Page 1 of 587
ASCP BOC EXAM LATEST 2026-2027 WITH
COMPLETE 500+ QUESTIONS AND CORRECT
VERIFIED SOLUTIONS JUST RELEASED THIS YEAR
Question: 238) Which of the following hormones regulates normal blood calcium levels?
a. thyroxine
b. estriol
c. parathyroid hormone
d. growth hormone - CORRECT ANSWER✔✔c (Parathyroid hormone [PTH] and the hormone
vitamin D play a dominant role in calcium regulation.)
Question: 240) A diagnosis of primary adrenal insufficiency requires demonstration of:
a. decreased urinary 17-keto and 17-hydroxysteroids
b. decreased cortisol production
c. impaired response to ACTH stimulation
d. increased urinary cortisol excretion after metyrapone - CORRECT ANSWER✔✔c (ACTH
stimulation tests, using synthetic ACTH, will differentiate primary from secondary adrenal
insufficiency. Synthetic ACTH will not cause the adrenal gland to respond in primary
insufficiency.)
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Question: 241) The screen for adrenal cortical hyperfunction with the greatest sensitivity and
specificity is:
a. 24 hr. urine free cortisol
b. plasma cortisol
c. urinary 17-hydroxycoricosteroids
d. plasma corticosterone - CORRECT ANSWER✔✔a (The 24-hour urine free cortisol is the most
sensitive and specific screen for hypercortisolism.)
Question: 244) Which of the following sample collections would give an accurate assessment
of potential excess cortisol production?
a. collect a plasma sample as a baseline, and another one 1 hr. after administration of
metyrapone
b. collect a plasma sample at 8 am only
c. collect a 24 hr. urine free cortisol
d. collect a plasma sample at 8 am and at 8 am the next day - CORRECT ANSWER✔✔c (Due to
circadian variation, the 24-hour UFC is an accurate measurement of active forms of cortisol.)
Question: 248) Clinical assays for tumor markers are most important for:
a. screening for the presence of cancer
b. monitoring the course of a known cancer
c. confirming the absence of disease
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d. identifying patients at risk for cancer - CORRECT ANSWER✔✔b (Tumor markers are useful for
monitoring therapy, detecting recurrence and aiding in prognosis of tumors but are not useful
for screening the general population for cancer.)
Question: 249) Detection of which of the following substances is most useful to monitor the
course of a patient with testicular cancer?
a. alpha-fetoprotein
b. carcinoembryonic antigen
c. prolactin
d. testosterone - CORRECT ANSWER✔✔a (Most testicular tumors are germ cell tumors which
are characterized by elevated serum levels of alpha-fetoprotein [AFP]. Measurement of serum
AFP is used in the diagnosis, therapy and follow-up of testicular cancer. The carcinoembryonic
antigen is a marker for colon cancer. The serum levels of testosterone and prolactin are not
increased in testicular cancer.)
Question: 250) Increased concentrations of alpha-fetoprotein in adults are most
characteristically associated with:
a. hepatocellular carcinoma
b. alcoholic cirrhosis
c. chronic active hepatitis
d. multiple myeloma - CORRECT ANSWER✔✔a (Alpha-fetoprotein [AFP] is an oncofetal
glycoprotein marker for hepatocellular carcinoma. Elevated levels of AFP [<200 mg\L] are seen
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in hepatitis and cirrhosis. However, in hepatocellular carcinoma, the levels can be greater than
1,000 mg\L.)
Question: 251) Carcinoembryonic antigen is most likely to be produced in a malignancy
involving the:
a. brain
b. testes
c. bone
d. colon - CORRECT ANSWER✔✔d ( The carcinoembryonic antigen [CEA] is a marker for colon,
gastrointestinal and lung cancer. Elevated serum levels of CEA are primarily seen with colon
cancer. Although the levels may be increased in individuals with benign conditions, the level of
CEA elevation is greater for colon cancer.)
Question: 252) Which of the following is useful in the detection and management of carcinoma
of the prostate?
a. total prostate-specific antigen
b. prostatic acid phosphatase
c. human chorionic gonadotropin
d. alpha-fetoprotein - CORRECT ANSWER✔✔a (tPSA along with DRE is the recommended screen
for prostate cancer in males over 50 years of age.)
4
SUCCESS!
