NURS 5357 NEUROBIOLOGY CORE EXAM TEST
QUESTIONS AND SOLUTIONS RATED A+
✔✔2. Which pathway is believed to result in the negative symptoms of schizophrenia?
a. Nigrostriatal. b. Mesocortical. c. Mesolimbic. d. Tuberoinfundibular. - ✔✔b.
Mesocortical.
✔✔3. Which pathway mediates prolactin? a. Nigrostriatal. b. Mesocortical. c.
Mesolimbic. d. Tuberoinfundibular. - ✔✔d. Tuberoinfundibular.
✔✔4. The cell bodies of the NE neurons are located in the locus coeruleus and the a.
Medullary reticular formation. b. Raphe nuclei. c. Arcuate nucleus. d. Tuberomammillary
nucleus. - ✔✔a. Medullary reticular formation.
✔✔5. Most of the cell bodies for histamine neurons reside in the a. Medullary reticular
formation. b. Raphe nuclei. c. Arcuate nucleus. d. Tuberomammillary nucleus. -
✔✔Tuberomammillary nucleus
✔✔6. Which statement is not true regarding NO? a. It is quickly degraded. b. It converts
GTP into cGMP. c. It is stored in dense core vesicles. d. It is formed from arginine. -
✔✔c. It is stored in dense core vesicles
✔✔7. All of the following are neuropeptides except a. Cannabinoid peptides. b. Pituitary
peptides. c. Opioid peptides. d. Hypothalamic releasing peptides. - ✔✔a. Cannabinoid
peptides.
✔✔8. The most common neurotransmitter in the brain is a. Serotonin. b. Dopamine. c.
γ-Aminobutyric acid. d. Glutamate. - ✔✔d. Glutamate.
✔✔1. Which equation is correct? a. Antagonist = stimulate. b. Agonist = block. c.
Agonist = transmitter. d. Antagonist = endogenous ligand. - ✔✔Agonist = transmitter
✔✔2. Which is not a glutamate receptor? a. NMDA. b. cAMP. c. AMPA. d. Kainate. -
✔✔b. cAMP
✔✔3. The strength of the GABA inhibitory signal is enhanced by all of the following
except a. Ethanol. b. Phenobarbital. c. Carbamazepine. d. Neurosteroids. - ✔✔c.
Carbamazepine
✔✔4. The AEDs exert their major effects through all of the following except a.
Decreasing glutamate activity. b. Modulation of the voltage-gated sodium channels. c.
Blockade of the voltage-gated calcium channels. d. Increasing GABA activity. -
✔✔Decreasing glutamate activity
, ✔✔5. Which of the following is true? a. Mg2+ is a common secondary messenger. b.
Most monoamine receptors are fast receptors. c. Fast receptors typically lead to gene
expression. d. Autoreceptors give negative feedback to the neuron. - ✔✔d.
Autoreceptors give negative feedback to the neuron.
✔✔6. Gene expression stimulated by a neurotransmitter involves all of the following
except a. Phosphorylation. b. Long-term potentiation. c. Protein kinases. d. G protein-
coupled receptor. - ✔✔b. Long-term potentiation
✔✔7. All of the following about LTP are true except a. Enhanced EPSP. b. Increased
receptors. c. Gene expression. d. Enhanced ligand binding. - ✔✔d. Enhanced ligand
binding
✔✔8. Which describes LTP best? a. It was discovered by accident. b. Neuroscientists
love to pontificate on this topic. c. It is an example of learning. d. All of the above - ✔✔d.
All of the above
✔✔1. Why does the governor of South Carolina have so few protein-coding genes? a.
The governor believes protein-coding genes are another example of too much
government control. b. The governor is closely related to Caenorhabditis elegans. c.
The governor sold off the vast majority of protein-coding genes in an attempt to balance
the State budget. d. Because much of the complexity of the human species is controlled
by other parts of the DNA. - ✔✔Because much of the complexity of the human species
is controlled by other parts of the DNA.
✔✔2. All of the following lead us to believe "junk DNA" is important except a. Non-
protein-coding sections are highly expressed in the brain . b. RNA has more capacity to
control functions in a cell than previously recognized. c. Defects in "junk DNA" have
been identified in autism. d. Some microRNAs have been implicated in schizophrenia. -
✔✔Defects in "junk DNA" have been identified in autism
✔✔3. What has happened to the "chemical imbalance" theories of mental illness in the
genomic era? a. Genome-wide studies fail to implicate genes that are associated with
neurotransmitters or their receptors. b. Genes for the serotonin receptor have been
identified in families with bipolar disorder in multiple linkage studies. c. The dopamine
transporter gene on chromosome 11 is altered in most patients with childhood-onset
schizophrenia. d. A significant number of patients with panic disorder are lacking the
gene for the A section of the GABA receptor. - ✔✔Genome-wide studies fail to implicate
genes that are associated with neurotransmitters or their receptors.
