ASCP HEMATOLOGY END OF COURSE EXAM QUESTIONS
AND ANSWERS GRADED A+
✔✔Hyposegmented neutrophils are associated with - ✔✔pelger huet anomaly (AML,
AIDS)
✔✔Toxic granulation and vacuoles are associated with - ✔✔bacterial infection, burns,
chemo
✔✔Dhole bodies are associated with - ✔✔bacterial infections, burns, may hegglin
anomaly
✔✔Variant lymphs are associated with - ✔✔IM, viral infection
✔✔What is the calculation for a corrected white count when nucleolar reds are seen? -
✔✔(WBC x 100/ 100 +nrbc)
✔✔What RBC inclusion is NOT seen with wright stain? - ✔✔Heinz bodies
✔✔Where is blood produced at 1 month? - ✔✔yolk sac
✔✔Where is blood produced at 4 months? - ✔✔spleen and liver
✔✔Where is blood produced at 8 months? - ✔✔bone marrow
✔✔What hemoglobin chains make up A2? - ✔✔alpha, delta
✔✔What hemoglobin chins make up A? - ✔✔alpha, beta
✔✔What hemoglobin chains make up F? - ✔✔alpha, gamma
✔✔What hemoglobin chains make up portland? - ✔✔zeta, gamma
✔✔What hemoglobin chains make up gower 2? - ✔✔alpha, epsilon
✔✔What hemoglobin chains make up gower? - ✔✔zeta, epsilon
✔✔Howell-Joly bodies are composed of - ✔✔DNA
✔✔Basophilic stippling is composed of - ✔✔RNA
✔✔Pappenheimer bodies/siderotic granules are composed of - ✔✔Iron
, ✔✔Heinz bodies are composed of - ✔✔denatured hemoglobin
✔✔What inclusion? Disturbed erythropoiesis, hemolytic anemias, megaloblastic
anemia, post-splenectomy - ✔✔howel jolly bodies
✔✔What inclusion? Thalassemia, lead poisoning - ✔✔Basophilic stippling
✔✔What inclusion? Hemoglobinopathies - ✔✔pappenheimer bodies/siderotic granules
✔✔What inclusion? G6PD deficiency, thalassemia, unstable hemoglobins - ✔✔heinz
bodies
✔✔H2O insoluble Fe storage form (long-term) - ✔✔hemosiderin
✔✔Heparin is an ______________________ - ✔✔anti-thrombin agent
✔✔What is the only hemoglobin not measured by cyanmethemoglobin methods? -
✔✔sulfhemoglobin
✔✔Clinical correlations: dry tap may mean - ✔✔aplastic anemia, myelofibrosis
✔✔What is the usual M:E ratio? - ✔✔3:1 or 4:1
✔✔What should the ratio of cells to fat be in the bone marrow? - ✔✔50%:50%
✔✔What hemoglobin is caused by this mutation? Valine for Glutamic Acid (6th position
beta chain) - ✔✔S
✔✔What hemoglobin is caused by this mutation? Lysine for Glutamic Acid (6th position
beta chain) - ✔✔C
✔✔What thalassemia? decreased or absent production of beta chains - ✔✔beta
thalassemia
✔✔What thalassemia? increase in HB A2, Increase in Hb F, decrease or absent Hb A -
✔✔beta thalassemia
✔✔What thalassemia? decreased production of alpha chains - ✔✔alpha thalassemia
✔✔What is the silent carrier genotype for alpha thalassemia - ✔✔(-a/aa)
✔✔What is the mild microcytic or hypochromic anemia genotype in alpha thalassemia?
- ✔✔(--/aa) or (-a/-a)
AND ANSWERS GRADED A+
✔✔Hyposegmented neutrophils are associated with - ✔✔pelger huet anomaly (AML,
AIDS)
✔✔Toxic granulation and vacuoles are associated with - ✔✔bacterial infection, burns,
chemo
✔✔Dhole bodies are associated with - ✔✔bacterial infections, burns, may hegglin
anomaly
✔✔Variant lymphs are associated with - ✔✔IM, viral infection
✔✔What is the calculation for a corrected white count when nucleolar reds are seen? -
✔✔(WBC x 100/ 100 +nrbc)
✔✔What RBC inclusion is NOT seen with wright stain? - ✔✔Heinz bodies
✔✔Where is blood produced at 1 month? - ✔✔yolk sac
✔✔Where is blood produced at 4 months? - ✔✔spleen and liver
✔✔Where is blood produced at 8 months? - ✔✔bone marrow
✔✔What hemoglobin chains make up A2? - ✔✔alpha, delta
✔✔What hemoglobin chins make up A? - ✔✔alpha, beta
✔✔What hemoglobin chains make up F? - ✔✔alpha, gamma
✔✔What hemoglobin chains make up portland? - ✔✔zeta, gamma
✔✔What hemoglobin chains make up gower 2? - ✔✔alpha, epsilon
✔✔What hemoglobin chains make up gower? - ✔✔zeta, epsilon
✔✔Howell-Joly bodies are composed of - ✔✔DNA
✔✔Basophilic stippling is composed of - ✔✔RNA
✔✔Pappenheimer bodies/siderotic granules are composed of - ✔✔Iron
, ✔✔Heinz bodies are composed of - ✔✔denatured hemoglobin
✔✔What inclusion? Disturbed erythropoiesis, hemolytic anemias, megaloblastic
anemia, post-splenectomy - ✔✔howel jolly bodies
✔✔What inclusion? Thalassemia, lead poisoning - ✔✔Basophilic stippling
✔✔What inclusion? Hemoglobinopathies - ✔✔pappenheimer bodies/siderotic granules
✔✔What inclusion? G6PD deficiency, thalassemia, unstable hemoglobins - ✔✔heinz
bodies
✔✔H2O insoluble Fe storage form (long-term) - ✔✔hemosiderin
✔✔Heparin is an ______________________ - ✔✔anti-thrombin agent
✔✔What is the only hemoglobin not measured by cyanmethemoglobin methods? -
✔✔sulfhemoglobin
✔✔Clinical correlations: dry tap may mean - ✔✔aplastic anemia, myelofibrosis
✔✔What is the usual M:E ratio? - ✔✔3:1 or 4:1
✔✔What should the ratio of cells to fat be in the bone marrow? - ✔✔50%:50%
✔✔What hemoglobin is caused by this mutation? Valine for Glutamic Acid (6th position
beta chain) - ✔✔S
✔✔What hemoglobin is caused by this mutation? Lysine for Glutamic Acid (6th position
beta chain) - ✔✔C
✔✔What thalassemia? decreased or absent production of beta chains - ✔✔beta
thalassemia
✔✔What thalassemia? increase in HB A2, Increase in Hb F, decrease or absent Hb A -
✔✔beta thalassemia
✔✔What thalassemia? decreased production of alpha chains - ✔✔alpha thalassemia
✔✔What is the silent carrier genotype for alpha thalassemia - ✔✔(-a/aa)
✔✔What is the mild microcytic or hypochromic anemia genotype in alpha thalassemia?
- ✔✔(--/aa) or (-a/-a)
