MN553 Unit 4 exam Questions with Correct Answers| Latest Update Guaranteed Success
What is the atopic triad Asthma
Atopic dermatitis
Allergic rhinitis
Initial asthma treatment Bronchodilators
-SABA
Examples of SABAs Albuterol
Levalbuterol
SABA MOA SABAs work on the smooth muscles of the lungs. SABAs target a receptor called
the beta-2 receptor in the airways. The drug activates the beta-2 receptor, and this helps relax
the muscles in the airway. As a result, breathing improves
Bronchodilation
Step up after bronchodilator use ICS
LABA
Leukotriene antagonists
What is used for acute asthma exacerbations IV corticosteroids
,Magnesium sulfate
Oxygen
Asthma treatment includes •Inhaled steroids
•Short-acting beta agonists (SABAs)
•Long-acting beta agonists (LABAs)
•Long-acting muscarinic antagonists (LAMAs)
•Leukotriene receptor antagonists (LTRAs)
•Theophylline
•Asthma biologics
•Immunotherapy
Examples of ICS Ciclesonide (Alvesco)
Budesonide (Plmicort
Beclomethasone dipropionate (Qvar)
ICS MOA Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They
suppress inflammation mainly by switching off multiple activated inflammatory genes through
reversing histone acetylation via the recruitment of histone deacetylase 2 (HDAC2).
Examples of LABAs •Advair (fluticasone propionate/salmeterol)
•Dulera (mometasone/formoterol fumarate)
•Symbicort (budesonide/formoterol fumarate)
•Breo (fluticasone furoate/vilanterol)
,Examples of Leukotriene receptor antagonists (LTRAs) •Singulair (montelukast)
•Accolate (zafirlukast)
•Zyflo (zileuton)
LABA MOA highly specific agonist for Beta2 receptors with a prolonged duration of action
(12 hours)
Inhibit mast cell mediator release, plasma exudation and may reduce sensory nerve activation.
Relax airway smooth muscle by stimulating beta2-adrenergic receptors, which increases cyclic
AMP and antagonizes mechanisms of bronchoconstriction.
LTRA MOA inhibit leukotriene mediators of airway inflammation
Block the effects of cysteinyl leukotrienes in the airways—these leukotrienes are released
during asthma flare-ups and cause bronchoconstriction
Biologics for asthma •Xolair (omalizumab)
•Nucala (mepolizumab)
•Cinqair (reslizumab)
•Fasenra (benralizumab)
•Dupixent (dupilumab)
Classifications of asthma Mild persistent
Moderate persistent
Severe persistent
, True or false
Asthma slightly differs definitions for adults and children True
Goals of asthma therapy Reduce impairment
Prevent chronic symptoms
True or false
Asthma is over diagnosed False
Differential diagnosis for asthma TB
HIV/AIDS associated lung disease
Parasitic or fungal lung diseases
What type of approach is used for asthma diagnosis Syndromic approach
Before commencing long term treatment for asthma was does GINA recommend
Conformation of diagnosis with PFTs
Diagnostic criteria for PEF •>20% increase in PEF, 15 minutes after 2 puffs of salbutamol =
asthma likely (WHO-PEN)
•Improvement of symptoms and PEF after 4 weeks ICS treatment
What is the atopic triad Asthma
Atopic dermatitis
Allergic rhinitis
Initial asthma treatment Bronchodilators
-SABA
Examples of SABAs Albuterol
Levalbuterol
SABA MOA SABAs work on the smooth muscles of the lungs. SABAs target a receptor called
the beta-2 receptor in the airways. The drug activates the beta-2 receptor, and this helps relax
the muscles in the airway. As a result, breathing improves
Bronchodilation
Step up after bronchodilator use ICS
LABA
Leukotriene antagonists
What is used for acute asthma exacerbations IV corticosteroids
,Magnesium sulfate
Oxygen
Asthma treatment includes •Inhaled steroids
•Short-acting beta agonists (SABAs)
•Long-acting beta agonists (LABAs)
•Long-acting muscarinic antagonists (LAMAs)
•Leukotriene receptor antagonists (LTRAs)
•Theophylline
•Asthma biologics
•Immunotherapy
Examples of ICS Ciclesonide (Alvesco)
Budesonide (Plmicort
Beclomethasone dipropionate (Qvar)
ICS MOA Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They
suppress inflammation mainly by switching off multiple activated inflammatory genes through
reversing histone acetylation via the recruitment of histone deacetylase 2 (HDAC2).
Examples of LABAs •Advair (fluticasone propionate/salmeterol)
•Dulera (mometasone/formoterol fumarate)
•Symbicort (budesonide/formoterol fumarate)
•Breo (fluticasone furoate/vilanterol)
,Examples of Leukotriene receptor antagonists (LTRAs) •Singulair (montelukast)
•Accolate (zafirlukast)
•Zyflo (zileuton)
LABA MOA highly specific agonist for Beta2 receptors with a prolonged duration of action
(12 hours)
Inhibit mast cell mediator release, plasma exudation and may reduce sensory nerve activation.
Relax airway smooth muscle by stimulating beta2-adrenergic receptors, which increases cyclic
AMP and antagonizes mechanisms of bronchoconstriction.
LTRA MOA inhibit leukotriene mediators of airway inflammation
Block the effects of cysteinyl leukotrienes in the airways—these leukotrienes are released
during asthma flare-ups and cause bronchoconstriction
Biologics for asthma •Xolair (omalizumab)
•Nucala (mepolizumab)
•Cinqair (reslizumab)
•Fasenra (benralizumab)
•Dupixent (dupilumab)
Classifications of asthma Mild persistent
Moderate persistent
Severe persistent
, True or false
Asthma slightly differs definitions for adults and children True
Goals of asthma therapy Reduce impairment
Prevent chronic symptoms
True or false
Asthma is over diagnosed False
Differential diagnosis for asthma TB
HIV/AIDS associated lung disease
Parasitic or fungal lung diseases
What type of approach is used for asthma diagnosis Syndromic approach
Before commencing long term treatment for asthma was does GINA recommend
Conformation of diagnosis with PFTs
Diagnostic criteria for PEF •>20% increase in PEF, 15 minutes after 2 puffs of salbutamol =
asthma likely (WHO-PEN)
•Improvement of symptoms and PEF after 4 weeks ICS treatment