✔✔4. Understanding epigenetics helps us understand a. Why non-protein-coding
sections are so highly expressed in the brain. b. How events in the environment can
alter gene expression. c. The cognitive effects of trisomy 21. d. The increased potential
QUESTIONS AND SOLUTIONS RATED A+
✔✔2. Which pathway is believed to result in the negative symptoms of schizophrenia?
a. Nigrostriatal. b. Mesocortical. c. Mesolimbic. d. Tuberoinfundibular. - ✔✔b.
Mesocortical.
✔✔3. Which pathway mediates prolactin? a. Nigrostriatal. b. Mesocortical. c.
Mesolimbic. d. Tuberoinfundibular. - ✔✔d. Tuberoinfundibular.
✔✔4. The cell bodies of the NE neurons are located in the locus coeruleus and the a.
Medullary reticular formation. b. Raphe nuclei. c. Arcuate nucleus. d. Tuberomammillary
nucleus. - ✔✔a. Medullary reticular formation.
✔✔5. Most of the cell bodies for histamine neurons reside in the a. Medullary reticular
formation. b. Raphe nuclei. c. Arcuate nucleus. d. Tuberomammillary nucleus. -
✔✔Tuberomammillary nucleus
✔✔6. Which statement is not true regarding NO? a. It is quickly degraded. b. It converts
GTP into cGMP. c. It is stored in dense core vesicles. d. It is formed from arginine. -
✔✔c. It is stored in dense core vesicles
✔✔7. All of the following are neuropeptides except a. Cannabinoid peptides. b. Pituitary
peptides. c. Opioid peptides. d. Hypothalamic releasing peptides. - ✔✔a. Cannabinoid
peptides.
✔✔8. The most common neurotransmitter in the brain is a. Serotonin. b. Dopamine. c.
γ-Aminobutyric acid. d. Glutamate. - ✔✔d. Glutamate.
✔✔1. Which equation is correct? a. Antagonist = stimulate. b. Agonist = block. c.
Agonist = transmitter. d. Antagonist = endogenous ligand. - ✔✔Agonist = transmitter
✔✔2. Which is not a glutamate receptor? a. NMDA. b. cAMP. c. AMPA. d. Kainate. -
✔✔b. cAMP
✔✔3. The strength of the GABA inhibitory signal is enhanced by all of the following
except a. Ethanol. b. Phenobarbital. c. Carbamazepine. d. Neurosteroids. - ✔✔c.
Carbamazepine
✔✔4. The AEDs exert their major effects through all of the following except a.
Decreasing glutamate activity. b. Modulation of the voltage-gated sodium channels. c.
Blockade of the voltage-gated calcium channels. d. Increasing GABA activity. -
✔✔Decreasing glutamate activity
, ✔✔5. Which of the following is true? a. Mg2+ is a common secondary messenger. b.
Most monoamine receptors are fast receptors. c. Fast receptors typically lead to gene
expression. d. Autoreceptors give negative feedback to the neuron. - ✔✔d.
Autoreceptors give negative feedback to the neuron.
✔✔6. Gene expression stimulated by a neurotransmitter involves all of the following
except a. Phosphorylation. b. Long-term potentiation. c. Protein kinases. d. G protein-
coupled receptor. - ✔✔b. Long-term potentiation
✔✔7. All of the following about LTP are true except a. Enhanced EPSP. b. Increased
receptors. c. Gene expression. d. Enhanced ligand binding. - ✔✔d. Enhanced ligand
binding
✔✔8. Which describes LTP best? a. It was discovered by accident. b. Neuroscientists
love to pontificate on this topic. c. It is an example of learning. d. All of the above - ✔✔d.
All of the above
✔✔1. Why does the governor of South Carolina have so few protein-coding genes? a.
The governor believes protein-coding genes are another example of too much
government control. b. The governor is closely related to Caenorhabditis elegans. c.
The governor sold off the vast majority of protein-coding genes in an attempt to balance
the State budget. d. Because much of the complexity of the human species is controlled
by other parts of the DNA. - ✔✔Because much of the complexity of the human species
is controlled by other parts of the DNA.
✔✔2. All of the following lead us to believe "junk DNA" is important except a. Non-
protein-coding sections are highly expressed in the brain . b. RNA has more capacity to
control functions in a cell than previously recognized. c. Defects in "junk DNA" have
been identified in autism. d. Some microRNAs have been implicated in schizophrenia. -
✔✔Defects in "junk DNA" have been identified in autism
✔✔3. What has happened to the "chemical imbalance" theories of mental illness in the
genomic era? a. Genome-wide studies fail to implicate genes that are associated with
neurotransmitters or their receptors. b. Genes for the serotonin receptor have been
identified in families with bipolar disorder in multiple linkage studies. c. The dopamine
transporter gene on chromosome 11 is altered in most patients with childhood-onset
schizophrenia. d. A significant number of patients with panic disorder are lacking the
gene for the A section of the GABA receptor. - ✔✔Genome-wide studies fail to implicate
genes that are associated with neurotransmitters or their receptors.
✔✔4. Understanding epigenetics helps us understand a. Why non-protein-coding
sections are so highly expressed in the brain. b. How events in the environment can
alter gene expression. c. The cognitive effects of trisomy 21. d. The increased potential
