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2026 RN Pharmacology Exam Prep: High-Yield Concepts & Practice Questions for A+ Performance

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2026 RN Pharmacology Exam Prep: High-Yield Concepts & Practice Questions for A+ Performance Prepare effectively for the 2026 RN Pharmacology A exam with this updated study guide, covering essential drug classes, mechanisms, side effects, and nursing considerations. The guide provides representative practice questions with detailed rationales to strengthen understanding and clinical judgment. Focused on safe medication administration and pharmacologic principles, it supports BSN, ADN, and RN-to-BSN students in building confidence. This structured approach ensures retention of high-yield content and readiness for assessment checkpoints. Use evidence-based strategies, clinical scenarios, and practice items to maximize performance and achieve top grades.

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RN Pharmacology A Relias (NEW UPDATED VERSION) LATEST ACTUAL EXAM
QUESTIONS AND CORRECT ANSWERS (VERIFIED QUESTIONS AND ANSWERS)-
GUARANTEED PASS A+ UPDATED 2025




RN Pharmacology Questions

Cardiovascular Drugs

1. A patient is prescribed lisinopril. Which lab should the nurse monitor?
A) Sodium
B) Potassium
C) Calcium
D) Magnesium
Answer: B
Rationale: ACE inhibitors can cause hyperkalemia, so potassium levels should be
monitored regularly.
2. Furosemide is prescribed. Which electrolyte imbalance is likely?
A) Hyperkalemia
B) Hypokalemia
C) Hypercalcemia
D) Hypernatremia
Answer: B
Rationale: Loop diuretics increase potassium excretion, risking hypokalemia.
3. Nitroglycerin instructions should include:
A) Take only when resting
B) Take at first sign of chest pain
C) Take with grapefruit juice
D) Avoid position changes
Answer: B
Rationale: Nitroglycerin should be taken at the onset of chest pain for relief.
4. Atorvastatin works by:
A) Increasing cholesterol absorption
B) Inhibiting HMG-CoA reductase
C) Acting as a diuretic
D) Increasing BP
Answer: B
Rationale: Statins inhibit HMG-CoA reductase, reducing cholesterol production.



2026 2027 GRADED A+

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5. Signs of digoxin toxicity include:
A) Bradycardia, visual changes
B) Tachycardia, hyperactivity
C) Hypertension only
D) Nausea, hypokalemia
Answer: A
Rationale: Digoxin toxicity causes bradycardia, nausea, and yellow/green vision
changes.
6. A patient receiving metoprolol should have which vital monitored?
A) Temperature
B) Heart rate
C) Respiratory rate
D) Oxygen saturation
Answer: B
Rationale: Beta-blockers reduce heart rate; bradycardia is a risk.
7. Enalapril may cause:
A) Dry cough
B) Tachycardia
C) Diarrhea
D) Hair loss
Answer: A
Rationale: ACE inhibitors commonly cause a persistent dry cough.
8. Hydrochlorothiazide is prescribed. What is important to monitor?
A) Sodium and potassium
B) Liver enzymes
C) WBC count
D) Glucose only
Answer: A
Rationale: Thiazide diuretics can cause hypokalemia and hyponatremia.
9. Amlodipine is used for:
A) Arrhythmias
B) Hypertension
C) Hyperlipidemia
D) Heart failure
Answer: B
Rationale: Amlodipine is a calcium channel blocker that lowers BP.
10. A patient on warfarin asks about diet. Which statement is correct?
A) Avoid foods high in vitamin K
B) Increase intake of dairy
C) Eat more citrus
D) Avoid all carbohydrates
Answer: A
Rationale: Vitamin K can counteract warfarin’s anticoagulant effect.




2026 2027 GRADED A+

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Central Nervous System Drugs

11. Lorazepam may cause:
A) Hypertension
B) Respiratory depression
C) Tachycardia
D) Insomnia
Answer: B
Rationale: Benzodiazepines depress CNS and respiratory function.
12. Fluoxetine teaching should include:
A) Take with grapefruit juice
B) Expect sexual side effects
C) Avoid all fats
D) Monitor sodium only
Answer: B
Rationale: SSRIs commonly cause sexual dysfunction.
13. Phenytoin side effect:
A) Gingival hyperplasia
B) Cough
C) Weight gain
D) Hypertension
Answer: A
Rationale: Long-term phenytoin therapy can cause gum overgrowth.
14. Phenobarbital therapy requires monitoring:
A) Liver function
B) Renal function
C) Cardiac enzymes
D) Glucose
Answer: A
Rationale: Barbiturates are metabolized in the liver and may cause hepatotoxicity.
15. Levodopa-carbidopa is prescribed for:
A) Parkinson’s disease
B) Alzheimer’s disease
C) Anxiety
D) Epilepsy
Answer: A
Rationale: Levodopa replenishes dopamine to reduce Parkinsonian symptoms.
16. Sumatriptan is used for:
A) Hypertension
B) Migraine
C) Heart failure
D) Seizures
Answer: B
Rationale: Sumatriptan is a serotonin agonist that relieves migraine.
17. Carbamazepine teaching includes:
A) Avoid grapefruit juice


2026 2027 GRADED A+

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