ANCC PRACTICE QUESTIONS DOMAIN 1
WITH CORRECT ANSWERS 2026
As a PMHNP, you are aware of antipsychotic medication side effects. Which of the following side
effects of antipsychotic medications has an insidious, delayed-onset typically 1 to 2 years after
initiation of the medication?
a. Dry mouth
b. Tardive dyskinesia
c. Sedation
d. Weight gain - CORRECT ANSWER -B
In evaluating a 4-year-old, one would expect which of the following delays in Asperger's
Disorder?
a. Language development
b. Cognitive development
c. Motor skills coordination
d. Social skills development - CORRECT ANSWER -D
Which area of the brain has been implicated to modulate pain and can help explain how
transcranial magnetic stimulation can help decrease pain?
a. Prefrontal cortex
b. Insula cortex
c. Dorsolateral prefrontal cortex
d. Anterior cingulate cortex - CORRECT ANSWER -A
Which of the following antidepressants is associated with dose-related cardiovascular adverse
effects which require adherence to maximum recommended dosing, unless higher doses are
deemed appropriate despite risks?
, a. Citalopram (Celexa)
b. Venlafaxine (Effexor)
c. Mirtazapine (Remeron)
d. Sertraline (Zoloft) - CORRECT ANSWER -A
Which of the following findings would raise concern in an annual sports exam for a 15-year-old
girl?
a. Scar tissue from hymenal tear at 11 o'clock (reported biking injury)
b. Blood pressure 86/56
c. Height 67 inches, weight 102 pounds
d. Pulse 60, respirations 26 - CORRECT ANSWER -C
A week after raising the dose of risperidone (Risperdal), a patient treated for schizophrenia
presents to the clinic with reports of an acute change in mental status, fever, and rigidity. As the
treating PMHNP, you know these symptoms are consistent with which of the following?
a. Neuroleptic malignant syndrome (NMS)
b. Anticholinergic withdrawal syndrome
c. Extrapyramidal side effects
d. Serotonin syndrome - CORRECT ANSWER -A
Which of the following statements regarding disulfiram (Antabuse is correct?
a. Disulfiram should not be taken for at least 6 hours after drinking alcohol.
b. Avoid anything containing alcohol (i.e., vinegar, mouthwash, aftershave, cough medication)
while using disulfiram and for 2 weeks after discontinuing.
c. A disulfiram-alcohol reaction can occur up to 1 week after discontinuing disulfiram.
d. Disulfiram can lower liver function tests so monitoring is necessary. - CORRECT ANSWER -B
WITH CORRECT ANSWERS 2026
As a PMHNP, you are aware of antipsychotic medication side effects. Which of the following side
effects of antipsychotic medications has an insidious, delayed-onset typically 1 to 2 years after
initiation of the medication?
a. Dry mouth
b. Tardive dyskinesia
c. Sedation
d. Weight gain - CORRECT ANSWER -B
In evaluating a 4-year-old, one would expect which of the following delays in Asperger's
Disorder?
a. Language development
b. Cognitive development
c. Motor skills coordination
d. Social skills development - CORRECT ANSWER -D
Which area of the brain has been implicated to modulate pain and can help explain how
transcranial magnetic stimulation can help decrease pain?
a. Prefrontal cortex
b. Insula cortex
c. Dorsolateral prefrontal cortex
d. Anterior cingulate cortex - CORRECT ANSWER -A
Which of the following antidepressants is associated with dose-related cardiovascular adverse
effects which require adherence to maximum recommended dosing, unless higher doses are
deemed appropriate despite risks?
, a. Citalopram (Celexa)
b. Venlafaxine (Effexor)
c. Mirtazapine (Remeron)
d. Sertraline (Zoloft) - CORRECT ANSWER -A
Which of the following findings would raise concern in an annual sports exam for a 15-year-old
girl?
a. Scar tissue from hymenal tear at 11 o'clock (reported biking injury)
b. Blood pressure 86/56
c. Height 67 inches, weight 102 pounds
d. Pulse 60, respirations 26 - CORRECT ANSWER -C
A week after raising the dose of risperidone (Risperdal), a patient treated for schizophrenia
presents to the clinic with reports of an acute change in mental status, fever, and rigidity. As the
treating PMHNP, you know these symptoms are consistent with which of the following?
a. Neuroleptic malignant syndrome (NMS)
b. Anticholinergic withdrawal syndrome
c. Extrapyramidal side effects
d. Serotonin syndrome - CORRECT ANSWER -A
Which of the following statements regarding disulfiram (Antabuse is correct?
a. Disulfiram should not be taken for at least 6 hours after drinking alcohol.
b. Avoid anything containing alcohol (i.e., vinegar, mouthwash, aftershave, cough medication)
while using disulfiram and for 2 weeks after discontinuing.
c. A disulfiram-alcohol reaction can occur up to 1 week after discontinuing disulfiram.
d. Disulfiram can lower liver function tests so monitoring is necessary. - CORRECT ANSWER -B
