FA-BA304
Oncologie
Samenvatting colleges
Michelle
,Inhoud
Dikke darmkanker .................................................................................................................................... 5
Algemene beschrijving dikke darmkanker........................................................................................................ 5
Subtypes dikke darmkanker ............................................................................................................................. 7
Vogel-gram ....................................................................................................................................................... 7
Besproken mutaties .......................................................................................................................................... 9
K-RAS mutatie ............................................................................................................................................... 9
B-RAF mutatie............................................................................................................................................... 9
Medicatie .......................................................................................................................................................... 9
Casus ............................................................................................................................................................... 10
Extra leerpunten uit de casus ..................................................................................................................... 11
Subtypering van kanker in het algemeen ................................................................................................... 11
Borstkanker ........................................................................................................................................... 12
Algemene beschrijving borstkanker ............................................................................................................... 12
Subtypen borstkanker .................................................................................................................................... 13
DNA reparatie systemen................................................................................................................................. 15
BRCA mutatie .................................................................................................................................................. 16
Medicatie ........................................................................................................................................................ 16
Casus ............................................................................................................................................................... 19
Huidkanker; melanoom .......................................................................................................................... 21
Algemene beschrijving melanoom ................................................................................................................. 21
Subtypen huidkanker ...................................................................................................................................... 22
Melanoom karakterisering ............................................................................................................................. 22
Besproken mutaties ........................................................................................................................................ 25
K-RAS mutatie ............................................................................................................................................. 25
B-RAF mutatie............................................................................................................................................. 25
KIT mutatie ................................................................................................................................................. 25
NF1 mutatie ................................................................................................................................................ 25
PTEN mutatie .............................................................................................................................................. 25
Medicatie ........................................................................................................................................................ 26
Casus ............................................................................................................................................................... 28
Eierstokkanker ....................................................................................................................................... 30
Algemene beschrijving.................................................................................................................................... 30
Michelle
2
, Subgroepen eierstokkanker............................................................................................................................ 30
Checkpoints .................................................................................................................................................... 30
G1-checkpoint ............................................................................................................................................ 30
G2-checkpoint ............................................................................................................................................ 31
M-checkpoint.............................................................................................................................................. 31
Medicatie ........................................................................................................................................................ 32
Casus ............................................................................................................................................................... 34
Resistentie ...................................................................................................................................................... 34
Longkanker; casus bespreking ................................................................................................................ 35
Longkanker algemeen..................................................................................................................................... 35
Symptomen van longkanker ....................................................................................................................... 35
Risicofactoren bij longkanker ..................................................................................................................... 35
Soorten longkanker .................................................................................................................................... 35
Stadia van longkanker ................................................................................................................................ 35
Levensverwachting bij longkanker ............................................................................................................. 36
Casus ............................................................................................................................................................... 36
Medicatie ........................................................................................................................................................ 38
Prostaatkanker; journalclub ................................................................................................................... 40
Prostaatkanker algemeen ............................................................................................................................... 40
Risicofactoren ............................................................................................................................................. 40
Levensverwachting ..................................................................................................................................... 40
Kaplan Meier curve ......................................................................................................................................... 40
Journal club..................................................................................................................................................... 40
Farmacokinetiek .................................................................................................................................... 42
Nanomedicijnen en advanced therapies in de oncologie .......................................................................... 43
Medicatie overzicht................................................................................................................................ 44
Alkylerende middelen ..................................................................................................................................... 44
Alkylsulfonderivaten ................................................................................................................................... 44
Oxazafosforinen.......................................................................................................................................... 44
Stikstofmosterderivaten ............................................................................................................................. 45
Overige alkylerende stoffen ....................................................................................................................... 45
Antimetabolieten............................................................................................................................................ 45
Foliumzuurantagonisten............................................................................................................................. 45
Michelle
3
, Purinederivaten .......................................................................................................................................... 46
Pyrimidine-antagonisten ............................................................................................................................ 47
Cytostatische antibiotica ................................................................................................................................ 48
Antracyclinederivaten ................................................................................................................................ 48
Overige cytostatiche antibiotica ................................................................................................................. 49
Antimitotische stoffen .................................................................................................................................... 49
Vinca-alkaloïden ......................................................................................................................................... 49
Taxanen ...................................................................................................................................................... 49
Topo-isomeraseremmers ............................................................................................................................... 50
Topo-isomerase-I remmers ........................................................................................................................ 50
Topo-isomerase-II remmers ....................................................................................................................... 50
Platinaverbindingen........................................................................................................................................ 50
Signaaltransductieremmers............................................................................................................................ 51
Monoklonale antilichamen......................................................................................................................... 51
Tyrosinekinase remmers ............................................................................................................................ 52
Overige signaaltransductieremmers .......................................................................................................... 52
Antihormonen ................................................................................................................................................ 52
Anti-androgenen ........................................................................................................................................ 52
Anti-oestrogenen........................................................................................................................................ 53
Aromataseremmers.................................................................................................................................... 53
Overige nieuwe oncolytica ............................................................................................................................. 53
PARP-inhibitors ........................................................................................................................................... 53
Checkpoint inhibitors overig....................................................................................................................... 53
Michelle
