |index |- |CORRECT |ANSWER✔✔-LD50/ED50



Therapeutic |window |- |CORRECT |ANSWER✔✔-TD50/ED50



Two |types |of |ligands |- |CORRECT |ANSWER✔✔-Agonist |or |Antagonist



Reversible |binding |of |ligands |is |called |- |CORRECT |ANSWER✔✔-competitive



non-reversible |binding |of |ligands |is |called |- |CORRECT |ANSWER✔✔-noncompetitive



5 |types |of |chemical |bonds |in |order |of |increasing |strength |- |CORRECT |ANSWER✔✔-van |der |
waals, |hydrophobic, |hydrogen, |ionic, |covalent



5 |types |of |chemical |bonds |in |order |of |decreasing |strength |- |CORRECT |ANSWER✔✔-covalent, |
ionic, |hydrogen, |hydrophobic, |van |der |waals



Occupation |of |receptors |by |ligands |is |governed |by: |- |CORRECT |ANSWER✔✔-affinity

, Activation |of |receptors |by |ligands |is |governed |by: |- |CORRECT |ANSWER✔✔-efficacy



A |dose |response |curve |can |show: |- |CORRECT |ANSWER✔✔-Affinity |(potency), |Efficacy, |
Variability, |Slope



Up |regulation |- |CORRECT |ANSWER✔✔-an |increase |in |receptor |proteins |as |a |response |to |
chronic |blockade



Down |regulation |- |CORRECT |ANSWER✔✔-Desensitization |(refractoriness) |following |continued |
stimulation |(agonists). |Chronic |beta |stimulant |use |for |asthma |resulting |in |increased |dose |
necessary |is |an |example



Drug |Interaction |- |CORRECT |ANSWER✔✔-Alteration |in |the |therapeutic |action |of |a |drug |by |
concurrent |administration |of |other |exogenous |chemicals



1+1 |= |2 |- |CORRECT |ANSWER✔✔-Addition; |The |combined |effect |of |two |drugs |acting |via |the |
same |mechanism |is |equal |to |that |expected |by |simple |addition |of |their |individual |actions

Ex) |midazolam |+ |diazepam



1+1=3 |- |CORRECT |ANSWER✔✔-synergism; |The |combined |effect |of |two |drugs |is |greater |than |
the |sum |of |their |individuals |effects

Ex) |Midazolam |+ |Propofol



1+0=3 |- |CORRECT |ANSWER✔✔-potentiation; |The |enhancement |of |the |action |of |one |drug |by |a
|second |that |has |no |detectable |action |of |its |own. |




Ex) |Penicillin |+ |probenacid