ASCP BOC EXAM LATEST 2026-2027 WITH
COMPLETE 500+ QUESTIONS AND CORRECT
VERIFIED SOLUTIONS JUST RELEASED THIS YEAR
Question: 238) Which of the following hormones regulates normal blood calcium levels?
a. thyroxine
b. estriol
c. parathyroid hormone
d. growth hormone - CORRECT ANSWER✔✔c (Parathyroid hormone [PTH] and the hormone
vitamin D play a dominant role in calcium regulation.)
Question: 240) A diagnosis of primary adrenal insufficiency requires demonstration of:
a. decreased urinary 17-keto and 17-hydroxysteroids
b. decreased cortisol production
c. impaired response to ACTH stimulation
d. increased urinary cortisol excretion after metyrapone - CORRECT ANSWER✔✔c (ACTH
stimulation tests, using synthetic ACTH, will differentiate primary from secondary adrenal
insufficiency. Synthetic ACTH will not cause the adrenal gland to respond in primary
insufficiency.)
1
SUCCESS!
,Page 2 of 587
Question: 241) The screen for adrenal cortical hyperfunction with the greatest sensitivity and
specificity is:
a. 24 hr. urine free cortisol
b. plasma cortisol
c. urinary 17-hydroxycoricosteroids
d. plasma corticosterone - CORRECT ANSWER✔✔a (The 24-hour urine free cortisol is the most
sensitive and specific screen for hypercortisolism.)
Question: 244) Which of the following sample collections would give an accurate assessment
of potential excess cortisol production?
a. collect a plasma sample as a baseline, and another one 1 hr. after administration of
metyrapone
b. collect a plasma sample at 8 am only
c. collect a 24 hr. urine free cortisol
d. collect a plasma sample at 8 am and at 8 am the next day - CORRECT ANSWER✔✔c (Due to
circadian variation, the 24-hour UFC is an accurate measurement of active forms of cortisol.)
Question: 248) Clinical assays for tumor markers are most important for:
a. screening for the presence of cancer
b. monitoring the course of a known cancer
c. confirming the absence of disease
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d. identifying patients at risk for cancer - CORRECT ANSWER✔✔b (Tumor markers are useful for
monitoring therapy, detecting recurrence and aiding in prognosis of tumors but are not useful
for screening the general population for cancer.)
Question: 249) Detection of which of the following substances is most useful to monitor the
course of a patient with testicular cancer?
a. alpha-fetoprotein
b. carcinoembryonic antigen
c. prolactin
d. testosterone - CORRECT ANSWER✔✔a (Most testicular tumors are germ cell tumors which
are characterized by elevated serum levels of alpha-fetoprotein [AFP]. Measurement of serum
AFP is used in the diagnosis, therapy and follow-up of testicular cancer. The carcinoembryonic
antigen is a marker for colon cancer. The serum levels of testosterone and prolactin are not
increased in testicular cancer.)
Question: 250) Increased concentrations of alpha-fetoprotein in adults are most
characteristically associated with:
a. hepatocellular carcinoma
b. alcoholic cirrhosis
c. chronic active hepatitis
d. multiple myeloma - CORRECT ANSWER✔✔a (Alpha-fetoprotein [AFP] is an oncofetal
glycoprotein marker for hepatocellular carcinoma. Elevated levels of AFP [<200 mg\L] are seen
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in hepatitis and cirrhosis. However, in hepatocellular carcinoma, the levels can be greater than
1,000 mg\L.)
Question: 251) Carcinoembryonic antigen is most likely to be produced in a malignancy
involving the:
a. brain
b. testes
c. bone
d. colon - CORRECT ANSWER✔✔d ( The carcinoembryonic antigen [CEA] is a marker for colon,
gastrointestinal and lung cancer. Elevated serum levels of CEA are primarily seen with colon
cancer. Although the levels may be increased in individuals with benign conditions, the level of
CEA elevation is greater for colon cancer.)
Question: 252) Which of the following is useful in the detection and management of carcinoma
of the prostate?
a. total prostate-specific antigen
b. prostatic acid phosphatase
c. human chorionic gonadotropin
d. alpha-fetoprotein - CORRECT ANSWER✔✔a (tPSA along with DRE is the recommended screen
for prostate cancer in males over 50 years of age.)
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