4
Oncologie
Samenvatting colleges
Michelle
,Inhoud
Dikke darmkanker .................................................................................................................................... 5
Algemene beschrijving dikke darmkanker........................................................................................................ 5
Subtypes dikke darmkanker ............................................................................................................................. 7
Vogel-gram ....................................................................................................................................................... 7
Besproken mutaties .......................................................................................................................................... 9
K-RAS mutatie ............................................................................................................................................... 9
B-RAF mutatie............................................................................................................................................... 9
Medicatie .......................................................................................................................................................... 9
Casus ............................................................................................................................................................... 10
Extra leerpunten uit de casus ..................................................................................................................... 11
Subtypering van kanker in het algemeen ................................................................................................... 11
Borstkanker ........................................................................................................................................... 12
Algemene beschrijving borstkanker ............................................................................................................... 12
Subtypen borstkanker .................................................................................................................................... 13
DNA reparatie systemen................................................................................................................................. 15
BRCA mutatie .................................................................................................................................................. 16
Medicatie ........................................................................................................................................................ 16
Casus ............................................................................................................................................................... 19
Huidkanker; melanoom .......................................................................................................................... 21
Algemene beschrijving melanoom ................................................................................................................. 21
Subtypen huidkanker ...................................................................................................................................... 22
Melanoom karakterisering ............................................................................................................................. 22
Besproken mutaties ........................................................................................................................................ 25
K-RAS mutatie ............................................................................................................................................. 25
B-RAF mutatie............................................................................................................................................. 25
KIT mutatie ................................................................................................................................................. 25
NF1 mutatie ................................................................................................................................................ 25
PTEN mutatie .............................................................................................................................................. 25
Medicatie ........................................................................................................................................................ 26
Casus ............................................................................................................................................................... 28
Eierstokkanker ....................................................................................................................................... 30
Algemene beschrijving.................................................................................................................................... 30
Michelle
2
, Subgroepen eierstokkanker............................................................................................................................ 30
Checkpoints .................................................................................................................................................... 30
G1-checkpoint ............................................................................................................................................ 30
G2-checkpoint ............................................................................................................................................ 31
M-checkpoint.............................................................................................................................................. 31
Medicatie ........................................................................................................................................................ 32
Casus ............................................................................................................................................................... 34
Resistentie ...................................................................................................................................................... 34
Longkanker; casus bespreking ................................................................................................................ 35
Longkanker algemeen..................................................................................................................................... 35
Symptomen van longkanker ....................................................................................................................... 35
Risicofactoren bij longkanker ..................................................................................................................... 35
Soorten longkanker .................................................................................................................................... 35
Stadia van longkanker ................................................................................................................................ 35
Levensverwachting bij longkanker ............................................................................................................. 36
Casus ............................................................................................................................................................... 36
Medicatie ........................................................................................................................................................ 38
Prostaatkanker; journalclub ................................................................................................................... 40
Prostaatkanker algemeen ............................................................................................................................... 40
Risicofactoren ............................................................................................................................................. 40
Levensverwachting ..................................................................................................................................... 40
Kaplan Meier curve ......................................................................................................................................... 40
Journal club..................................................................................................................................................... 40
Farmacokinetiek .................................................................................................................................... 42
Nanomedicijnen en advanced therapies in de oncologie .......................................................................... 43
Medicatie overzicht................................................................................................................................ 44
Alkylerende middelen ..................................................................................................................................... 44
Alkylsulfonderivaten ................................................................................................................................... 44
Oxazafosforinen.......................................................................................................................................... 44
Stikstofmosterderivaten ............................................................................................................................. 45
Overige alkylerende stoffen ....................................................................................................................... 45
Antimetabolieten............................................................................................................................................ 45
Foliumzuurantagonisten............................................................................................................................. 45
Michelle
3
, Purinederivaten .......................................................................................................................................... 46
Pyrimidine-antagonisten ............................................................................................................................ 47
Cytostatische antibiotica ................................................................................................................................ 48
Antracyclinederivaten ................................................................................................................................ 48
Overige cytostatiche antibiotica ................................................................................................................. 49
Antimitotische stoffen .................................................................................................................................... 49
Vinca-alkaloïden ......................................................................................................................................... 49
Taxanen ...................................................................................................................................................... 49
Topo-isomeraseremmers ............................................................................................................................... 50
Topo-isomerase-I remmers ........................................................................................................................ 50
Topo-isomerase-II remmers ....................................................................................................................... 50
Platinaverbindingen........................................................................................................................................ 50
Signaaltransductieremmers............................................................................................................................ 51
Monoklonale antilichamen......................................................................................................................... 51
Tyrosinekinase remmers ............................................................................................................................ 52
Overige signaaltransductieremmers .......................................................................................................... 52
Antihormonen ................................................................................................................................................ 52
Anti-androgenen ........................................................................................................................................ 52
Anti-oestrogenen........................................................................................................................................ 53
Aromataseremmers.................................................................................................................................... 53
Overige nieuwe oncolytica ............................................................................................................................. 53
PARP-inhibitors ........................................................................................................................................... 53
Checkpoint inhibitors overig....................................................................................................................... 53
Michelle
4
