SOLUTIONS GRADED A+
✔✔The healthcare provider prescribes a medication that is renally eliminated for a
patient with acute renal failure. The nurse recognizes that the patient is at risk for which
altered drug response?
a. Increased drug excretion
b. Decreased drug levels in the blood
c. Development of drug toxicity
d. Increased tolerance to the medication - ✔✔c. Development of drug toxicity
✔✔A nursing student is caring for a patient who has been taking morphine sulfate for
pain for 2 weeks. The nursing student shows an understanding of pharmacodynamic
tolerance by describing it to the instructor in what way?
a. "It is a form of tolerance that is a reduction in drug responsiveness brought on by
repeated dosing over a short period."
b. "It affects the minimum effective concentration."
c. "It is a drug response caused by psychologic factors, not by biochemical or
physiological properties."
d. "It is a condition in which the patient requires increased doses of morphine sulfate to
achieve pain relief." - ✔✔d. "It is a condition in which the patient requires increased
doses of morphine sulfate to achieve pain relief."
✔✔The nurse is caring for a group of female patients receiving medication therapy.
Which factor is of greatest concern with regard to drug therapy in these patients?
a. Most drug research has been carried out exclusively in male subjects.
b. Hormonal differences make managing drug therapy more difficult in most women.
c. Overall, women tend to be less compliant with medication therapy.
d. Women tend to be caregivers and may not take time to care for themselves. - ✔✔a.
Most drug research has been carried out exclusively in male subjects.
✔✔The nurse is caring for a patient prescribed abacavir [Ziagen] to treat human
immunodeficiency virus (HIV) infection. To reduce the potential fatal hypersensitivity
reaction, which recommendation is suggested prior to initiating abacavir drug therapy?
a. Administer a test dose
b. Obtain liver function studies
c. Drug skin testing
d. Genetic screening - ✔✔d. Genetic screening
✔✔The nurse understands drug response varies from one individual to another. What
are examples of individual variations? (Select all that apply.)
a. Age
b. Genetic makeup
c. Gender
d. Diet
, e. Failure to take medication as prescribed - ✔✔a, b, c, d, and e
✔✔The nurse is reading a genetic research study. The study discusses how genetic
variants can directly affect the metabolism of clopidogrel [Plavix], reducing the
antiplatelet response. The nurse understands reduced efficacy of clopidogrel can
increase the risk of which cardiovascular event? (Select all that apply.)
a. Stroke
b. Cancer
c. Myocardial infarction
d. Pulmonary embolism
e, Palpitations - ✔✔a and c
✔✔The nurse is caring for a pregnant patient who has chronic asthma. When
administering medications to this patient, which of the options should the nurse do?
a. Give the medications as ordered, because most drugs do not cross the placenta.
b. First assess the creatinine level, because renal blood flow decreases during
pregnancy.
c. Hold the medications and notify the ordering physician, because drugs that are not
known teratogens may not be safe during pregnancy.
d. Advise the patient that taking asthma medications during pregnancy improve fetal
outcomes. - ✔✔d. Advise the patient that taking asthma medications during pregnancy
improve fetal outcomes.
✔✔A teratogenic drug, such as methotrexate, is most likely to cause learning deficits
during which phase of fetal development?
a. Conception through week 2
b. Weeks 3 to 8
c. First trimester
d. Second and third trimesters - ✔✔d. Second and third trimesters
✔✔The nurse is preparing to give a drug that is not classified according to a Pregnancy
Risk Category. What should the nurse do?
a. Administer the medication, because the nurse knows that it was in use before 1983.
b. Notify the healthcare provider before administering the drug, because it should be
considered a teratogen.
c. Hold the medication, because the drug has a proven risk of fetal harm.
d. Return the medication to the pharmacy to be assigned a Pregnancy Risk Category. -
✔✔a. Administer the medication, because the nurse knows that it was in use before
1983.
✔✔The nurse is caring for a patient with epilepsy who is on anticonvulsant therapy and
is also breast-feeding. Which patient teaching instruction should minimize the risk to the
baby?
a. "Give the dose just before breast-feeding."
b. "Avoid drugs that have a long half-life."